For reasons of reproducibility, genetically characterized, stable strains like C57BL/6 were chosen to produce high-resolution images and databases.[1] Well known online resources include:
Despite superficial differences, especially in size and weight, the mouse brain and its function can serve as a powerful animal model for study of human braindiseases or mental disorders (see e.g. Reeler, Chakragati mouse). This is because the genes responsible for building and operating both mouse and human brain are 90% identical.[4] Transgenic mouse lines also allow neuroscientists to specifically target the labeling of certain cell types to probe the neural basis of fundamental processes.[5][6]
The cerebral cortex of a mouse has around 8–14 million neurons while in those humans there are more than 10–15 billion.[7][8] The olfactory bulb volume takes about 2% of the mouse brain by volume in contrast to about 0.01% of the human brain.[9][10]
A biophysically realistic model of the mouse primary motor cortex microcircuit representing a cylindrical volume of 300 μm diameter: 3D visualization, connectivity, dimensions, and neuronal densities, classes, and morphologies[11]
^MacKenzie-Graham, Allan; Jones, Eagle S.; Shattuck, David W.; Dinov, Ivo D.; Bota, Mihail; Toga, Arthur W. (2003). "The Informatics of a C57BL/6J Mouse Brain Atlas". Neuroinformatics. Springer Nature. 1 (4): 397–410. doi:10.1385/ni:1:4:397. ISSN 1539-2791. PMID 15043223. S2CID 81057.
^"ISH Data :: Allen Brain Atlas: Mouse Brain". ISH Data. Retrieved 2019-02-07.
^"Search the library". The Mouse Brain Library. 2003-06-05. Retrieved 2019-02-07.
^Park, Alice (19 January 2007). "The Brain: What the Mouse Brain Tells Us". Time.
^Gordon, J. W.; Scangos, G. A.; Plotkin, D. J.; Barbosa, J. A.; Ruddle, F. H. (1980-12-01). "Genetic transformation of mouse embryos by microinjection of purified DNA". Proceedings of the National Academy of Sciences. 77 (12): 7380–7384. Bibcode:1980PNAS...77.7380G. doi:10.1073/pnas.77.12.7380. ISSN 0027-8424. PMC350507. PMID 6261253.
^Haruyama, Naoto; Cho, Andrew; Kulkarni, Ashok B. (2009). "Overview: Engineering Transgenic Constructs and Mice". Current Protocols in Cell Biology. 42 (1): 19.10.1–19.10.9. doi:10.1002/0471143030.cb1910s42. ISSN 1934-2616. PMC2743315. PMID 19283728.
^"Brain size and intelligence- why a human is smarter than a mouse". DNALC Blogs «. 2012-11-13. Retrieved 2019-02-07.
^Herculano-Houzel, Suzana; Catania, Kenneth; Manger, Paul R.; Kaas, Jon H. (2015). "Mammalian Brains Are Made of These: A Dataset of the Numbers and Densities of Neuronal and Nonneuronal Cells in the Brain of Glires, Primates, Scandentia, Eulipotyphlans, Afrotherians and Artiodactyls, and Their Relationship with Body Mass". Brain, Behavior and Evolution. S. Karger AG. 86 (3–4): 145–163. doi:10.1159/000437413. ISSN 0006-8977. PMID 26418466.
^McGann, John P. (2017-05-11). "Poor human olfaction is a 19th-century myth". Science. American Association for the Advancement of Science (AAAS). 356 (6338): eaam7263. doi:10.1126/science.aam7263. ISSN 0036-8075. PMC5512720. PMID 28495701.
^"Brain Facts and Figures". faculty.washington.edu. Retrieved 2019-02-07.
^Dura-Bernal, Salvador; Neymotin, Samuel A.; Suter, Benjamin A.; Dacre, Joshua; Moreira, Joao V.S.; Urdapilleta, Eugenio; Schiemann, Julia; Duguid, Ian; Shepherd, Gordon M.G.; Lytton, William W. (June 2023). "Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics". Cell Reports. 42 (6): 112574. doi:10.1016/j.celrep.2023.112574. Retrieved 21 June 2023.
