omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.[1]
^King GF, Fletcher JI, Tedford HW (2001). "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. doi:10.1074/jbc.M102199200. PMID 11313356.
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omega, atracotoxin, atracotoxin, insect, specific, neurotoxin, produced, blue, mountains, funnel, spider, phylogenetic, specificity, derives, from, ability, antagonise, insect, vertebrate, voltage, gated, calcium, channels, spatially, proximal, amino, acid, re. omega Atracotoxin w atracotoxin is an insect specific neurotoxin produced by the Blue Mountains funnel web spider Its phylogenetic specificity derives from its ability to antagonise insect but not vertebrate voltage gated calcium channels Two spatially proximal amino acid residues Asn 27 and Arg 35 form a contiguous molecular surface that is essential for toxin activity It has been proposed that this surface of the beta hairpin is a key site for interaction of the toxin with insect calcium channels 1 w AtracotoxinIdentifiersSymbolOmega toxinPfamPF06357InterProIPR009415SCOP21hvw SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryPDB1hvw A 4 23 1axh 1 37See also EditAtracotoxinReferences Edit King GF Fletcher JI Tedford HW 2001 Functional significance of the beta hairpin in the insecticidal neurotoxin omega atracotoxin Hv1a J Biol Chem 276 28 26568 26576 doi 10 1074 jbc M102199200 PMID 11313356 This article incorporates text from the public domain Pfam and InterPro IPR009415 This protein related article is a stub You can help Wikipedia by expanding it vte This neurotoxin article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Omega Atracotoxin amp oldid 950946437, wikipedia, wiki, book, books, library,
