Monoamniotic twins are identical or semi-identical twins that share the same amniotic sac within their mother's uterus.[1] Monoamniotic twins are always monochorionic and are usually termed Monoamniotic-Monochorionic ("MoMo" or "Mono Mono") twins.[1][2] They share the placenta, but have two separate umbilical cords. Monoamniotic twins develop when an embryo does not split until after formation of the amniotic sac,[1] at about 9–13 days after fertilization.[3] Monoamniotic triplets or other monoamniotic multiples[4] are possible, but extremely rare.[1] Other obscure possibilities include multiples sets where monoamniotic twins are part of a larger gestation such as triplets, quadruplets, or more.
Various types of chorionicity and amniosity (how the baby's sac looks) in monozygotic (one egg/identical) twins as a result of when the blastocyst or embryo splits.
Monoamniotic twins are rare, with an occurrence of 1 in 35,000 to 1 in 60,000 pregnancies.[1][5]
Complicationsedit
The survival rate for monoamniotic twins has been shown to be as high as 81% [6] to 95% [7] in 2009 with aggressive fetal monitoring, although previously reported as being between 50%[1] and 60%.[4] Causes of mortality and morbidity include:
Cord entanglement: The close proximity and absence of amniotic membrane separating the two umbilical cords makes it particularly easy for the twins to become entangled in each other's cords, hindering fetal movement and development.[4] Additionally, entanglement may cause one twin to become stuck in the birth canal during labor and expulsion.[1] Cord entanglement happens to some degree in almost every monoamniotic pregnancy.[1]
Cord compression: One twin may compress the other's umbilical cord, potentially stopping the flow of nutrients and blood and resulting in fetal death.[1][4]
Twin-to-twin transfusion syndrome (TTTS): One twin receives the majority of the nourishment, causing the other twin to become undernourished. TTTS is much more difficult to diagnose in monoamniotic twins than diamniotic ones, since the standard method otherwise is to compare the fluid in the sacs. Rather, TTTS diagnosis in monoamniotic twins relies on comparing the physical development of the twins.[1]
Diagnosisedit
Abdominal ultrasonography of monoamniotic twins at a gestational age of 15 weeks. There is no sign of any membrane between the fetuses. A coronal plane is shown of the twin at left, and a sagittal plane of parts of the upper thorax and head is shown of the twin at right.
Ultrasound is the only way to detect monoamniotic-monochorionic twins before birth.[4] It can show the lack of a membrane between the twins after a couple of weeks' gestation, when the membrane would be visible if present.[4]
Further ultrasounds with high resolution doppler imaging and non-stress tests help to assess the situation and identify potential cord problems.[4]
There is a correlation between having a single yolk sac and having a single amniotic sac.[1] However, it is difficult to detect the number of yolk sacs, because the yolk sac disappears during embryogenesis.[1]
Cord entanglement and compression generally progress slowly, allowing parents and medical caregivers to make decisions carefully.[4]
Treatmentedit
Only a few treatments can give any improvements.
Sulindac has been used experimentally in some monoamniotic twins, lowering the amount of amniotic fluid and thereby inhibiting fetal movement. This is believed to lower the risk of cord entanglement and compression. However, the potential side effects of the drug have been insufficiently investigated.[1][4]
Regular and aggressive fetal monitoring is recommended for cases of monoamniotic twins to look for cord entanglement beginning after viability. Many women enter inpatient care, with continuous monitoring,[1] preferably in the care of a perinatologist, an obstetrician that specialises in high-risk pregnancies.[4] However RCOG's guidelines[8] cite Dias et al.[9] in observing that cord entanglement is nearly always found in monoamniotic pregnancies and it is not clearly associated with poor outcomes, with most fetal deaths instead arising from twin reversed arterial perfusion or fetal anomaly.
The clinical guidelines of ACOG and RCOG both recommend premature delivery by cesarean section between 32 and 34 weeks.[10][8] A retrospective study in 2016 argued that there is evidence vaginal delivery can be equally safe and reduce complications for some monoamniotic twins[11] but this finding has not been incorporated into clinical guidelines.
^Shulman LS, van Vugt JM (2006). Prenatal medicine. Washington, DC: Taylor & Francis. p. 447. ISBN0-8247-2844-0.
^ abcdefghijMoMo Twins; Monochorionic Monoamniotic Twins By Pamela Prindle Fierro, About.com. Retrieved on July 9, 2009
^"How rare are MoMo twins". MoMoTwins.org. Retrieved Feb 14, 2022.
