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Melissa Haendel

Melissa Anne Haendel is an American bioinformaticist who is the Chief Research Informatics Officer of the Anschutz Medical Campus of the University of Colorado as well as a Professor of Biochemistry and Molecular Genetics and the Marsico Chair in Data Science.[1][2] She serves as Director of the Center for Data to Health (CD2H). Her research makes use of data to improve the discovery and diagnosis of diseases. During the COVID-19 pandemic, Haendel joined with the National Institutes of Health to launch the National COVID Cohort Collaborative (N3C), which looks to identify the risk factors that can predict severity of disease outcome and help to identify treatments.

Melissa Anne Haendel
Haendel in 2020
Alma materReed College
University of Wisconsin–Madison
Known forBioinformatics
Scientific career
InstitutionsAnschutz Medical Campus
Oregon Health & Science University
Oregon State University
ThesisIdentification and characterization of the novel gene, axotrophin, using an in vitro gene trap preselection method (1999)

Early life and education edit

Haendel earned her undergraduate degree in chemistry at Reed College.[3] Her undergraduate dissertation looked at designing pharmaceuticals using molecular electrostatic potentials (MEPs) to construct quantitative structure-activity relationships.[4] She moved to the University of Wisconsin–Madison for her graduate studies, where she used in vitro gene trapping to study the gene axotrophin.[5] Her early career focussed on genetics and molecular biology.[6] In 2000 she moved to the University of Oregon as a postdoctoral researcher studying the role of thyroid hormones in the neural development of zebrafish.

Research and career edit

 
Haendel speaks at the National Human Genome Research Institute in 2016

Haendel started working in healthcare informatics in 2004.[6] She switched the focus of her research from neuroscience and the biology of zebrafish to the development of resources for the Oregon Health & Science University library. She was promoted to Associate Professor of Medical Informatics in 2015.[citation needed]

Haendel's research considers ontology development, biocuration and data harmonization.[6] Biocuration assembles information from patient records, research outputs and medical literature to create a quality-controlled, computable format.[6] She was previously the Director of Translational Data Science at the Linus Pauling Institute.[7] She currently holds the position of Chief Research Informatics Officer at the University of Colorado Anschutz Medical Campus.[8]

Haendel believes that a globally consistent set of criteria, more comprehensive data collection, sharing and analysis will help to diagnose rare diseases.[9] Rare diseases are thought to impact 10% of the global population, meaning that there are considerable numbers of patients who are underserved by their healthcare systems.[10] In 2019, Haendel and the CD2H were awarded almost $9 million to make data related to cancer research more centralised and organised.[11] The Center for Cancer Data Harmonization makes use of a cloud-based portal to share data between physicians and cancer researchers across the country.[12]

During the COVID-19 pandemic, the United States had no standardised means to collect and share clinical data.[13][14] Haendel was concerned that the number of deaths and infections were not being accurately counted, and that this might compromise safe reopening.[15] In June 2020, Haendel formed the National COVID Cohort Collaborative (N3C),[16] which collates and analyses the medical record data of people with coronavirus disease.[17] The N3C looks to identify the risk factors that can predict severity of coronavirus disease and help to identify potential treatments.[17] It has work streams in data partnership, phenotypes, collaborative analytics, data harmonisation and data synthesis.[citation needed]

Selected publications edit

  • Mungall, Christopher J; Torniai, Carlo; Gkoutos, Georgios V; Lewis, Suzanna E; Haendel, Melissa A (2012). "Uberon, an integrative multi-species anatomy ontology". Genome Biology. 13 (1): R5. doi:10.1186/gb-2012-13-1-r5. ISSN 1465-6906. PMC 3334586. PMID 22293552. S2CID 15453742.
  • Day-Richter, J.; Harris, M. A.; Haendel, M.; Lewis, S. (2007-06-01). "OBO-Edit an ontology editor for biologists". Bioinformatics. 23 (16): 2198–2200. doi:10.1093/bioinformatics/btm112. ISSN 1367-4803. PMID 17545183.
  • Shimoyama, Mary; Dwinell, Melinda; Jacob, Howard (2009-08-05). "Multiple Ontologies for Integrating Complex Phenotype Datasets". Nature Precedings. doi:10.1038/npre.2009.3554. ISSN 1756-0357.

