This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000156009 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Melanoma antigen family A, 8". Retrieved 2014-08-25.
Further readingEdit
De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540. S2CID 11331427.
Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
Serrano A, Lethé B, Delroisse JM, Lurquin C, De Plaen E, Brasseur F, Rimoldi D, Boon T (November 1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". International Journal of Cancer. 83 (5): 664–9. doi:10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V. PMID 10521804.
melanoma, antigen, family, melanoma, antigen, family, protein, that, humans, encoded, magea8, gene, magea8identifiersaliasesmagea8, mage8, mage, family, member, a8external, idsomim, 300341, homologene, 74553, genecards, magea8gene, location, human, chromosome,. Melanoma antigen family A 8 is a protein that in humans is encoded by the MAGEA8 gene 3 MAGEA8IdentifiersAliasesMAGEA8 CT1 8 MAGE8 Melanoma antigen family a 8 MAGE family member A8External IDsOMIM 300341 HomoloGene 74553 GeneCards MAGEA8Gene location Human Chr X chromosome human 1 BandXq28Start149 881 141 bp 1 End149 885 835 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentagastric mucosacervixcanal of the cervixfundusleft uterine tubethoracic aortaascending aortamyometriumvaginan aMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding molecular functionCellular componentcellular componentBiological processbiological processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez4107n aEnsemblENSG00000156009n aUniProtP43361n aRefSeq mRNA NM 005364NM 001166400NM 001166401n aRefSeq protein NP 001159872NP 001159873NP 005355n aLocation UCSC Chr X 149 88 149 89 Mbn aPubMed search 2 n aWikidataView Edit HumanFunction EditThis gene is a member of the MAGEA gene family The members of this family encode proteins with 50 to 80 sequence identity to each other The promoters and first exons of the MAGEA genes show considerable variability suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls The MAGEA genes are clustered at chromosomal location Xq28 They have been implicated in some hereditary disorders such as dyskeratosis congenita Multiple alternatively spliced variants encoding the same protein have been identified References Edit a b c GRCh38 Ensembl release 89 ENSG00000156009 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Melanoma antigen family A 8 Retrieved 2014 08 25 Further reading EditDe Plaen E Arden K Traversari C Gaforio JJ Szikora JP De Smet C Brasseur F van der Bruggen P Lethe B Lurquin C 1994 Structure chromosomal localization and expression of 12 genes of the MAGE family Immunogenetics 40 5 360 9 doi 10 1007 BF01246677 PMID 7927540 S2CID 11331427 Rogner UC Wilke K Steck E Korn B Poustka A October 1995 The melanoma antigen gene MAGE family is clustered in the chromosomal band Xq28 Genomics 29 3 725 31 doi 10 1006 geno 1995 9945 PMID 8575766 Serrano A Lethe B Delroisse JM Lurquin C De Plaen E Brasseur F Rimoldi D Boon T November 1999 Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries International Journal of Cancer 83 5 664 9 doi 10 1002 SICI 1097 0215 19991126 83 5 lt 664 AID IJC16 gt 3 0 CO 2 V PMID 10521804 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Melanoma antigen family a 8 amp oldid 1108524814, wikipedia, wiki, book, books, library,
