Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene. The NPVF gene, and thus the propeptide, are expressed in neurons in the mediobasal hypothalamus.[1] The propeptide is cleaved to form three other peptides, which are:[2][3]
NPSF and NPVF, originally referred to as the RFamide-related peptides RFRP-1 and RFRP-3, respectively,[4] are the mammalian homologs of the avianneuropeptidegonadotropin-inhibitory hormone (GnIH).[2] The mammalian NPVF and avian GnIH genes, along with their aforementioned peptide products, were discovered concurrently in 2000.[1][2] Similarly to the avian GnIH neuropeptide, NPSF and NPVF have been found to potently inhibit gonadotropin secretion.[5] Moreover, a potent and selective antagonist of the NPFF receptors, RF9, has been reported to possess "very strong" gonadotropin-releasing effects in vivo in male and female mice.[6]
^ abJae Young Seong; Hubert Vaudry (7 November 2014). Neuropeptide GPCRs in neuroendocrinology. Frontiers E-books. pp. 226–. ISBN978-2-88919-267-0.
^ abcHinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M (2000). "New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals". Nat. Cell Biol. 2 (10): 703–8. doi:10.1038/35036326. PMID 11025660. S2CID 2580390.
^Gouardères C, Mazarguil H, Mollereau C, Chartrel N, Leprince J, Vaudry H, Zajac JM (2007). "Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding". Neuropharmacology. 52 (2): 376–86. doi:10.1016/j.neuropharm.2006.07.034. PMID 17011599. S2CID 140207990.
^Murakami M, Matsuzaki T, Iwasa T, Yasui T, Irahara M, Osugi T, Tsutsui K (2008). "Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats". J. Endocrinol. 199 (1): 105–12. doi:10.1677/JOE-08-0197. PMID 18653621.
^Clarke IJ, Qi Y, Puspita Sari I, Smith JT (2009). "Evidence that RF-amide related peptides are inhibitors of reproduction in mammals". Front Neuroendocrinol. 30 (3): 371–8. doi:10.1016/j.yfrne.2009.04.001. PMID 19362107. S2CID 7890470.
^Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M (2010). "Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications". Endocrinology. 151 (4): 1902–13. doi:10.1210/en.2009-1259. PMID 20160130.
Further readingedit
Ubuka, Takayoshi; Son, You Lee; Tsutsui, Kazuyoshi (2016). "Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone". General and Comparative Endocrinology. 227: 27–50. doi:10.1016/j.ygcen.2015.09.009. ISSN 0016-6480. PMID 26409890.
This gene article is a stub. You can help Wikipedia by expanding it.
neuropeptide, precursor, also, known, fmrfamide, related, neuropeptide, rfamide, related, peptide, precursor, propeptide, that, mammals, encoded, npvf, rpfp, gene, npvf, gene, thus, propeptide, expressed, neurons, mediobasal, hypothalamus, propeptide, cleaved,. Neuropeptide VF precursor also known as pro FMRFamide related neuropeptide VF or RFamide related peptide precursor is a propeptide that in mammals is encoded by the NPVF or RPFP gene The NPVF gene and thus the propeptide are expressed in neurons in the mediobasal hypothalamus 1 The propeptide is cleaved to form three other peptides which are 2 3 Neuropeptide SF NPSF RFRP 1 agonist of the NPFF1 and NPFF2 receptors EC50 29 nM and 0 0011 nM respectively RFRP 2 does not bind to either of the NPFF receptors no known biological activity Neuropeptide VF NPVF RFRP 3 agonist of the NPFF1 receptor IC50 0 7 nM Neuropeptide VF precursorIdentifiersSymbolNPVFAlt symbolsRPFPHGNC13782 NPSF and NPVF originally referred to as the RFamide related peptides RFRP 1 and RFRP 3 respectively 4 are the mammalian homologs of the avian neuropeptide gonadotropin inhibitory hormone GnIH 2 The mammalian NPVF and avian GnIH genes along with their aforementioned peptide products were discovered concurrently in 2000 1 2 Similarly to the avian GnIH neuropeptide NPSF and NPVF have been found to potently inhibit gonadotropin secretion 5 Moreover a potent and selective antagonist of the NPFF receptors RF9 has been reported to possess very strong gonadotropin releasing effects in vivo in male and female mice 6 See also editNeuropeptide FF FMRFamide Gonadotropin releasing hormone Gonadotropin inhibitory hormone Gonadotropin release inhibitor KisspeptinReferences edit a b Jae Young Seong Hubert Vaudry 7 November 2014 Neuropeptide GPCRs in neuroendocrinology Frontiers E books pp 226 ISBN 978 2 88919 267 0 a b c Hinuma S Shintani Y Fukusumi S Iijima N Matsumoto Y Hosoya M Fujii R Watanabe T Kikuchi K Terao Y Yano T Yamamoto T Kawamata Y Habata Y Asada M Kitada C Kurokawa T Onda H Nishimura O Tanaka M Ibata Y Fujino M 2000 New neuropeptides containing carboxy terminal RFamide and their receptor in mammals Nat Cell Biol 2 10 703 8 doi 10 1038 35036326 PMID 11025660 S2CID 2580390 Gouarderes C Mazarguil H Mollereau C Chartrel N Leprince J Vaudry H Zajac JM 2007 Functional differences between NPFF1 and NPFF2 receptor coupling high intrinsic activities of RFamide related peptides on stimulation of 35S GTPgammaS binding Neuropharmacology 52 2 376 86 doi 10 1016 j neuropharm 2006 07 034 PMID 17011599 S2CID 140207990 Murakami M Matsuzaki T Iwasa T Yasui T Irahara M Osugi T Tsutsui K 2008 Hypophysiotropic role of RFamide related peptide 3 in the inhibition of LH secretion in female rats J Endocrinol 199 1 105 12 doi 10 1677 JOE 08 0197 PMID 18653621 Clarke IJ Qi Y Puspita Sari I Smith JT 2009 Evidence that RF amide related peptides are inhibitors of reproduction in mammals Front Neuroendocrinol 30 3 371 8 doi 10 1016 j yfrne 2009 04 001 PMID 19362107 S2CID 7890470 Pineda R Garcia Galiano D Sanchez Garrido MA Romero M Ruiz Pino F Aguilar E Dijcks FA Blomenrohr M Pinilla L van Noort PI Tena Sempere M 2010 Characterization of the potent gonadotropin releasing activity of RF9 a selective antagonist of RF amide related peptides and neuropeptide FF receptors physiological and pharmacological implications Endocrinology 151 4 1902 13 doi 10 1210 en 2009 1259 PMID 20160130 Further reading editUbuka Takayoshi Son You Lee Tsutsui Kazuyoshi 2016 Molecular cellular morphological physiological and behavioral aspects of gonadotropin inhibitory hormone General and Comparative Endocrinology 227 27 50 doi 10 1016 j ygcen 2015 09 009 ISSN 0016 6480 PMID 26409890 nbsp This gene article is a stub You can help Wikipedia by expanding it vte nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Neuropeptide VF precursor amp oldid 1073190223, wikipedia, wiki, book, books, library,