December 15, 2023
mouse, brain, article, lead, section, need, rewritten, please, help, improve, lead, read, lead, layout, guide, april, 2019, learn, when, remove, this, template, message, mouse, brain, refers, brain, musculus, various, brain, atlases, exist, lateral, viewfor, r. The article s lead section may need to be rewritten Please help improve the lead and read the lead layout guide April 2019 Learn how and when to remove this template message The mouse brain refers to the brain of Mus musculus Various brain atlases exist Mouse brain lateral viewFor reasons of reproducibility genetically characterized stable strains like C57BL 6 were chosen to produce high resolution images and databases 1 Well known online resources include Allen Brain Atlas 2 Mouse Brain Library 3 High resolution mouse brain atlas BrainMaps High Resolution Brain Maps and Brain Atlases of Mus musculusDespite superficial differences especially in size and weight the mouse brain and its function can serve as a powerful animal model for study of human brain diseases or mental disorders see e g Reeler Chakragati mouse This is because the genes responsible for building and operating both mouse and human brain are 90 identical 4 Transgenic mouse lines also allow neuroscientists to specifically target the labeling of certain cell types to probe the neural basis of fundamental processes 5 6 Contents 1 Anatomy 2 Development 3 See also 4 ReferencesAnatomy editThe cerebral cortex of a mouse has around 8 14 million neurons while in those humans there are more than 10 15 billion 7 8 The olfactory bulb volume takes about 2 of the mouse brain by volume in contrast to about 0 01 of the human brain 9 10 nbsp Mouse brain dorsal view nbsp Mouse brain lateral view nbsp Mouse brain slices nbsp Mouse cingulate cortex neurons nbsp A biophysically realistic model of the mouse primary motor cortex microcircuit representing a cylindrical volume of 300 mm diameter 3D visualization connectivity dimensions and neuronal densities classes and morphologies 11 Development editMouse brain development timelineSee also editList of animals by number of neuronsReferences edit MacKenzie Graham Allan Jones Eagle S Shattuck David W Dinov Ivo D Bota Mihail Toga Arthur W 2003 The Informatics of a C57BL 6J Mouse Brain Atlas Neuroinformatics Springer Nature 1 4 397 410 doi 10 1385 ni 1 4 397 ISSN 1539 2791 PMID 15043223 S2CID 81057 ISH Data Allen Brain Atlas Mouse Brain ISH Data Retrieved 2019 02 07 Search the library The Mouse Brain Library 2003 06 05 Retrieved 2019 02 07 Park Alice 19 January 2007 The Brain What the Mouse Brain Tells Us Time Gordon J W Scangos G A Plotkin D J Barbosa J A Ruddle F H 1980 12 01 Genetic transformation of mouse embryos by microinjection of purified DNA Proceedings of the National Academy of Sciences 77 12 7380 7384 Bibcode 1980PNAS 77 7380G doi 10 1073 pnas 77 12 7380 ISSN 0027 8424 PMC 350507 PMID 6261253 Haruyama Naoto Cho Andrew Kulkarni Ashok B 2009 Overview Engineering Transgenic Constructs and Mice Current Protocols in Cell Biology 42 1 19 10 1 19 10 9 doi 10 1002 0471143030 cb1910s42 ISSN 1934 2616 PMC 2743315 PMID 19283728 Brain size and intelligence why a human is smarter than a mouse DNALC Blogs 2012 11 13 Retrieved 2019 02 07 Herculano Houzel Suzana Catania Kenneth Manger Paul R Kaas Jon H 2015 Mammalian Brains Are Made of These A Dataset of the Numbers and Densities of Neuronal and Nonneuronal Cells in the Brain of Glires Primates Scandentia Eulipotyphlans Afrotherians and Artiodactyls and Their Relationship with Body Mass Brain Behavior and Evolution S Karger AG 86 3 4 145 163 doi 10 1159 000437413 ISSN 0006 8977 PMID 26418466 McGann John P 2017 05 11 Poor human olfaction is a 19th century myth Science American Association for the Advancement of Science AAAS 356 6338 eaam7263 doi 10 1126 science aam7263 ISSN 0036 8075 PMC 5512720 PMID 28495701 Brain Facts and Figures faculty washington edu Retrieved 2019 02 07 Dura Bernal Salvador Neymotin Samuel A Suter Benjamin A Dacre Joshua Moreira Joao V S Urdapilleta Eugenio Schiemann Julia Duguid Ian Shepherd Gordon M G Lytton William W June 2023 Multiscale model of primary motor cortex circuits predicts in vivo cell type specific behavioral state dependent dynamics Cell Reports 42 6 112574 doi 10 1016 j celrep 2023 112574 Retrieved 21 June 2023 Retrieved from https en wikipedia org w index php title Mouse brain amp oldid 1161270327, wikipedia, wiki, book, books, library,
