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Metacaspase

May 02, 2024

Metacaspases are members of the C14 class of cysteine proteases and thus related to caspases, orthocaspases and paracaspases.[1] The metacaspases are arginine/lysine-specific, in contrast to caspases, which are aspartate-specific.[2]

Structure and Phylogenetic distribution edit

Prokaryotes edit

In archea and bacteria, there are several metacaspases with a wide range of domain organizations.[3] Based on the prokaryote metacaspase diversity, orthocaspases can be considered a sub-class of metacaspases. Common for both metacaspases and orthocaspases classes is their specificity for basic residues (arginine or lysine) in the P1 position. At this moment, no structural variants have been reported where the substrate specificity would change to an acidic residue (aspartic acid), like in true caspases.

Eukaryotes edit

Metacaspases are found in plants, fungi, and "protists", but not in slime mold or animals.

Viruses edit

Viral metacaspases, which may have implications in rewiring host metabolism to enhance infection, are widespread in the ocean.[4]

Type I edit

Type I metacaspases are characterized by an amino-terminal proline or glutamine rich LSD zinc finger-like domain.[5] This type can be found in prokaryotes and eukaryotes other than animals.

Type II edit

Type II is found only in certain green algae and land plants, with one recent exception where both type I and type II metacaspases were found in the genome of Monosiga brevicollis (Choanoflagellate),[6] possibly as a result of an unusual horizontal gene transfer between two eukaryotes.This group is characterized by long linker region and the absence of an amino-terminal pro-domain.


Known functions edit

In an analogous manner to caspases, metacaspases induce programmed cell death in both plants and fungi (yeast).[7][8][9]

References edit

  1. ^ Uren AG, O'Rourke K, Aravind LA, et al. (Oct 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Molecular Cell. 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  2. ^ Vercammen D, van de Cotte B, De Jaeger G, et al. (Oct 2004). "Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine". J Biol Chem. 279 (44): 45329–36. doi:10.1074/jbc.M406329200. PMID 15326173.
  3. ^ Asplund-Samuelsson J, Bergman B, Larsson J (Nov 2012). "Prokaryotic caspase homologs: phylogenetic patterns and functional characteristics reveal considerable diversity". PLOS ONE. 7 (11): e49888. Bibcode:2012PLoSO...749888A. doi:10.1371/journal.pone.0049888. PMC 3501461. PMID 23185476.
  4. ^ Wilson W, et al. (2017). "Genomic exploration of individual giant ocean viruses". The ISME Journal. 11 (8): 1736–1745. doi:10.1038/ismej.2017.61. PMC 5520044. PMID 28498373.
  5. ^ Vercammen D, van de Cotte B, De Jaeger G, et al. (Oct 2004). "Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine". J Biol Chem. 279 (44): 45329–36. doi:10.1074/jbc.M406329200. PMID 15326173.
  6. ^ Nedelcu AM, Miles IH, Fagir AM, Karol K (Aug 2008). "Adaptive eukaryote-to-eukaryote lateral gene transfer: stress-related genes of algal origin in the closest unicellular relatives of animals". J Evol Biol. 21 (6): 1852–60. doi:10.1111/j.1420-9101.2008.01605.x. PMID 18717747.
  7. ^ Madeo F, Herker E, Maldener C, et al. (Apr 2002). "A caspase-related protease regulates apoptosis in yeast". Molecular Cell. 9 (4): 911–7. doi:10.1016/S1097-2765(02)00501-4. PMID 11983181.
  8. ^ Bozhkov PV, Suarez MF, Filonova LH, et al. (Oct 2005). "Cysteine protease mcII-Pa executes programmed cell death during plant embryogenesis". Proc Natl Acad Sci U S A. 102 (40): 14463–8. Bibcode:2005PNAS..10214463B. doi:10.1073/pnas.0506948102. PMC 1242326. PMID 16183741.
  9. ^ Khan MA, Chock PB, Stadtman ER (Nov 2005). "Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 102 (48): 17326–31. Bibcode:2005PNAS..10217326K. doi:10.1073/pnas.0508120102. PMC 1287485. PMID 16301538.

