NSP2 (NS35), is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.[3]
^Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology. 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243.
^Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology. 70 (2): 985–91. doi:10.1128/JVI.70.2.985-991.1996. PMC189903. PMID 8551639.
^Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology. 80 (2): 333–9. doi:10.1099/0022-1317-80-2-333. PMID 10073692.
nsp2, rotavirus, nsp2, ns35, rotavirus, nonstructural, binding, protein, that, accumulates, cytoplasmic, inclusions, viroplasms, required, genome, replication, nsp2, closely, associated, vivo, with, viral, replicase, structural, protein, nsp5, plays, role, str. NSP2 NS35 is a rotavirus nonstructural RNA binding protein that accumulates in cytoplasmic inclusions viroplasms and is required for genome replication 1 NSP2 is closely associated in vivo with the viral replicase 2 The non structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2 3 NSP2 rotavirus NSP2 octamer human rotavirus PDB 2gu0 IdentifiersSymbolRota NS35PfamPF02509InterProIPR003668CATH2gu0SCOP22r7j SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryProtein folds into two domains References edit Kattoura MD Chen X Patton JT August 1994 The rotavirus RNA binding protein NS35 NSP2 forms 10S multimers and interacts with the viral RNA polymerase Virology 202 2 803 813 doi 10 1006 viro 1994 1402 PMID 8030243 Aponte C Poncet D Cohen J February 1996 Recovery and characterization of a replicase complex in rotavirus infected cells by using a monoclonal antibody against NSP2 Journal of Virology 70 2 985 91 doi 10 1128 JVI 70 2 985 991 1996 PMC 189903 PMID 8551639 Fabbretti E Afrikanova I Vascotto F Burrone OR February 1999 Two non structural rotavirus proteins NSP2 and NSP5 form viroplasm like structures in vivo The Journal of General Virology 80 2 333 9 doi 10 1099 0022 1317 80 2 333 PMID 10073692 nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte nbsp This cell biology article is a stub You can help Wikipedia by expanding it vte nbsp This enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NSP2 rotavirus amp oldid 1136143970, wikipedia, wiki, book, books, library,
