This article is missing information about relationship between this concept of cytochrome-P450s, perferably using a source from the 21st century. Please expand the article to include this information. Further details may exist on the talk page.(March 2022)
Mixed-function oxidase is the name of a family of oxidaseenzymes that catalyze a reaction in which each of the two atoms of oxygen in O2 is used for a different function in the reaction.[1]
The name "mixed-function oxidase" indicates that the enzyme oxidizes two different substrates simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and NADPH are oxidized by molecular oxygen (O2) to produce monounsaturated fatty acyl-CoA, NADP+ and 2 molecules of water.
Reactionedit
The mixed-function oxidase reaction proceeds as follows:
AH + BH2 + O2 --> AOH + B + H2O (H2O as catalyst.)
Medical significanceedit
High levels of mixed-function oxidase activity have been studied for their activation effects in human colon carcinoma cell lines,[2] to study the susceptibility to certain cancers. The research has been successful in mice but remains inconclusive in humans.[3]
Referencesedit
^ Mixed+Function+Oxygenases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Moskwa PS, Vadi H, and Drewinko B, Mixed Function Oxidase Activities of Established Human Colon Carcinoma Cell, 45, 5447-5451, November 1985
^Kellerman G, Jett JR, Luyten-Kellermann M, Moses HL, Variation of microsomal mixed function oxidase(s) and human lung cancer, Cancer (Impact Factor: 5.2). 06/2006; 45(6):1438 - 1442. DOI: 10.1002/1097-0142(19800315)45:6
mixed, function, oxidase, this, article, missing, information, about, relationship, between, this, concept, cytochrome, p450s, perferably, using, source, from, 21st, century, please, expand, article, include, this, information, further, details, exist, talk, p. This article is missing information about relationship between this concept of cytochrome P450s perferably using a source from the 21st century Please expand the article to include this information Further details may exist on the talk page March 2022 Mixed function oxidase is the name of a family of oxidase enzymes that catalyze a reaction in which each of the two atoms of oxygen in O2 is used for a different function in the reaction 1 Oxidase is a general name for enzymes that catalyze oxidations in which molecular oxygen is the electron acceptor but oxygen atoms do not appear in the oxidized product Often oxygen is reduced to either water cytochrome oxidase of the mitochondrial electron transfer chain or hydrogen peroxide dehydrogenation of fatty acyl CoA in peroxisomes Most of the oxidases are flavoproteins The name mixed function oxidase indicates that the enzyme oxidizes two different substrates simultaneously Desaturation of fatty acyl CoA in vertebrates is an example of the mixed function oxidase reaction In the process saturated fatty acyl CoA and NADPH are oxidized by molecular oxygen O2 to produce monounsaturated fatty acyl CoA NADP and 2 molecules of water Reaction editThe mixed function oxidase reaction proceeds as follows AH BH2 O2 gt AOH B H2O H2O as catalyst Medical significance editHigh levels of mixed function oxidase activity have been studied for their activation effects in human colon carcinoma cell lines 2 to study the susceptibility to certain cancers The research has been successful in mice but remains inconclusive in humans 3 References edit Mixed Function Oxygenases at the U S National Library of Medicine Medical Subject Headings MeSH Moskwa PS Vadi H and Drewinko B Mixed Function Oxidase Activities of Established Human Colon Carcinoma Cell 45 5447 5451 November 1985 Kellerman G Jett JR Luyten Kellermann M Moses HL Variation of microsomal mixed function oxidase s and human lung cancer Cancer Impact Factor 5 2 06 2006 45 6 1438 1442 DOI 10 1002 1097 0142 19800315 45 6 Portal nbsp Biology nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mixed function oxidase amp oldid 1212803574, wikipedia, wiki, book, books, library,