References edit

  1. ^ "Melissa Haendel, PhD".
  2. ^ "Melissa A. Haendel joins CU Anschutz as Chief Research Informatics Officer".
  3. ^ "Melissa A. Haendel Ph.D. | OHSU People | OHSU". www.ohsu.edu. Retrieved 2020-06-28.
  4. ^ Haendel, Melissa Anne (1991). Designing drugs: a new method using MEPs in constructing QSARs (Thesis). OCLC 268802607.
  5. ^ Haendel, Melissa A (1999). Identification and characterization of the novel gene, axotrophin, using an in vitro gene trap preselection method. OCLC 608882841.
  6. ^ a b c d "Melissa Haendel, PhD | AMIA". www.amia.org. Retrieved 2020-06-28.
  7. ^ "Melissa A. Haendel". Linus Pauling Institute. 2018-03-21. Retrieved 2020-06-28.
  8. ^ "Melissa A. Haendel joins CU Anschutz as Chief Research Informatics Officer". CU Anschutz. 2021-03-04. Retrieved 2022-05-25.
  9. ^ "Scientists suggest new solution to the rare-disease problem". EurekAlert!. Retrieved 2020-06-28.
  10. ^ Haendel, Melissa; Vasilevsky, Nicole; Unni, Deepak (1 February 2020). "How many rare diseases are there?". Nature Reviews Drug Discovery. 19 (2): 77–78. doi:10.1038/D41573-019-00180-Y. ISSN 1474-1776. PMC 7771654. PMID 32020066. Wikidata Q89532791.
  11. ^ "OSU awarded $8.8M grant to make cancer research accessible". KEZI News. Retrieved 2020-06-28.
  12. ^ "Oregon State to help lead effort to make cancer research data more useful and accessible". Life at OSU. 2019-10-15. Retrieved 2020-06-28.
  13. ^ sources, KTVZ news (2020-06-22). "OSU to use power of big data to help fight against COVID-19". KTVZ. Retrieved 2020-06-28.
  14. ^ "Enlisting big data to accelerate the COVID-19 fight - News". UAB News. Retrieved 2020-06-28.
  15. ^ Staff, Lincoln Graves, KATU (2020-05-18). "Accurate data on coronavirus still lacking in many areas". KATU. Retrieved 2020-06-28.{{cite web}}: CS1 maint: multiple names: authors list (link)
  16. ^ "N3C Team". NIH NCATS.
  17. ^ a b "NIH launches analytics platform to harness nationwide COVID-19 patient". National Center for Advancing Translational Sciences. 2020-06-15. Retrieved 2020-06-28.

