Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process. Osteolysis often occurs in the proximity of a prosthesis that causes either an immunological response or changes in the bone's structural load. Osteolysis may also be caused by pathologies like bone tumors, cysts, or chronic inflammation.
While bone resorption is commonly associated with many diseases or joint problems, the term osteolysis generally refers to a problem common to artificial joint replacements such as total hip replacements, total knee replacements and total shoulder replacements. Osteolysis can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw.[citation needed]
There are several biological mechanisms which may lead to osteolysis. In total hip replacement, the generally accepted explanation[1] for osteolysis involves wear particles (worn off the contact surface of the artificial ball and socket joint). As the body attempts to clean up these wear particles (typically consisting of plastic or metal), it triggers an autoimmune reaction which causes resorption of living bone tissue. Osteolysis has been reported to occur as early as 12 months after implantation and is usually progressive. This may require a revision surgery (replacement of the prosthesis).[citation needed]
Although osteolysis itself is clinically asymptomatic, it can lead to implant loosening or bone breakage, which in turn causes serious medical problems.[citation needed]
Distal clavicular osteolysisedit
Distal clavicular osteolysis (DCO) is often associated with problems weightlifters have with their acromioclavicular joints due to high mechanical stresses put on the clavicle as it meets with the acromion. This condition is often referred to as "weight lifter's shoulder".[2]Medical ultrasonography readily depicts resorption of the distal clavicle as irregular cortical erosions, whereas the acromion remains intact.[3] Associated findings may include distended joint capsule, soft tissueswelling, and joint instability.[citation needed]
A common surgery to treat recalcitrant DCO is resection of distal clavicle by removing a few millimetres of bone from the very end of the bone.[2]
^Sanjeev Agarwal (2004). "Osteolysis - basic science, incidence and diagnosis". Current Orthopaedics. 18 (3): 220–231. doi:10.1016/j.cuor.2004.03.002.
^ abSchwarzkopf R, Ishak C, Elman M, Gelber J, Strauss DN, Jazrawi LM (2008). . Bull NYU Hosp Jt Dis. 66 (2): 94–101. PMID 18537776. Archived from the original on March 4, 2016.
^Arend CF. Ultrasound of the Shoulder. Master Medical Books, 2013. Sample chapter available at ShoulderUS.com
External linksedit
December 15, 2023
osteolysis, active, resorption, bone, matrix, osteoclasts, interpreted, reverse, ossification, although, osteoclasts, active, during, natural, formation, healthy, bone, term, osteolysis, specifically, refers, pathological, process, often, occurs, proximity, pr. Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification Although osteoclasts are active during the natural formation of healthy bone the term osteolysis specifically refers to a pathological process Osteolysis often occurs in the proximity of a prosthesis that causes either an immunological response or changes in the bone s structural load Osteolysis may also be caused by pathologies like bone tumors cysts or chronic inflammation OsteolysisSpecialtyOrthopedics Contents 1 Joint replacement 2 Distal clavicular osteolysis 3 See also 4 References 5 External linksJoint replacement editWhile bone resorption is commonly associated with many diseases or joint problems the term osteolysis generally refers to a problem common to artificial joint replacements such as total hip replacements total knee replacements and total shoulder replacements Osteolysis can also be associated with the radiographic changes seen in those with bisphosphonate related osteonecrosis of the jaw citation needed There are several biological mechanisms which may lead to osteolysis In total hip replacement the generally accepted explanation 1 for osteolysis involves wear particles worn off the contact surface of the artificial ball and socket joint As the body attempts to clean up these wear particles typically consisting of plastic or metal it triggers an autoimmune reaction which causes resorption of living bone tissue Osteolysis has been reported to occur as early as 12 months after implantation and is usually progressive This may require a revision surgery replacement of the prosthesis citation needed Although osteolysis itself is clinically asymptomatic it can lead to implant loosening or bone breakage which in turn causes serious medical problems citation needed Distal clavicular osteolysis editDistal clavicular osteolysis DCO is often associated with problems weightlifters have with their acromioclavicular joints due to high mechanical stresses put on the clavicle as it meets with the acromion This condition is often referred to as weight lifter s shoulder 2 Medical ultrasonography readily depicts resorption of the distal clavicle as irregular cortical erosions whereas the acromion remains intact 3 Associated findings may include distended joint capsule soft tissue swelling and joint instability citation needed A common surgery to treat recalcitrant DCO is resection of distal clavicle by removing a few millimetres of bone from the very end of the bone 2 See also editOsteolytic lesion BiomineralizationReferences edit Sanjeev Agarwal 2004 Osteolysis basic science incidence and diagnosis Current Orthopaedics 18 3 220 231 doi 10 1016 j cuor 2004 03 002 a b Schwarzkopf R Ishak C Elman M Gelber J Strauss DN Jazrawi LM 2008 Distal clavicular osteolysis a review of the literature Bull NYU Hosp Jt Dis 66 2 94 101 PMID 18537776 Archived from the original on March 4 2016 Arend CF Ultrasound of the Shoulder Master Medical Books 2013 Sample chapter available at ShoulderUS comExternal links edit Retrieved from https en wikipedia org w index php title Osteolysis amp oldid 1185723597, wikipedia, wiki, book, books, library,
