N-acetylneuraminylgalactosylglucosylceramide b-1,4-N-acetylgalactosaminyltransferase

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, is an enzyme^[1][2][3] that catalyses the following chemical reaction:

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase
Identifiers
EC no.	2.4.1.165
CAS no.	109136-50-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

UDP-N-acetyl-D-galactosamine + N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide ${\displaystyle \rightleftharpoons }$ UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

This enzyme requires Mn²⁺.

Nomenclature

This enzyme is also known as uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase) with systematic name UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase.

References

1. Chien JL, Williams T, Basu S (March 1973). "Biosynthesis of a globoside-type glycosphingolipid by a -N-acetylgalactosaminyltransferase from embryonic chicken brain". The Journal of Biological Chemistry. 248 (5): 1778–85. PMID 4632917.
2. Piller F, Blanchard D, Huet M, Cartron JP (June 1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney". Carbohydrate Research. 149 (1): 171–84. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
3. Takeya A, Hosomi O, Kogure T (January 1987). "Identification and characterization of UDP-GalNAc: NeuAc alpha 2-3Gal beta 1-4Glc(NAc) beta 1-4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human blood plasma". Journal of Biochemistry. 101 (1): 251–9. PMID 3106337.

External links

• N-acetylneuraminylgalactosylglucosylceramide+beta-1,4-N-acetylgalactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)