An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.[1][2] The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant.
Oncocytoma of the salivary gland. This lesion presented as a lateral anterior neck mass. At surgery, it was found to be a soft 3.0 × 2.1 × 1.8 cm tumor of the submandibular salivary gland. The photo shows the characteristic dark color of an oncocytoma, a rare type of benign neoplasm, at the left side of the image (the normal lobulated salivary gland tissue is to the right).
The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei. The granules are created by the mitochondria.[citation needed]
SymptomsEdit
Salivary gland oncocytomas are most common in ages 70–80, females, the parotid gland (85–90%), and are firm, slowly growing, painless masses of less than 4 cm. They may be bilateral.[citation needed]
Thyroid oncocytomaEdit
Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Also known as Hürtle cell tumours. Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland. There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a diagnosis of malignancy is the identification of transcapsular or vascular invasion.[citation needed]
SymptomsEdit
Patients with thyroid oncocytomas present with a thyroid nodule, usually with normal thyroid function. If the tumor is big or invasive, there may be other symptoms such as difficulty swallowing or talking.[citation needed]
Gross appearance of the cut surface of a nephrectomy specimen containing a renal oncocytoma. Note the rounded contour, the mahogany colour and the central scar.
^Coburn V, Radfar A, Snook D, Mahalingam M (April 2007). "Cutaneous oncocytoma - a report of three cases and review of the literature". Journal of Cutaneous Pathology. 34 (4): 355–359. doi:10.1111/j.1600-0560.2006.00620.x. PMID 17381809. S2CID 19955625.
^"Atlas of Genetics and Cytogenetics in Oncology and Haematology - Thyroid:oncocytic tumors". Retrieved 2009-02-01.
External linksEdit
October 20, 2023
oncocytoma, oncocytoma, tumor, made, oncocytes, epithelial, cells, characterized, excessive, amount, mitochondria, resulting, abundant, acidophilic, granular, cytoplasm, cells, tumor, that, they, compose, often, benign, sometimes, premalignant, malignant, spec. An oncocytoma is a tumor made up of oncocytes epithelial cells characterized by an excessive amount of mitochondria resulting in an abundant acidophilic granular cytoplasm 1 2 The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant OncocytomaSpecialtyOncology Symptoms4 Contents 1 Presentation 2 Renal oncocytoma 3 Salivary gland oncocytoma 3 1 Symptoms 4 Thyroid oncocytoma 4 1 Symptoms 5 Additional images 6 See also 7 References 8 External linksPresentation EditAn oncocytoma is an epithelial tumor composed of oncocytes large eosinophilic cells having small round benign appearing nuclei with large nucleoli citation needed Oncocytoma can arise in a number of organs citation needed Renal oncocytoma EditMain article Renal oncocytoma Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney It represents 5 to 15 of surgically resected renal neoplasms citation needed Salivary gland oncocytoma Edit nbsp Oncocytoma of the salivary gland This lesion presented as a lateral anterior neck mass At surgery it was found to be a soft 3 0 2 1 1 8 cm tumor of the submandibular salivary gland The photo shows the characteristic dark color of an oncocytoma a rare type of benign neoplasm at the left side of the image the normal lobulated salivary gland tissue is to the right The salivary gland oncocytoma is a well circumscribed benign neoplastic growth also called an oxyphilic adenoma It comprises about 1 of all salivary gland tumors The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes which are granular acidophilic parotid cells with centrally located nuclei The granules are created by the mitochondria citation needed Symptoms Edit Salivary gland oncocytomas are most common in ages 70 80 females the parotid gland 85 90 and are firm slowly growing painless masses of less than 4 cm They may be bilateral citation needed Thyroid oncocytoma EditThyroid oncocytomas can be benign adenomas or malignant carcinomas Also known as Hurtle cell tumours Grossly oncocytic adenomas are encapsulated solid nodules with a characteristic brown cut surface The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a diagnosis of malignancy is the identification of transcapsular or vascular invasion citation needed Symptoms Edit Patients with thyroid oncocytomas present with a thyroid nodule usually with normal thyroid function If the tumor is big or invasive there may be other symptoms such as difficulty swallowing or talking citation needed Additional images Edit nbsp Micrograph of a renal oncocytoma H amp E stain nbsp Micrograph of a renal oncocytoma H amp E stain nbsp Gross appearance of the cut surface of a nephrectomy specimen containing a renal oncocytoma Note the rounded contour the mahogany colour and the central scar See also EditKidney Renal cell carcinoma Hurthle cellReferences Edit Coburn V Radfar A Snook D Mahalingam M April 2007 Cutaneous oncocytoma a report of three cases and review of the literature Journal of Cutaneous Pathology 34 4 355 359 doi 10 1111 j 1600 0560 2006 00620 x PMID 17381809 S2CID 19955625 Atlas of Genetics and Cytogenetics in Oncology and Haematology Thyroid oncocytic tumors Retrieved 2009 02 01 External links Edit Retrieved from https en wikipedia org w index php title Oncocytoma amp oldid 1124182958, wikipedia, wiki, book, books, library,
