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Solute carrier organic anion transporter family member 1B1

December 15, 2023

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.[3][4] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.[5] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.[6]

SLCO1B1
Identifiers
AliasesSLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDsOMIM: 604843 HomoloGene: 74575 GeneCards: SLCO1B1
Orthologs
SpeciesHumanMouse
Entrez

10599

n/a

Ensembl

ENSG00000134538

n/a

UniProt

Q9Y6L6

n/a

RefSeq (mRNA)

NM_006446

n/a

RefSeq (protein)

NP_006437

n/a

Location (UCSC)Chr 12: 21.13 – 21.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134538 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem. 274 (24): 17159–63. doi:10.1074/jbc.274.24.17159. PMID 10358072.
  4. ^ "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1".
  5. ^ Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M (2013). "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics. 94 (6): 695–701. doi:10.1038/clpt.2013.161. PMC 3831180. PMID 23942138.
  6. ^ Huser V, Cimino JJ (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science. 2013: 81. PMID 24303303.

Further reading edit

  • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG (2000). "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. doi:10.1074/jbc.274.52.37161. PMID 10601278.
  • König J, Cui Y, Nies AT, Keppler D (2000). "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. doi:10.1152/ajpgi.2000.278.1.G156. PMID 10644574. S2CID 7358020.
  • Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. doi:10.4049/jimmunol.164.6.3169. PMID 10706707.
  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
  • Cui Y, König J, Leier I, Buchholz U, Keppler D (2001). "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. doi:10.1074/jbc.M004968200. PMID 11134001.
  • Tirona RG, Leake BF, Merino G, Kim RB (2001). "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. doi:10.1074/jbc.M103792200. PMID 11477075.
  • Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA (2001). "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. doi:10.1074/jbc.M103988200. PMID 11483603.
  • Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747.
  • Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J (2003). "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. doi:10.1074/jbc.M207735200. PMID 12196548.
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. doi:10.1124/jpet.102.043026. PMID 12490595. S2CID 1475068.
  • Wang P, Kim RB, Chowdhury JR, Wolkoff AW (2003). "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. doi:10.1074/jbc.M301100200. PMID 12670950.
  • Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. S2CID 6570648.
  • Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics. 14 (7): 429–40. doi:10.1097/01.fpc.0000114750.08559.32. PMID 15226675.
  • Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS (2005). "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464.
  • Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. doi:10.1016/j.cbi.2004.08.008. PMID 15535988.
  • Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics. 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125. S2CID 24247125.
  • Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, Edeki T, Sahelijo L, Doan T, Allen A, Spear BB, Kim RB (2006). "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. doi:10.1016/j.clpt.2005.11.003. PMID 16513443. S2CID 21496707.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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December 15, 2023
solute, carrier, organic, anion, transporter, family, member, protein, that, humans, encoded, slco1b1, gene, pharmacogenomic, research, indicates, that, genetic, variations, this, gene, associated, with, response, simvastatin, clinical, guidelines, exist, that. Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene 3 4 Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin 5 Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing 6 SLCO1B1IdentifiersAliasesSLCO1B1 HBLRR LST 1 LST1 OATP C OATP1B1 OATP2 OATPC SLC21A6 solute carrier organic anion transporter family member 1B1External IDsOMIM 604843 HomoloGene 74575 GeneCards SLCO1B1Gene location Human Chr Chromosome 12 human 1 Band12p12 1Start21 131 194 bp 1 End21 239 796 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverpancreatic ductal cellgallbladderrenal cortexcervixcanal of the cervixmouthhaematopoietic systemsalivary glandstomachn aMore reference expression dataBioGPSn aGene ontologyMolecular functiontransporter activity sodium independent organic anion transmembrane transporter activity thyroid hormone transmembrane transporter activity bile acid transmembrane transporter activityCellular componentintegral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane membraneBiological procession transport bile acid and bile salt transport organic anion transport thyroid hormone transport sodium independent organic anion transport transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez10599n aEnsemblENSG00000134538n aUniProtQ9Y6L6n aRefSeq mRNA NM 006446n aRefSeq protein NP 006437n aLocation UCSC Chr 12 21 13 21 24 Mbn aPubMed search 2 n aWikidataView Edit HumanSee also editSolute carrier familyReferences edit a b c GRCh38 Ensembl release 89 ENSG00000134538 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Abe T Kakyo M Tokui T Nakagomi R Nishio T Nakai D Nomura H Unno M