Olorofim (F901318) is an experimental antifungal drug being developed for invasive mold infections.[1][2] If approved it would be a first-in-class medication (for the orotomide class). In 2023, the FDA decided not to approve the drug and to request more data about the safety of the drug.[3] Olorofim does not inhibit growth of Candida species.[2]
^Neoh, Chin Fen; Jeong, Wirawan; Kong, David CM; Slavin, Monica A (2023). "The antifungal pipeline for invasive fungal diseases: what does the future hold?". Expert Review of Anti-infective Therapy. 21 (6): 577–594. doi:10.1080/14787210.2023.2203383. PMID 37057677. S2CID 258135111.
^ abWiederhold, Nathan P. (2020). "Review of the Novel Investigational Antifungal Olorofim". Journal of Fungi. 6 (3): 122. doi:10.3390/jof6030122. ISSN 2309-608X. PMC7557671. PMID 32751765.
^"FDA Passes on Olorofim Despite Critical Need for Antifungals". Medscape.
April 13, 2024
olorofim, f901318, experimental, antifungal, drug, being, developed, invasive, mold, infections, approved, would, first, class, medication, orotomide, class, 2023, decided, approve, drug, request, more, data, about, safety, drug, does, inhibit, growth, candida. Olorofim F901318 is an experimental antifungal drug being developed for invasive mold infections 1 2 If approved it would be a first in class medication for the orotomide class In 2023 the FDA decided not to approve the drug and to request more data about the safety of the drug 3 Olorofim does not inhibit growth of Candida species 2 OlorofimClinical dataOther namesF901318Legal statusLegal statusInvestigationalIdentifiersIUPAC name 2 1 5 Dimethyl 3 phenylpyrrol 2 yl N 4 4 5 fluoropyrimidin 2 yl piperazin 1 yl phenyl 2 oxoacetamideCAS Number1928707 56 5PubChem CID91885568UNIIT34SH2H9HIChemical and physical dataFormulaC 28H 27F N 6O 2Molar mass498 562 g mol 1References edit Neoh Chin Fen Jeong Wirawan Kong David CM Slavin Monica A 2023 The antifungal pipeline for invasive fungal diseases what does the future hold Expert Review of Anti infective Therapy 21 6 577 594 doi 10 1080 14787210 2023 2203383 PMID 37057677 S2CID 258135111 a b Wiederhold Nathan P 2020 Review of the Novel Investigational Antifungal Olorofim Journal of Fungi 6 3 122 doi 10 3390 jof6030122 ISSN 2309 608X PMC 7557671 PMID 32751765 FDA Passes on Olorofim Despite Critical Need for Antifungals Medscape Retrieved from https en wikipedia org w index php title Olorofim amp oldid 1195504212, wikipedia, wiki, book, books, library,
