Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2gene.[3][4] NCR2 has also been designated as CD336 (cluster of differentiation 336), NKp44, NKP44; NK-p44, LY95, and dJ149M18.1.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000096264 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R (Jun 1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J Exp Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC2192947. PMID 10049942.
Hershkovitz O, Jivov S, Bloushtain N, et al. (2007). "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44". Biochemistry. 46 (25): 7426–36. doi:10.1021/bi7000455. PMID 17536787.
Forte P, Lilienfeld BG, Baumann BC, Seebach JD (2005). "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D". J. Immunol. 175 (8): 5463–70. doi:10.4049/jimmunol.175.8.5463. PMID 16210654.
Fuchs A, Cella M, Kondo T, Colonna M (2005). "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44". Blood. 106 (6): 2076–82. doi:10.1182/blood-2004-12-4802. PMID 15941912.
Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL (2004). "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence". J. Immunol. 172 (2): 899–906. doi:10.4049/jimmunol.172.2.899. PMID 14707061.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Cantoni C, Ponassi M, Biassoni R, et al. (2004). "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity". Structure. 11 (6): 725–34. doi:10.1016/S0969-2126(03)00095-9. PMID 12791260.
Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956. S2CID 27147251.
Cantoni C, Ponassi M, Biassoni R, et al. (2003). "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44". Acta Crystallogr. D. 58 (Pt 10 Pt 2): 1843–5. doi:10.1107/S0907444902012325. PMID 12351833.
ncr2, natural, cytotoxicity, triggering, receptor, protein, that, humans, encoded, gene, also, been, designated, cd336, cluster, differentiation, nkp44, nkp44, ly95, dj149m18, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1hkfidentifiers. Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene 3 4 NCR2 has also been designated as CD336 cluster of differentiation 336 NKp44 NKP44 NK p44 LY95 and dJ149M18 1 5 NCR2Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1HKFIdentifiersAliasesNCR2 CD336 LY95 NK p44 NKP44 dJ149M18 1 natural cytotoxicity triggering receptor 2External IDsOMIM 604531 HomoloGene 130365 GeneCards NCR2Gene location Human Chr Chromosome 6 human 1 Band6p21 1Start41 335 608 bp 1 End41 350 889 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed intibialis anterior muscledeltoid musclesecondary oocyteamniotic fluidcardiasynovial jointhuman penislower lobe of lungjejunal mucosaduodenumn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransmembrane signaling receptor activity protein binding signaling receptor activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane cell surfaceBiological processcellular defense response innate immune response signal transduction regulation of immune response regulation of innate immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9436n aEnsemblENSG00000096264n aUniProtO95944n aRefSeq mRNA NM 004828NM 001199509NM 001199510n aRefSeq protein NP 001186438NP 001186439NP 004819n aLocation UCSC Chr 6 41 34 41 35 Mbn aPubMed search 2 n aWikidataView Edit HumanReferences edit a b c GRCh38 Ensembl release 89 ENSG00000096264 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cantoni C Bottino C Vitale M Pessino A Augugliaro R Malaspina A Parolini S Moretta L Moretta A Biassoni R Jun 1999 NKp44 a triggering receptor involved in tumor cell lysis by activated human natural killer cells is a novel member of the immunoglobulin superfamily J Exp Med 189 5 787 96 doi 10 1084 jem 189 5 787 PMC 2192947 PMID 10049942 Entrez Gene NCR2 natural cytotoxicity triggering receptor 2 NCR2 natural cytotoxicity triggering receptor 2 Homo sapiens human Gene NCBI Further reading editHershkovitz O Jivov S Bloushtain N et al 2007 Characterization of the recognition of tumor cells by the natural cytotoxicity receptor NKp44 Biochemistry 46 25 7426 36 doi 10 1021 bi7000455 PMID 17536787 Forte P Lilienfeld BG Baumann BC Seebach JD 2005 Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D J Immunol 175 8 5463 70 doi 10 4049 jimmunol 175 8 5463 PMID 16210654 Fuchs A Cella M Kondo T Colonna M 2005 Paradoxic inhibition of human natural interferon producing cells by the activating receptor NKp44 Blood 106 6 2076 82 doi 10 1182 blood 2004 12 4802 PMID 15941912 Poggi A Massaro AM Negrini S et al 2005 Tumor induced apoptosis of human IL 2 activated NK cells role of natural cytotoxicity receptors J Immunol 174 5 2653 60 doi 10 4049 jimmunol 174 5 2653 PMID 15728472 Nowbakht P Ionescu MC Rohner A et al 2005 Ligands for natural killer cell activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias Blood 105 9 3615 22 doi 10 1182 blood 2004 07 2585 PMID 15657183 Campbell KS Yusa S Kikuchi Maki A Catina TL 2004 NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence J Immunol 172 2 899 906 doi 10 4049 jimmunol 172 2 899 PMID 14707061 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Cantoni C Ponassi M Biassoni R et al 2004 The three dimensional structure of the human NK cell receptor NKp44 a triggering partner in natural cytotoxicity Structure 11 6 725 34 doi 10 1016 S0969 2126 03 00095 9 PMID 12791260 Augugliaro R Parolini S Castriconi R et al 2003 Selective cross talk among natural cytotoxicity receptors in human natural killer cells Eur J Immunol 33 5 1235 41 doi 10 1002 eji 200323896 PMID 12731048 S2CID 10724743 Allcock RJ Barrow AD Forbes S et al 2003 The human TREM gene cluster at 6p21 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44 Eur J Immunol 33 2 567 77 doi 10 1002 immu 200310033 PMID 12645956 S2CID 27147251 Cantoni C Ponassi M Biassoni R et al 2003 Crystallization and preliminary crystallographic characterization of the extracellular Ig like domain of human natural killer cell activating receptor NKp44 Acta Crystallogr D 58 Pt 10 Pt 2 1843 5 doi 10 1107 S0907444902012325 PMID 12351833 External links editNCR2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH PDBe KB provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 2 NCR2 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte 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