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Neuropeptide K

Neuropeptide K (also known as neurokinin K[1]), is a protein encoded by the TAC1 gene. It is an elongated derivative of the N-terminus of neurokinin A as the final post-translational processing product of beta-preprotachykinin.[2][3]

Like neurokinin A, neuropeptide K has been localized to sensory neurons and likely plays a role in regulating sensation.[3]

While several mammalian brains are shown to express substance P and neurokinin A, they differ on expression of neurokinin A-derived peptides. In contrast with rat and cow brains, the human brain contains larger amounts of neuropeptide K.[4]

References edit

  1. ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C (August 1993). "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior". Physiol. Behav. 54 (2): 249–58. doi:10.1016/0031-9384(93)90107-Q. PMID 7690487. S2CID 33412235.
  2. ^ Takeda, Y; Krause, JE (Jan 1989). "Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation". Proc Natl Acad Sci U S A. 86 (1): 392–396. Bibcode:1989PNAS...86..392T. doi:10.1073/pnas.86.1.392. PMC 286471. PMID 2463627.
  3. ^ a b Holzer, P. (1988-03-01). "Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides". Neuroscience. 24 (3): 739–768. doi:10.1016/0306-4522(88)90064-4. PMID 3288903. S2CID 35325223.
  4. ^ Bannon, Michael J.; Poosch, Michael S.; Haverstick, Doris M.; Anita, Mandal; Xue, Iris C. -H.; Shibata, Kazuhiko; Dragovic, Ljubisa J. (1992-01-01). "Preprotachykinin gene expression in the human basal ganglia: characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing". Molecular Brain Research. 12 (1–3): 225–231. doi:10.1016/0169-328X(92)90088-S. PMID 1312203.

neuropeptide, also, known, neurokinin, protein, encoded, tac1, gene, elongated, derivative, terminus, neurokinin, final, post, translational, processing, product, beta, preprotachykinin, like, neurokinin, neuropeptide, been, localized, sensory, neurons, likely. Neuropeptide K also known as neurokinin K 1 is a protein encoded by the TAC1 gene It is an elongated derivative of the N terminus of neurokinin A as the final post translational processing product of beta preprotachykinin 2 3 Like neurokinin A neuropeptide K has been localized to sensory neurons and likely plays a role in regulating sensation 3 While several mammalian brains are shown to express substance P and neurokinin A they differ on expression of neurokinin A derived peptides In contrast with rat and cow brains the human brain contains larger amounts of neuropeptide K 4 References edit Dornan WA Vink KL Malen P Short K Struthers W Barrett C August 1993 Site specific effects of intracerebral injections of three neurokinins neurokinin A neurokinin K and neurokinin gamma on the expression of male rat sexual behavior Physiol Behav 54 2 249 58 doi 10 1016 0031 9384 93 90107 Q PMID 7690487 S2CID 33412235 Takeda Y Krause JE Jan 1989 Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P induced salivation Proc Natl Acad Sci U S A 86 1 392 396 Bibcode 1989PNAS 86 392T doi 10 1073 pnas 86 1 392 PMC 286471 PMID 2463627 a b Holzer P 1988 03 01 Local effector functions of capsaicin sensitive sensory nerve endings Involvement of tachykinins calcitonin gene related peptide and other neuropeptides Neuroscience 24 3 739 768 doi 10 1016 0306 4522 88 90064 4 PMID 3288903 S2CID 35325223 Bannon Michael J Poosch Michael S Haverstick Doris M Anita Mandal Xue Iris C H Shibata Kazuhiko Dragovic Ljubisa J 1992 01 01 Preprotachykinin gene expression in the human basal ganglia characterization of mRNAs and pre mRNAs produced by alternate RNA splicing Molecular Brain Research 12 1 3 225 231 doi 10 1016 0169 328X 92 90088 S PMID 1312203 Retrieved from https en wikipedia org w index php title Neuropeptide K amp oldid 1062774631, wikipedia, wiki, book, books, library,

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