Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA.[2][3] The binding is affected because the effective radius of the positive charge is increased (methyl groups are larger than the hydrogen atoms they replace), reducing the strongest potential electrostatic attraction with the negatively charged DNA.
It is thought that the methylation of lysine (and arginine) on histone tails does not directly affect their binding to DNA. Rather, such methyl marks recruit other proteins that modulate chromatin structure.[4]
In Protein Data Bank files, methylated lysines are indicated by the MLY or MLZ acronyms.
Unmethylated lysine
Monomethylated: 6-N-methyllysine
Dimethylated: (6-N,6-N)dimethyllysine
Trimethylated: (6-N,6-N,6-N)trimethyllysine
Referencesedit
^Hyun, Kwangbeom; Jeon, Jongcheol; Park, Kihyun; Kim, Jaehoon (2017). "Writing, erasing and reading histone lysine methylations". Experimental & Molecular Medicine. 49 (4): e324. doi:10.1038/emm.2017.11. PMC6130214. PMID 28450737.
^Ruthenburg AJ, Allis CD, Wysocka J (January 2007). "Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark". Molecular Cell. 25 (1): 15–30. doi:10.1016/j.molcel.2006.12.014. PMID 17218268.
^Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S (August 2003). "Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains". Genes & Development. 17 (15): 1870–81. doi:10.1101/gad.1110503. PMC196235. PMID 12897054.
^Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (April 2012). "Epigenetic protein families: a new frontier for drug discovery". Nature Reviews. Drug Discovery. 11 (5): 384–400. doi:10.1038/nrd3674. PMID 22498752.
This biochemistry article is a stub. You can help Wikipedia by expanding it.
methyllysine, derivative, amino, acid, residue, lysine, where, sidechain, ammonium, group, been, methylated, more, times, such, methylated, lysines, play, important, role, epigenetics, methylation, specific, lysines, certain, histones, nucleosome, alters, bind. Methyllysine is derivative of the amino acid residue lysine where the sidechain ammonium group has been methylated one or more times 1 Such methylated lysines play an important role in epigenetics the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones which in turn affects the expression of genes on that DNA 2 3 The binding is affected because the effective radius of the positive charge is increased methyl groups are larger than the hydrogen atoms they replace reducing the strongest potential electrostatic attraction with the negatively charged DNA It is thought that the methylation of lysine and arginine on histone tails does not directly affect their binding to DNA Rather such methyl marks recruit other proteins that modulate chromatin structure 4 In Protein Data Bank files methylated lysines are indicated by the MLY or MLZ acronyms Unmethylated lysine Monomethylated 6 N methyllysine Dimethylated 6 N 6 N dimethyllysine Trimethylated 6 N 6 N 6 N trimethyllysineReferences edit Hyun Kwangbeom Jeon Jongcheol Park Kihyun Kim Jaehoon 2017 Writing erasing and reading histone lysine methylations Experimental amp Molecular Medicine 49 4 e324 doi 10 1038 emm 2017 11 PMC 6130214 PMID 28450737 Ruthenburg AJ Allis CD Wysocka J January 2007 Methylation of lysine 4 on histone H3 intricacy of writing and reading a single epigenetic mark Molecular Cell 25 1 15 30 doi 10 1016 j molcel 2006 12 014 PMID 17218268 Fischle W Wang Y Jacobs SA Kim Y Allis CD Khorasanizadeh S August 2003 Molecular basis for the discrimination of repressive methyl lysine marks in histone H3 by Polycomb and HP1 chromodomains Genes amp Development 17 15 1870 81 doi 10 1101 gad 1110503 PMC 196235 PMID 12897054 Arrowsmith CH Bountra C Fish PV Lee K Schapira M April 2012 Epigenetic protein families a new frontier for drug discovery Nature Reviews Drug Discovery 11 5 384 400 doi 10 1038 nrd3674 PMID 22498752 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Methyllysine amp oldid 1175822036, wikipedia, wiki, book, books, library,
