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Onychomatricoma

January 01, 1970

Onychomatricoma is a cutaneous condition characterized by a distinctive tumor of the nail matrix.[1]

Onychomatricoma
SpecialtyDermatology

Symptoms include thickness of the nail plate, transverse or longitudinal overcurvature, xanthonychia, and numerous splinter hemorrhages.

The diagnosis of onychomatricoma is made based on clinical features, dermoscopy, and ultrasonography, and is confirmed by its histological features.

Onychomatricoma is treated by surgical excision.

Signs and symptoms edit

Thickness of the nail plate, transverse or longitudinal overcurvature, xanthonychia, and numerous splinter hemorrhage are the four main clinical characteristics of onychomatricoma.[2]

Causes edit

According to recent research, onychomatricoma patients may have genetic changes, such as chromosomal deletion.[3]

Diagnosis edit

In addition to the traditional tetrad symptoms, other diagnostic techniques such dermoscopy, ultrasonography, and histological findings are also used to make the diagnosis.[2]

Hemorrhagic striae, white longitudinal grooves that match the nail plate channels, and perforations in the distal region of the nail plate are all visible during dermoscopy.[4]

A radiological examination reveals no evidence of onychomatricoma-related underlying bone involvement.[5]

An ultrasonographic examination reveals poor blood flow, a hypoechogenic region corresponding to the fingerlike projections, and a hypoechoic tumoral lesion affecting the nail matrix.[6]

The diagnosis of onychomatricoma is confirmed by its unique histological characteristics.[2] Onychomatricoma is a fibroepithelial tumour that has two different regions.[7] The proximal zone, which is defined by deep epithelial invaginations occupied by overlaying ungual protrusions, is situated beneath the posterior nail fold. The distal zone, corresponding to the lunula, is made up of epithelial digitations that grow from the matrix epithelium and puncture the nail plate.[2]

Among the differential diagnoses are osteochondroma, longitudinal melanonychia, fibrokeratoma, onychomycosis, periungual fibroma, squamous cell carcinoma, Bowen's disease, and subungual verruca vulgaris.[8]

Treatment edit

Onychomatricoma is treated with surgical excision.[9] To avoid local recurrence, the tumour must be fully removed, including the normal nail matrix close to the lesion.[10]

Epidemiology edit

As of 2016 less than 80 cases of onychomatricoma have been reported.[2] The majority of cases of onychomatricoma are middle-aged women, with a peak incidence occurring in the fifth decade of life.[8][11]

See also edit

References edit

  1. ^ Freedberg, Irwin M.; Eisen, Arthur Z.; Wolff, Klaus; Austen, K. Frank; Goldsmith, Lowell A.; Katz, Stephen I., eds. (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). McGraw-Hill. p. 667. ISBN 978-0-07-138076-8.
  2. ^ a b c d e Joo, Hong Jin; Kim, Mi Ri; Cho, Baik Kee; Yoo, Gyeol; Park, Hyun Jeong (2016). "Onychomatricoma: A Rare Tumor of Nail Matrix". Annals of Dermatology. 28 (2). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 237–241. doi:10.5021/ad.2016.28.2.237. ISSN 1013-9087. PMC 4828389. PMID 27081273.
  3. ^ Cañueto, Javier; Santos-Briz, Ángel; García, Juan Luis; Robledo, Cristina; Unamuno, Pablo (2011). "Onychomatricoma: Genome-wide analyses of a rare nail matrix tumor". Journal of the American Academy of Dermatology. 64 (3). Elsevier BV: 573–578.e1. doi:10.1016/j.jaad.2009.07.051. ISSN 0190-9622. PMID 20691500.
  4. ^ Richert, B.; André, J. (2011). "L'onychomatricome". Annales de Dermatologie et de Vénéréologie (in French). 138 (1). Elsevier BV: 71–74. doi:10.1016/j.annder.2010.10.027. ISSN 0151-9638. PMID 21276470.
  5. ^ Miteva, Mariya (2011-09-01). "Nail Clipping Diagnosis of Onychomatricoma". Archives of Dermatology. 147 (9). American Medical Association (AMA): 1118. doi:10.1001/archdermatol.2011.240. ISSN 0003-987X. PMID 21931060.
  6. ^ Soto, Rosamary; Wortsman, Ximena; Corredoira, Yamile (2009-12-01). "Onychomatricoma: Clinical and Sonographic Findings". Archives of Dermatology. 145 (12). American Medical Association (AMA): 1461–1462. doi:10.1001/archdermatol.2009.312. ISSN 0003-987X. PMID 20026866.
  7. ^ Perrin, Ch.; Goettmann, S.; Baran, R. (1998). "Onychomatricoma: Clinical and histopathologic findings in 12 cases". Journal of the American Academy of Dermatology. 39 (4). Elsevier BV: 560–564. doi:10.1016/s0190-9622(98)70004-0. ISSN 0190-9622. PMID 9777762.
  8. ^ a b Tavares, Glaysson Tassara; Chiacchio, Nilton Gioia Di; Chiacchio, Nilton Di; Souza, Marcos Vilela de (2015). "Onychomatricoma: a tumor unknown to dermatologists". Anais Brasileiros de Dermatologia. 90 (2). FapUNIFESP (SciELO): 265–267. doi:10.1590/abd1806-4841.20153650. ISSN 0365-0596. PMC 4371682. PMID 25831003.
  9. ^ Estrada-Chavez, Guadalupe; Vega-Memije, M. E.; Toussaint-Caire, S.; Rangel, L.; Dominguez-Cherit, J. (2007). "Giant onychomatricoma: report of two cases with rare clinical presentation". International Journal of Dermatology. 46 (6). Wiley: 634–636. doi:10.1111/j.1365-4632.2007.03300.x. ISSN 0011-9059. PMID 17550569.
  10. ^ Gaertner, Erich M.; Gordon, Michael; Reed, Thomas (2009-09-17). "Onychomatricoma: case report of an unusual subungual tumor with literature review". Journal of Cutaneous Pathology. 36 (s1). Wiley: 66–69. doi:10.1111/j.1600-0560.2008.01218.x. ISSN 0303-6987. PMID 19469867.
  11. ^ Di Chiacchio, N.; Tavares, G.T.; Tosti, A.; Di Chiacchio, N.G.; Di Santis, E.; Alvarenga, L.; Stuhr, P.; De Farias, D. (2015-08-27). "Onychomatricoma: epidemiological and clinical findings in a large series of 30 cases". British Journal of Dermatology. 173 (5). Oxford University Press (OUP): 1305–1307. doi:10.1111/bjd.13900. ISSN 0007-0963. PMID 25970230.

