A noxious stimulus is a stimulus strong enough to threaten the body's integrity (i.e. cause damage to tissue). Noxious stimulation induces peripheral afferents responsible for transducing pain (including A-delta and C- nerve fibers, as well as free nerve endings) throughout the nervous system of an organism.
The ability to perceive noxious stimuli is a prerequisite for nociception, which itself is a prerequisite for nociceptive pain.[1] A noxious stimulus has been seen to drive nocifensive behavioral responses, which are responses to noxious or painful stimuli. These include reflexive, escape behaviors, to avoid harm to an organism's body.
Because of rare genetic conditions that inhibit the ability to perceive physical pain, such as congenital insensitivity to pain and anhydrosis (CIPA), noxious stimulation does not invariably lead to tissue damage.[1]
There are some types of tissue damage that are not detected by any sensory receptors, and thus cannot cause pain. Therefore, not all noxious stimuli are adequate stimuli of nociceptors. The adequate stimuli of nociceptors are termed nociceptive stimuli.
Referencesedit
^ abLoeser, John D.; Treede, Rolf D. (2008). "The Kyoto protocol of IASP Basic Pain Terminology". Pain. 137 (3): 473–7. doi:10.1016/j.pain.2008.04.025. PMID 18583048. S2CID 19538321. from the original on 2022-01-21. Retrieved 2022-03-07.
April 10, 2024
noxious, stimulus, noxious, stimulus, stimulus, strong, enough, threaten, body, integrity, cause, damage, tissue, noxious, stimulation, induces, peripheral, afferents, responsible, transducing, pain, including, delta, nerve, fibers, well, free, nerve, endings,. A noxious stimulus is a stimulus strong enough to threaten the body s integrity i e cause damage to tissue Noxious stimulation induces peripheral afferents responsible for transducing pain including A delta and C nerve fibers as well as free nerve endings throughout the nervous system of an organism The ability to perceive noxious stimuli is a prerequisite for nociception which itself is a prerequisite for nociceptive pain 1 A noxious stimulus has been seen to drive nocifensive behavioral responses which are responses to noxious or painful stimuli These include reflexive escape behaviors to avoid harm to an organism s body Because of rare genetic conditions that inhibit the ability to perceive physical pain such as congenital insensitivity to pain and anhydrosis CIPA noxious stimulation does not invariably lead to tissue damage 1 Noxious stimuli can either be mechanical e g pinching or other tissue deformation chemical e g exposure to acid or irritant or thermal e g high or low temperatures There are some types of tissue damage that are not detected by any sensory receptors and thus cannot cause pain Therefore not all noxious stimuli are adequate stimuli of nociceptors The adequate stimuli of nociceptors are termed nociceptive stimuli References edit a b Loeser John D Treede Rolf D 2008 The Kyoto protocol of IASP Basic Pain Terminology Pain 137 3 473 7 doi 10 1016 j pain 2008 04 025 PMID 18583048 S2CID 19538321 Archived from the original on 2022 01 21 Retrieved 2022 03 07 Retrieved from https en wikipedia org w index php title Noxious stimulus amp oldid 1218078397, wikipedia, wiki, book, books, library,