melissa, haendel, melissa, anne, haendel, american, bioinformaticist, chief, research, informatics, officer, anschutz, medical, campus, university, colorado, well, professor, biochemistry, molecular, genetics, marsico, chair, data, science, serves, director, c. Melissa Anne Haendel is an American bioinformaticist who is the Chief Research Informatics Officer of the Anschutz Medical Campus of the University of Colorado as well as a Professor of Biochemistry and Molecular Genetics and the Marsico Chair in Data Science 1 2 She serves as Director of the Center for Data to Health CD2H Her research makes use of data to improve the discovery and diagnosis of diseases During the COVID 19 pandemic Haendel joined with the National Institutes of Health to launch the National COVID Cohort Collaborative N3C which looks to identify the risk factors that can predict severity of disease outcome and help to identify treatments Melissa Anne HaendelHaendel in 2020Alma materReed College University of Wisconsin MadisonKnown forBioinformaticsScientific careerInstitutionsAnschutz Medical Campus Oregon Health amp Science University Oregon State UniversityThesisIdentification and characterization of the novel gene axotrophin using an in vitro gene trap preselection method 1999 Contents 1 Early life and education 2 Research and career 3 Selected publications 4 ReferencesEarly life and education editHaendel earned her undergraduate degree in chemistry at Reed College 3 Her undergraduate dissertation looked at designing pharmaceuticals using molecular electrostatic potentials MEPs to construct quantitative structure activity relationships 4 She moved to the University of Wisconsin Madison for her graduate studies where she used in vitro gene trapping to study the gene axotrophin 5 Her early career focussed on genetics and molecular biology 6 In 2000 she moved to the University of Oregon as a postdoctoral researcher studying the role of thyroid hormones in the neural development of zebrafish Research and career edit nbsp Haendel speaks at the National Human Genome Research Institute in 2016 Haendel started working in healthcare informatics in 2004 6 She switched the focus of her research from neuroscience and the biology of zebrafish to the development of resources for the Oregon Health amp Science University library She was promoted to Associate Professor of Medical Informatics in 2015 citation needed Haendel s research considers ontology development biocuration and data harmonization 6 Biocuration assembles information from patient records research outputs and medical literature to create a quality controlled computable format 6 She was previously the Director of Translational Data Science at the Linus Pauling Institute 7 She currently holds the position of Chief Research Informatics Officer at the University of Colorado Anschutz Medical Campus 8 Haendel believes that a globally consistent set of criteria more comprehensive data collection sharing and analysis will help to diagnose rare diseases 9 Rare diseases are thought to impact 10 of the global population meaning that there are considerable numbers of patients who are underserved by their healthcare systems 10 In 2019 Haendel and the CD2H were awarded almost 9 million to make data related to cancer research more centralised and organised 11 The Center for Cancer Data Harmonization makes use of a cloud based portal to share data between physicians and cancer researchers across the country 12 During the COVID 19 pandemic the United States had no standardised means to collect and share clinical data 13 14 Haendel was concerned that the number of deaths and infections were not being accurately counted and that this might compromise safe reopening 15 In June 2020 Haendel formed the National COVID Cohort Collaborative N3C 16 which collates and analyses the medical record data of people with coronavirus disease 17 The N3C looks to identify the risk factors that can predict severity of coronavirus disease and help to identify potential treatments 17 It has work streams in data partnership phenotypes collaborative analytics data harmonisation and data synthesis citation needed Selected publications editMungall Christopher J Torniai Carlo Gkoutos Georgios V Lewis Suzanna E Haendel Melissa A 2012 Uberon an integrative multi species anatomy ontology Genome Biology 13 1 R5 doi 10 1186 gb 2012 13 1 r5 ISSN 1465 6906 PMC 3334586 PMID 22293552 S2CID 15453742 Day Richter J Harris M A Haendel M Lewis S 2007 06 01 OBO Edit an ontology editor for biologists Bioinformatics 23 16 2198 2200 doi 10 1093 bioinformatics btm112 ISSN 1367 4803 PMID 17545183 Shimoyama Mary Dwinell Melinda Jacob Howard 2009 08 05 Multiple Ontologies for Integrating Complex Phenotype Datasets Nature Precedings doi 10 1038 npre 2009 3554 ISSN 1756 0357 References edit Melissa Haendel PhD Melissa A Haendel joins CU Anschutz as Chief Research Informatics Officer Melissa A Haendel Ph D OHSU People OHSU www ohsu edu Retrieved 2020 06 28 Haendel Melissa Anne 1991 Designing drugs a new method using MEPs in constructing QSARs Thesis OCLC 268802607 Haendel Melissa A 1999 Identification and characterization of the novel gene axotrophin using an in vitro gene trap preselection method OCLC 608882841 a b c d Melissa Haendel PhD AMIA www amia org Retrieved 2020 06 28 Melissa A Haendel Linus Pauling Institute 2018 03 21 Retrieved 2020 06 28 Melissa A Haendel joins CU Anschutz as Chief Research Informatics Officer CU Anschutz 2021 03 04 Retrieved 2022 05 25 Scientists suggest new solution to the rare disease problem EurekAlert Retrieved 2020 06 28 Haendel Melissa Vasilevsky Nicole Unni Deepak 1 February 2020 How many rare diseases are there Nature Reviews Drug Discovery 19 2 77 78 doi 10 1038 D41573 019 00180 Y ISSN 1474 1776 PMC 7771654 PMID 32020066 Wikidata Q89532791 OSU awarded 8 8M grant to make cancer research accessible KEZI News Retrieved 2020 06 28 Oregon State to help lead effort to make cancer research data more useful and accessible Life at OSU 2019 10 15 Retrieved 2020 06 28 sources KTVZ news 2020 06 22 OSU to use power of big data to help fight against COVID 19 KTVZ Retrieved 2020 06 28 Enlisting big data to accelerate the COVID 19 fight News UAB News Retrieved 2020 06 28 Staff Lincoln Graves KATU 2020 05 18 Accurate data on coronavirus still lacking in many areas KATU Retrieved 2020 06 28 a href Template Cite web html title Template Cite web cite web a CS1 maint multiple names authors list link N3C Team NIH NCATS a b NIH launches analytics platform to harness nationwide COVID 19 patient National Center for Advancing Translational Sciences 2020 06 15 Retrieved 2020 06 28 Retrieved from https en wikipedia org w index php title Melissa Haendel amp oldid 1188172549, wikipedia, wiki, book, books, library,

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