N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name 'N-acetylphosphatidylethanolamine phosphatidohydrolase.^[1][2] It catalyses the following chemical reaction

N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
Identifiers
EC no.	3.1.4.54
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N-acylphosphatidylethanolamine + H₂O ${\displaystyle \rightleftharpoons }$ N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate

This enzyme is involved in the biosynthesis of anandamide.

See also

• Endocannabinoid System
• N-acyl phosphatidylethanolamine

References

1. Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (February 2004). "Molecular characterization of a phospholipase D generating anandamide and its congeners". The Journal of Biological Chemistry. 279 (7): 5298–305. doi:10.1074/jbc.M306642200. PMID 14634025.
2. Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N (May 2006). "Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family". The Journal of Biological Chemistry. 281 (18): 12325–35. doi:10.1074/jbc.M512359200. PMID 16527816.

• Magotti, Paola; Bauer, Inga; Igarashi, Miki; Babagoli, Masih; Marotta, Roberto; Piomelli, Daniele; Garau, Gianpiero (March 2015). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure. 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMC 4351732. PMID 25684574.

External links

• N-acetylphosphatidylethanolamine-hydrolysing+phospholipase+D at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD ((C7orf18, FMP30, NAPE-PLD)) Human Protein Atlas