N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.244, beta1,4-N-acetylgalactosaminyltransferase III, beta4GalNAc-T3, beta1,4-N-acetylgalactosaminyltransferase IV, beta4GalNAc-T4, UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic nameUDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction
UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc).
Referencesedit
^Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H (November 2003). "Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc". The Journal of Biological Chemistry. 278 (48): 47534–44. doi:10.1074/jbc.m308857200. PMID 12966086.
^Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H (March 2004). "Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine". FEBS Letters. 562 (1–3): 134–40. doi:10.1016/s0014-5793(04)00219-4. PMID 15044014.
External linksedit
N-acetyl-beta-glucosaminyl-glycoprotein+4-beta-N-acetylgalactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
acetyl, beta, glucosaminyl, glycoprotein, beta, acetylgalactosaminyltransferase, beta1, acetylgalactosaminyltransferase, beta4galnac, beta1, acetylgalactosaminyltransferase, beta4galnac, acetyl, galactosamine, acetyl, glucosaminyl, group, beta, acetylgalactosa. N acetyl beta glucosaminyl glycoprotein 4 beta N acetylgalactosaminyltransferase EC 2 4 1 244 beta1 4 N acetylgalactosaminyltransferase III beta4GalNAc T3 beta1 4 N acetylgalactosaminyltransferase IV beta4GalNAc T4 UDP N acetyl D galactosamine N acetyl D glucosaminyl group beta 1 4 N acetylgalactosaminyltransferase is an enzyme with systematic name UDP N acetyl D galactosamine N acetyl beta D glucosaminyl group 4 beta N acetylgalactosaminyltransferase 1 2 This enzyme catalyses the following chemical reactionN acetyl beta glucosaminyl glycoprotein 4 beta N acetylgalactosaminyltransferaseIdentifiersEC no 2 4 1 244DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins UDP N acetyl D galactosamine N acetyl beta D glucosaminyl group displaystyle rightleftharpoons UDP N acetyl beta D galactosaminyl 1 gt 4 N acetyl beta D glucosaminyl groupThe enzyme from human can transfer N acetyl D galactosamine GalNAc to N glycan and O glycan substrates that have N acetyl D glucosamine GlcNAc References edit Sato T Gotoh M Kiyohara K Kameyama A Kubota T Kikuchi N Ishizuka Y Iwasaki H Togayachi A Kudo T Ohkura T Nakanishi H Narimatsu H November 2003 Molecular cloning and characterization of a novel human beta 1 4 N acetylgalactosaminyltransferase beta 4GalNAc T3 responsible for the synthesis of N N diacetyllactosediamine galNAc beta 1 4GlcNAc The Journal of Biological Chemistry 278 48 47534 44 doi 10 1074 jbc m308857200 PMID 12966086 Gotoh M Sato T Kiyohara K Kameyama A Kikuchi N Kwon YD Ishizuka Y Iwai T Nakanishi H Narimatsu H March 2004 Molecular cloning and characterization of beta1 4 N acetylgalactosaminyltransferases IV synthesizing N N diacetyllactosediamine FEBS Letters 562 1 3 134 40 doi 10 1016 s0014 5793 04 00219 4 PMID 15044014 External links editN acetyl beta glucosaminyl glycoprotein 4 beta N acetylgalactosaminyltransferase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title N acetyl beta glucosaminyl glycoprotein 4 beta N acetylgalactosaminyltransferase amp oldid 1198289974, wikipedia, wiki, book, books, library,