Suzuki M Naitoh T Matsuno S Yawo H Jul 1999 Identification of a novel gene family encoding human liver specific organic anion transporter LST 1 J Biol Chem 274 24 17159 63 doi 10 1074 jbc 274 24 17159 PMID 10358072 Entrez Gene SLCO1B1 solute carrier organic anion transporter family member 1B1 Carr DF O Meara H Jorgensen AL Campbell J Hobbs M McCann G van Staa T Pirmohamed M 2013 SLCO1B1 Genetic Variant Associated with Statin Induced Myopathy A Proof of Concept Study Using the Clinical Practice Research Datalink Clinical Pharmacology amp Therapeutics 94 6 695 701 doi 10 1038 clpt 2013 161 PMC 3831180 PMID 23942138 Huser V Cimino JJ 2013 Providing pharmacogenomics clinical decision support using whole genome sequencing data as input AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science 2013 81 PMID 24303303 Further reading editHsiang B Zhu Y Wang Z Wu Y Sasseville V Yang WP Kirchgessner TG 2000 A novel human hepatic organic anion transporting polypeptide OATP2 Identification of a liver specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl CoA reductase inhibitor transporters J Biol Chem 274 52 37161 8 doi 10 1074 jbc 274 52 37161 PMID 10601278 Konig J Cui Y Nies AT Keppler D 2000 A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am J Physiol Gastrointest Liver Physiol 278 1 G156 64 doi 10 1152 ajpgi 2000 278 1 G156 PMID 10644574 S2CID 7358020 Rollinger Holzinger I Eibl B Pauly M Griesser U Hentges F Auer B Pall G Schratzberger P Niederwieser D Weiss EH Zwierzina H 2000 LST1 a gene with extensive alternative splicing and immunomodulatory function J Immunol 164 6 3169 76 doi 10 4049 jimmunol 164 6 3169 PMID 10706707 Konig J Cui Y Nies AT Keppler D 2000 Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide J Biol Chem 275 30 23161 8 doi 10 1074 jbc M001448200 PMID 10779507 Tamai I Nezu J Uchino H Sai Y Oku A Shimane M Tsuji A 2000 Molecular identification and characterization of novel members of the human organic anion transporter OATP family Biochem Biophys Res Commun 273 1 251 60 doi 10 1006 bbrc 2000 2922 PMID 10873595 Cui Y Konig J Leier I Buchholz U Keppler D 2001 Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 J Biol Chem 276 13 9626 30 doi 10 1074 jbc M004968200 PMID 11134001 Tirona RG Leake BF Merino G Kim RB 2001 Polymorphisms in OATP C identification of multiple allelic variants associated with altered transport activity among European and African Americans J Biol Chem 276 38 35669 75 doi 10 1074 jbc M103792200 PMID 11477075 Jung D Hagenbuch B Gresh L Pontoglio M Meier PJ Kullak Ublick GA 2001 Characterization of the human OATP C SLC21A6 gene promoter and regulation of liver specific OATP genes by hepatocyte nuclear factor 1 alpha J Biol Chem 276 40 37206 14 doi 10 1074 jbc M103988200 PMID 11483603 Nozawa T Nakajima M Tamai I Noda K Nezu J Sai Y Tsuji A Yokoi T 2002 Genetic polymorphisms of human organic anion transporters OATP C SLC21A6 and OATP B SLC21A9 allele frequencies in the Japanese population and functional analysis J Pharmacol Exp Ther 302 2 804 13 doi 10 1124 jpet 302 2 804 PMID 12130747 Michalski C Cui Y Nies AT Nuessler AK Neuhaus P Zanger UM Klein K Eichelbaum M Keppler D Konig J 2003 A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter J Biol Chem 277 45 43058 63 doi 10 1074 jbc M207735200 PMID 12196548 Tirona RG Leake BF Wolkoff AW Kim RB 2003 Human organic anion transporting polypeptide C SLC21A6 is a major determinant of rifampin mediated pregnane X receptor activation J Pharmacol Exp Ther 304 1 223 8 doi 10 1124 jpet 102 043026 PMID 12490595 S2CID 1475068 Wang P Kim RB Chowdhury JR Wolkoff AW 2003 The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport J Biol Chem 278 23 20695 9 doi 10 1074 jbc M301100200 PMID 12670950 Nishizato Y Ieiri I Suzuki H Kimura M Kawabata K Hirota T Takane H Irie S Kusuhara H Urasaki Y Urae A Higuchi S Otsubo K Sugiyama Y 2003 Polymorphisms of OATP C SLC21A6 and OAT3 SLC22A8 genes consequences for pravastatin pharmacokinetics Clin Pharmacol Ther 73 6 554 65 doi 10 1016 S0009 9236 03 00060 2 PMID 12811365 S2CID 6570648 Niemi M Schaeffeler E Lang T Fromm MF Neuvonen M Kyrklund C Backman JT Kerb R Schwab M Neuvonen PJ Eichelbaum M Kivisto KT 2005 High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide C OATP C SLCO1B1 Pharmacogenetics 14 7 429 40 doi 10 1097 01 fpc 0000114750 08559 32 PMID 15226675 Huang MJ Kua KE Teng HC Tang KS Weng HW Huang CS 2005 Risk factors for severe hyperbilirubinemia in neonates Pediatr Res 56 5 682 9 doi 10 1203 01 PDR 0000141846 37253 AF PMID 15319464 Campbell SD de Morais SM Xu JJ 2005 Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug induced hyperbilirubinemia Chem Biol Interact 150 2 179 87 doi 10 1016 j cbi 2004 08 008 PMID 15535988 Huang CS Huang MJ Lin MS Yang SS Teng HC Tang KS 2005 Genetic factors related to unconjugated hyperbilirubinemia amongst adults Pharmacogenet Genomics 15 1 43 50 doi 10 1097 01213011 200501000 00007 PMID 15864125 S2CID 24247125 Katz DA Carr R Grimm DR Xiong H Holley Shanks R Mueller T Leake B Wang Q Han L Wang PG Edeki T Sahelijo L Doan T Allen A Spear BB Kim RB 2006 Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics Clin Pharmacol Ther 79 3 186 96 doi 10 1016 j clpt 2005 11 003 PMID 16513443 S2CID 21496707 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Solute carrier organic anion transporter family member 1B1 amp oldid 1189320154, wikipedia, wiki, book, books, library,

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