Further reading edit

  • Lee, Dong-Youn (2013). "The Relation of Onychomatricoma to Onychodermis in the Nail Unit". Annals of Dermatology. 25 (3). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 394–395. doi:10.5021/ad.2013.25.3.394. ISSN 1013-9087. PMC 3756218. PMID 24003296.
  • Perrin, Christophe; Baran, Robert; Balaguer, Thierry; Chignon-Sicard, Bérangère; Cannata, Giuseppe E; Petrella, Tony; Michiels, Jean-François (2010). "Onychomatricoma: New Clinical and Histological Features. A Review of 19 Tumors". The American Journal of Dermatopathology. 32 (1). Ovid Technologies (Wolters Kluwer Health): 1–8. doi:10.1097/dad.0b013e3181af8516. ISSN 0193-1091. PMID 20098079.

External links edit

  • DermNet
  • VisualDx

January 01, 1970
onychomatricoma, cutaneous, condition, characterized, distinctive, tumor, nail, matrix, specialtydermatology, symptoms, include, thickness, nail, plate, transverse, longitudinal, overcurvature, xanthonychia, numerous, splinter, hemorrhages, diagnosis, onychoma. Onychomatricoma is a cutaneous condition characterized by a distinctive tumor of the nail matrix 1 OnychomatricomaSpecialtyDermatology Symptoms include thickness of the nail plate transverse or longitudinal overcurvature xanthonychia and numerous splinter hemorrhages The diagnosis of onychomatricoma is made based on clinical features dermoscopy and ultrasonography and is confirmed by its histological features Onychomatricoma is treated by surgical excision Contents 1 Signs and symptoms 2 Causes 3 Diagnosis 4 Treatment 5 Epidemiology 6 See also 7 References 8 Further reading 9 External linksSigns and symptoms editThickness of the nail plate transverse or longitudinal overcurvature xanthonychia and numerous splinter hemorrhage are the four main clinical characteristics of onychomatricoma 2 Causes editAccording to recent research onychomatricoma patients may have genetic changes such as chromosomal deletion 3 Diagnosis editIn addition to the traditional tetrad symptoms other diagnostic techniques such dermoscopy ultrasonography and histological findings are also used to make the diagnosis 2 Hemorrhagic striae white longitudinal grooves that match the nail plate channels and perforations in the distal region of the nail plate are all visible during dermoscopy 4 A radiological examination reveals no evidence of onychomatricoma related underlying bone involvement 5 An ultrasonographic examination reveals poor blood flow a hypoechogenic region corresponding to the fingerlike projections and a hypoechoic tumoral lesion affecting the nail matrix 6 The diagnosis of onychomatricoma is confirmed by its unique histological characteristics 2 Onychomatricoma is a fibroepithelial tumour that has two different regions 7 The proximal zone which is defined by deep epithelial invaginations occupied by overlaying ungual protrusions is situated beneath the posterior nail fold The distal zone corresponding to the lunula is made up of epithelial digitations that grow from the matrix epithelium and puncture the nail plate 2 Among the differential diagnoses are osteochondroma longitudinal melanonychia fibrokeratoma onychomycosis periungual fibroma squamous cell carcinoma Bowen s disease and subungual verruca vulgaris 8 Treatment editOnychomatricoma is treated with surgical excision 9 To avoid local recurrence the tumour must be fully removed including the normal nail matrix close to the lesion 10 Epidemiology editAs of 2016 less than 80 cases of onychomatricoma have been reported 2 The majority of cases of onychomatricoma are middle aged women with a peak incidence occurring in the fifth decade of life 8 11 See also editNail anatomy List of cutaneous conditions Nail