The combination milbemycin oxime/lufenuron (trade names Sentinel Flavor Tabs, by Novartis Animal Health, and Program plus) is a parasite control drug in which the active ingredient, milbemycin oxime, eliminates worms, while a second active ingredient, lufenuron, arrests the development of eggs and larvae, preventing them from maturing and continuing the infestation of an animal. This combination is registered for animal use only. To achieve efficacy, the treatment is administered once monthly, together with food, in a dosage suitable for the weight of the affected animal. The usual ratio is 500 μg milbemycin oxime and 10 mg lufenuron/kg body weight. Novartis indicates the proper dosage by color-coding the packages.[1]
Several 2002 studies by Novartis demonstrate that milbemycin oxime/lufenuron compares favorably to some other treatments, such as the moxidectin injection. The combination is considered effective in the elimination of fleas, and the prevention of infection from hookworm (Ancylostoma caninum), heartworm (Dirofilaria immitis), roundworms, whipworms (Trichuris vulpis), and ascarids (Toxocara canis and Toxascaris leonina).[citation needed] The USA FDA approval for Sentinel says "Concurrent use of insecticides may be necessary".[2] It is the concurrent use of Sentinel and nitenpyram (Capstar) that has an FDA-approved indication "to kill adult fleas".[3]
Side effectsEdit
Milbemycin oxime/lufenuron can lead to a negative physical response in some animals, most severely those that have heartworm disease or weigh under 2 lbs. It is recommended that all dogs be tested for heartworm prior to taking the medication to minimize this risk. Serious side effects may include lethargy, weakness, stumbling, seizures, coma, excessive drooling, and wide dilated pupils. Less serious side effects are an upset stomach or loss of appetite, various skin irritations, and mood changes. [4]
milbemycin, oxime, lufenuron, combination, milbemycin, oxime, lufenuron, trade, names, sentinel, flavor, tabs, novartis, animal, health, program, plus, parasite, control, drug, which, active, ingredient, milbemycin, oxime, eliminates, worms, while, second, act. The combination milbemycin oxime lufenuron trade names Sentinel Flavor Tabs by Novartis Animal Health and Program plus is a parasite control drug in which the active ingredient milbemycin oxime eliminates worms while a second active ingredient lufenuron arrests the development of eggs and larvae preventing them from maturing and continuing the infestation of an animal This combination is registered for animal use only To achieve efficacy the treatment is administered once monthly together with food in a dosage suitable for the weight of the affected animal The usual ratio is 500 mg milbemycin oxime and 10 mg lufenuron kg body weight Novartis indicates the proper dosage by color coding the packages 1 Milbemycin oxime lufenuronCombination ofMilbemycin oximeEndectocideLufenuronEctoparasiticideClinical dataAHFS Drugs comFDA Professional Drug InformationIdentifiersCAS Number182005 62 5 verify Several 2002 studies by Novartis demonstrate that milbemycin oxime lufenuron compares favorably to some other treatments such as the moxidectin injection The combination is considered effective in the elimination of fleas and the prevention of infection from hookworm Ancylostoma caninum heartworm Dirofilaria immitis roundworms whipworms Trichuris vulpis and ascarids Toxocara canis and Toxascaris leonina citation needed The USA FDA approval for Sentinel says Concurrent use of insecticides may be necessary 2 It is the concurrent use of Sentinel and nitenpyram Capstar that has an FDA approved indication to kill adult fleas 3 Side effects EditMilbemycin oxime lufenuron can lead to a negative physical response in some animals most severely those that have heartworm disease or weigh under 2 lbs It is recommended that all dogs be tested for heartworm prior to taking the medication to minimize this risk Serious side effects may include lethargy weakness stumbling seizures coma excessive drooling and wide dilated pupils Less serious side effects are an upset stomach or loss of appetite various skin irritations and mood changes 4 References Edit Novartis Animal Health Sentinel Flavor Tabs NADA number 140 084 NADA number 140 204 Gollakner R Milbemycin Oxime VCA Canada Hospitals a href Template Cite web html title Template Cite web cite web a CS1 maint url status link This veterinary medicine related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Milbemycin oxime lufenuron amp oldid 1140740285, wikipedia, wiki, book, books, library,