See also edit

May 02, 2024
metacaspase, members, class, cysteine, proteases, thus, related, caspases, orthocaspases, paracaspases, metacaspases, arginine, lysine, specific, contrast, caspases, which, aspartate, specific, contents, structure, phylogenetic, distribution, prokaryotes, euka. Metacaspases are members of the C14 class of cysteine proteases and thus related to caspases orthocaspases and paracaspases 1 The metacaspases are arginine lysine specific in contrast to caspases which are aspartate specific 2 Contents 1 Structure and Phylogenetic distribution 1 1 Prokaryotes 1 2 Eukaryotes 1 3 Viruses 1 3 1 Type I 1 3 2 Type II 2 Known functions 3 References 4 See alsoStructure and Phylogenetic distribution editProkaryotes edit In archea and bacteria there are several metacaspases with a wide range of domain organizations 3 Based on the prokaryote metacaspase diversity orthocaspases can be considered a sub class of metacaspases Common for both metacaspases and orthocaspases classes is their specificity for basic residues arginine or lysine in the P1 position At this moment no structural variants have been reported where the substrate specificity would change to an acidic residue aspartic acid like in true caspases Eukaryotes edit Metacaspases are found in plants fungi and protists but not in slime mold or animals Viruses edit Viral metacaspases which may have implications in rewiring host metabolism to enhance infection are widespread in the ocean 4 Type I edit Type I metacaspases are characterized by an amino terminal proline or glutamine rich LSD zinc finger like domain 5 This type can be found in prokaryotes and eukaryotes other than animals Type II edit Type II is found only in certain green algae and land plants with one recent exception where both type I and type II metacaspases were found in the genome of Monosiga brevicollis Choanoflagellate 6 possibly as a result of an unusual horizontal gene transfer between two eukaryotes This group is characterized by long linker region and the absence of an amino terminal pro domain Known functions editIn an analogous manner to caspases metacaspases induce programmed cell death in both plants and fungi yeast 7 8 9 References edit Uren AG O Rourke K Aravind LA et al Oct 2000 Identification of paracaspases and metacaspases two ancient families of caspase like proteins one of which plays a key role in MALT lymphoma Molecular Cell 6 4 961 7 doi 10 1016 S1097 2765 05 00086 9 PMID 11090634 Vercammen D van de Cotte B De Jaeger G et al Oct 2004 Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine J Biol Chem 279 44 45329 36 doi 10 1074 jbc M406329200 PMID 15326173 Asplund Samuelsson J Bergman B Larsson J Nov 2012 Prokaryotic caspase homologs phylogenetic patterns and functional characteristics reveal considerable diversity PLOS ONE 7 11 e49888 Bibcode 2012PLoSO 749888A doi 10 1371 journal pone 0049888 PMC 3501461 PMID 23185476 Wilson W et al 2017 Genomic exploration of individual giant ocean viruses The ISME Journal 11 8 1736 1745 doi 10 1038 ismej 2017 61 PMC 5520044 PMID 28498373 Vercammen D van de Cotte B De Jaeger G et al Oct 2004 Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine J Biol Chem 279 44 45329 36 doi 10 1074 jbc M406329200 PMID 15326173 Nedelcu AM Miles IH Fagir AM Karol K Aug 2008 Adaptive eukaryote to eukaryote lateral gene transfer stress related genes of algal origin in the closest unicellular relatives of animals J Evol Biol 21 6 1852 60 doi 10 1111 j 1420 9101 2008 01605 x PMID 18717747 Madeo F Herker E Maldener C et al Apr 2002 A caspase related protease regulates apoptosis in yeast Molecular Cell 9 4 911 7 doi 10 1016 S1097 2765 02 00501 4 PMID 11983181 Bozhkov PV Suarez MF Filonova LH et al Oct 2005 Cysteine protease mcII Pa executes programmed cell death during plant embryogenesis Proc Natl Acad Sci U S A 102 40 14463 8 Bibcode 2005PNAS 10214463B doi 10 1073 pnas 0506948102 PMC 1242326 PMID 16183741 Khan MA Chock PB Stadtman ER Nov 2005 Knockout of caspase like gene YCA1 abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae Proc Natl Acad Sci U S A 102 48 17326 31 Bibcode 2005PNAS 10217326K doi 10 1073 pnas 0508120102 PMC 1287485 PMID 16301538 See also editThe Proteolysis Map MALT1 Retrieved from https en wikipedia org w index php title Metacaspase amp oldid 1073207513, wikipedia, wiki, book, books, library,

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