diseaseReferences edit Freedberg Irwin M Eisen Arthur Z Wolff Klaus Austen K Frank Goldsmith Lowell A Katz Stephen I eds 2003 Fitzpatrick s Dermatology in General Medicine 6th ed McGraw Hill p 667 ISBN 978 0 07 138076 8 a b c d e Joo Hong Jin Kim Mi Ri Cho Baik Kee Yoo Gyeol Park Hyun Jeong 2016 Onychomatricoma A Rare Tumor of Nail Matrix Annals of Dermatology 28 2 Korean Dermatological Association and The Korean Society for Investigative Dermatology 237 241 doi 10 5021 ad 2016 28 2 237 ISSN 1013 9087 PMC 4828389 PMID 27081273 Canueto Javier Santos Briz Angel Garcia Juan Luis Robledo Cristina Unamuno Pablo 2011 Onychomatricoma Genome wide analyses of a rare nail matrix tumor Journal of the American Academy of Dermatology 64 3 Elsevier BV 573 578 e1 doi 10 1016 j jaad 2009 07 051 ISSN 0190 9622 PMID 20691500 Richert B Andre J 2011 L onychomatricome Annales de Dermatologie et de Venereologie in French 138 1 Elsevier BV 71 74 doi 10 1016 j annder 2010 10 027 ISSN 0151 9638 PMID 21276470 Miteva Mariya 2011 09 01 Nail Clipping Diagnosis of Onychomatricoma Archives of Dermatology 147 9 American Medical Association AMA 1118 doi 10 1001 archdermatol 2011 240 ISSN 0003 987X PMID 21931060 Soto Rosamary Wortsman Ximena Corredoira Yamile 2009 12 01 Onychomatricoma Clinical and Sonographic Findings Archives of Dermatology 145 12 American Medical Association AMA 1461 1462 doi 10 1001 archdermatol 2009 312 ISSN 0003 987X PMID 20026866 Perrin Ch Goettmann S Baran R 1998 Onychomatricoma Clinical and histopathologic findings in 12 cases Journal of the American Academy of Dermatology 39 4 Elsevier BV 560 564 doi 10 1016 s0190 9622 98 70004 0 ISSN 0190 9622 PMID 9777762 a b Tavares Glaysson Tassara Chiacchio Nilton Gioia Di Chiacchio Nilton Di Souza Marcos Vilela de 2015 Onychomatricoma a tumor unknown to dermatologists Anais Brasileiros de Dermatologia 90 2 FapUNIFESP SciELO 265 267 doi 10 1590 abd1806 4841 20153650 ISSN 0365 0596 PMC 4371682 PMID 25831003 Estrada Chavez Guadalupe Vega Memije M E Toussaint Caire S Rangel L Dominguez Cherit J 2007 Giant onychomatricoma report of two cases with rare clinical presentation International Journal of Dermatology 46 6 Wiley 634 636 doi 10 1111 j 1365 4632 2007 03300 x ISSN 0011 9059 PMID 17550569 Gaertner Erich M Gordon Michael Reed Thomas 2009 09 17 Onychomatricoma case report of an unusual subungual tumor with literature review Journal of Cutaneous Pathology 36 s1 Wiley 66 69 doi 10 1111 j 1600 0560 2008 01218 x ISSN 0303 6987 PMID 19469867 Di Chiacchio N Tavares G T Tosti A Di Chiacchio N G Di Santis E Alvarenga L Stuhr P De Farias D 2015 08 27 Onychomatricoma epidemiological and clinical findings in a large series of 30 cases British Journal of Dermatology 173 5 Oxford University Press OUP 1305 1307 doi 10 1111 bjd 13900 ISSN 0007 0963 PMID 25970230 Further reading editLee Dong Youn 2013 The Relation of Onychomatricoma to Onychodermis in the Nail Unit Annals of Dermatology 25 3 Korean Dermatological Association and The Korean Society for Investigative Dermatology 394 395 doi 10 5021 ad 2013 25 3 394 ISSN 1013 9087 PMC 3756218 PMID 24003296 Perrin Christophe Baran Robert Balaguer Thierry Chignon Sicard Berangere Cannata Giuseppe E Petrella Tony Michiels Jean Francois 2010 Onychomatricoma New Clinical and Histological Features A Review of 19 Tumors The American Journal of Dermatopathology 32 1 Ovid Technologies Wolters Kluwer Health 1 8 doi 10 1097 dad 0b013e3181af8516 ISSN 0193 1091 PMID 20098079 External links editDermNet VisualDx Retrieved from https en wikipedia org w index php title Onychomatricoma amp oldid 1215115683, wikipedia, wiki, book, books, library,

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