^Hack KE, Derks JB, Schaap AH, Lopriore E, Elias SG, Arabin B, Eggink AJ, Sollie KM, Mol BW, Duvekot HJ, Willekes C, Go AT, Koopman-Esseboom C, Vandenbussche FP, Visser GH (February 2009). "Perinatal outcome of monoamniotic twin pregnancies". Obstetrics and Gynecology. 113 (2 Pt 1): 353–60. doi:10.1097/AOG.0b013e318195bd57. PMID 19155906. S2CID 10186845.
^Baxi LV, Walsh CA (June 2010). "Monoamniotic twins in contemporary practice: a single-center study of perinatal outcomes". The Journal of Maternal-Fetal and Neonatal Medicine. 23 (6): 506–10. doi:10.3109/14767050903214590. PMID 19718582. S2CID 37447326.
^ abRoyal College of Obstetricians and Gynaecologists (16 November 2016). "Management of Monochorionic Twin Pregnancy". BJOG. 124 (1): e1–e45. doi:10.1111/1471-0528.14188. PMID 27862859.
^Dias, T; Mahsud‐Dornan, S.; Bhide, A.; Papageorghiou, A. T.; Thilaganathan, B. (12 January 2010). "Cord entanglement and perinatal outcome in monoamniotic twin pregnancies". Ultrasound Obstet Gynecol. 35 (2): 201–204. doi:10.1002/uog.7501. PMID 20069540.
^American College of Obstetricians and Gynecologists (ACOG) (May 2014). "Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies". ACOG practice bulletin, no. 144. {{cite journal}}: Cite journal requires |journal= (help)
^Khandelwal, Meena; Revanasiddappa, Vanitha B.; Moreno, Sindy C.; Simpkins, Gunda; Weiner, Stuart; Westover, Thomas (May 2016). "Monoamniotic Monochorionic Twins—Can They Be Delivered Safely Via Vaginal Route?". Obstetrics & Gynecology. 127 (Supplement 1): 3S. doi:10.1097/01.AOG.0000483625.92567.88. S2CID 25507744.
March 16, 2024
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Monoamniotic twins are identical or semi identical twins that share the same amniotic sac within their mother s uterus 1 Monoamniotic twins are always monochorionic and are usually termed Monoamniotic Monochorionic MoMo or Mono Mono twins 1 2 They share the placenta but have two separate umbilical cords Monoamniotic twins develop when an embryo does not split until after formation of the amniotic sac 1 at about 9 13 days after fertilization 3 Monoamniotic triplets or other monoamniotic multiples 4 are possible but extremely rare 1 Other obscure possibilities include multiples sets where monoamniotic twins are part of a larger gestation such as triplets quadruplets or more Various types of chorionicity and amniosity how the baby s sac looks in monozygotic one egg identical twins as a result of when the blastocyst or embryo splits Contents 1 Occurrence 2 Complications 3 Diagnosis 4 Treatment 5 See also 6 ReferencesOccurrence editMonoamniotic twins are rare with an occurrence of 1 in 35 000 to 1 in 60 000 pregnancies 1 5 Complications editThe survival rate for monoamniotic twins has been shown to be as high as 81 6 to 95 7 in 2009 with aggressive fetal monitoring although previously reported as being between 50 1 and 60 4 Causes of mortality and morbidity include Cord entanglement The close proximity and absence of amniotic membrane separating the two umbilical cords makes it particularly easy for the twins to become entangled in each other s cords hindering fetal movement and development 4 Additionally entanglement may cause one twin to become stuck in the birth canal during labor and expulsion 1 Cord entanglement happens to some degree in almost every monoamniotic pregnancy 1 Cord compression One twin may compress the other s umbilical cord potentially stopping the flow of nutrients and blood and resulting in fetal death 1 4 Twin to twin transfusion syndrome TTTS One twin receives the majority of the nourishment causing the other twin to become undernourished TTTS is much more difficult to diagnose in monoamniotic twins than diamniotic ones since the standard method otherwise is to compare the fluid in the sacs Rather TTTS diagnosis in monoamniotic twins relies on comparing the physical development of the twins 1 Diagnosis edit nbsp Abdominal ultrasonography of monoamniotic twins at a gestational age of 15 weeks There is no sign of any membrane between the fetuses A coronal plane is shown of the twin at left and a sagittal plane of parts of the upper thorax and head is shown