microrna, ncrna, that, humans, encoded, mirlet7a2, gene, mirlet7a2identifiersaliasesmirlet7a2, let7a2, mirnlet7a2, microrna, 2external, idsomim, 612142, genecards, mirlet7a2gene, location, human, chromosome, human, band11q24, 1start122, end122, expression, pat. MicroRNA let 7a 2 is a ncRNA that in humans is encoded by the MIRLET7A2 gene 3 MIRLET7A2IdentifiersAliasesMIRLET7A2 LET7A2 MIRNLET7A2 let 7a 2 microRNA let 7a 2External IDsOMIM 612142 GeneCards MIRLET7A2Gene location Human Chr Chromosome 11 human 1 Band11q24 1Start122 146 522 bp 1 End122 146 593 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonkidneyendometriumbloodstomachliverleft uterine tubebody of stomachmonocyteintestinen aMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez406882n aEnsemblENSG00000198975n aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC Chr 11 122 15 122 15 Mbn aPubMed search 2 n aWikidataView Edit HumanFunction editmicroRNAs miRNAs are short 20 24 nt non coding RNAs that are involved in post transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts pri miRNAs that can be either protein coding or non coding The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nt stem loop precursor miRNA pre miRNA which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star miRNA products The mature miRNA is incorporated into a RNA induced silencing complex RISC which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA The RefSeq represents the predicted microRNA stem loop References edit a b c GRCh38 Ensembl release 89 ENSG00000198975 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene MicroRNA let 7a 2 Retrieved 2016 03 15 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MicroRNA let 7a 2 amp oldid 1087908658, wikipedia, wiki, book, books, library,