of the twin at right Ultrasound is the only way to detect monoamniotic monochorionic twins before birth 4 It can show the lack of a membrane between the twins after a couple of weeks gestation when the membrane would be visible if present 4 Further ultrasounds with high resolution doppler imaging and non stress tests help to assess the situation and identify potential cord problems 4 There is a correlation between having a single yolk sac and having a single amniotic sac 1 However it is difficult to detect the number of yolk sacs because the yolk sac disappears during embryogenesis 1 Cord entanglement and compression generally progress slowly allowing parents and medical caregivers to make decisions carefully 4 Treatment editOnly a few treatments can give any improvements Sulindac has been used experimentally in some monoamniotic twins lowering the amount of amniotic fluid and thereby inhibiting fetal movement This is believed to lower the risk of cord entanglement and compression However the potential side effects of the drug have been insufficiently investigated 1 4 Regular and aggressive fetal monitoring is recommended for cases of monoamniotic twins to look for cord entanglement beginning after viability Many women enter inpatient care with continuous monitoring 1 preferably in the care of a perinatologist an obstetrician that specialises in high risk pregnancies 4 However RCOG s guidelines 8 cite Dias et al 9 in observing that cord entanglement is nearly always found in monoamniotic pregnancies and it is not clearly associated with poor outcomes with most fetal deaths instead arising from twin reversed arterial perfusion or fetal anomaly The clinical guidelines of ACOG and RCOG both recommend premature delivery by cesarean section between 32 and 34 weeks 10 8 A retrospective study in 2016 argued that there is evidence vaginal delivery can be equally safe and reduce complications for some monoamniotic twins 11 but this finding has not been incorporated into clinical guidelines See also editMonochorionic twins Identical twinsReferences edit a b c d e f g h i j k l m n Monoamniotic Twins Pregnancy info net Retrieved July 9 2009 Mono Mono Twins Twin Pregnancy and Beyond Shulman LS van Vugt JM 2006 Prenatal medicine Washington DC Taylor amp Francis p 447 ISBN 0 8247 2844 0 a b c d e f g h i j MoMo Twins Monochorionic Monoamniotic Twins By Pamela Prindle Fierro About com Retrieved on July 9 2009 How rare are MoMo twins MoMoTwins org Retrieved Feb 14 2022 Hack KE Derks JB Schaap AH Lopriore E Elias SG Arabin B Eggink AJ Sollie KM Mol BW Duvekot HJ Willekes C Go AT Koopman Esseboom C Vandenbussche FP Visser GH February 2009 Perinatal outcome of monoamniotic twin pregnancies Obstetrics and Gynecology 113 2 Pt 1 353 60 doi 10 1097 AOG 0b013e318195bd57 PMID 19155906 S2CID 10186845 Baxi LV Walsh CA June 2010 Monoamniotic twins in contemporary practice a single center study of perinatal outcomes The Journal of Maternal Fetal and Neonatal Medicine 23 6 506 10 doi 10 3109 14767050903214590 PMID 19718582 S2CID 37447326 a b Royal College of Obstetricians and Gynaecologists 16 November 2016 Management of Monochorionic Twin Pregnancy BJOG 124 1 e1 e45 doi 10 1111 1471 0528 14188 PMID 27862859 Dias T Mahsud Dornan S Bhide A Papageorghiou A T Thilaganathan B 12 January 2010 Cord entanglement and perinatal outcome in monoamniotic twin pregnancies Ultrasound Obstet Gynecol 35 2 201 204 doi 10 1002 uog 7501 PMID 20069540 American College of Obstetricians and Gynecologists ACOG May 2014 Multifetal gestations twin triplet and higher order multifetal pregnancies ACOG practice bulletin no 144 a href Template Cite journal html title Template Cite journal cite journal a Cite journal requires journal help Khandelwal Meena Revanasiddappa Vanitha B Moreno Sindy C Simpkins Gunda Weiner Stuart Westover Thomas May 2016 Monoamniotic Monochorionic Twins Can They Be Delivered Safely Via Vaginal Route Obstetrics amp Gynecology 127 Supplement 1 3S doi 10 1097 01 AOG 0000483625 92567 88 S2CID 25507744 Retrieved from https en wikipedia org w index php title Monoamniotic twins amp oldid 1155260608, wikipedia, wiki, book, books, library,
