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Wikipedia

Mebanazine

Mebanazine (trade name Actomol) is a monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was previously used as an antidepressant in the 1960s, but has since been withdrawn due to hepatotoxicity.[1][2][3]

Mebanazine
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-phenylethylhydrazine
CAS Number
  • 65-64-5
PubChem CID
  • 6179
ChemSpider
  • 5944
UNII
  • Z5R55CJ4CG
ChEMBL
  • ChEMBL1909283
CompTox Dashboard (EPA)
  • DTXSID50859848
ECHA InfoCard100.000.559
Chemical and physical data
FormulaC8H12N2
Molar mass136.198 g·mol−1

Mebanazine in animals is claimed to be a more potent MAOI than pheniprazine with a greater therapeutic index.[4]

See also Edit

References Edit

  1. ^ Gilmour SJ (September 1965). "Clinical trial of mebanazine--a new monoamine oxidase inhibitor". The British Journal of Psychiatry. 111 (478): 899–902. doi:10.1192/bjp.111.478.899. PMID 5889715. S2CID 46651861.
  2. ^ Barker JC, Jan IA, Enoch MD (November 1965). "A controlled trial of mebanazine ('Actomol') in depression". The British Journal of Psychiatry. 111 (480): 1095–100. doi:10.1192/bjp.111.480.1095. PMID 5320546. S2CID 6803488.
  3. ^ Knott F (1965). "A preliminary trial of mebanazine in depressive states". The Journal of New Drugs. 5 (6): 345–7. doi:10.1002/j.1552-4604.1965.tb00259.x. PMID 5327282.[permanent dead link]
  4. ^ Biel, J. H. (1967). "Annual Reports in Medicinal Chemistry". Chapter 2. Antidepressants, Stimulants, Hallucinogens. Annual Reports in Medicinal Chemistry. Vol. 2. Elsevier. pp. 11–23. doi:10.1016/S0065-7743(08)61499-2. ISBN 9780120405022.


mebanazine, trade, name, actomol, monoamine, oxidase, inhibitor, maoi, hydrazine, chemical, class, that, previously, used, antidepressant, 1960s, since, been, withdrawn, hepatotoxicity, clinical, dataroutes, ofadministrationoralatc, codenonelegal, statuslegal,. Mebanazine trade name Actomol is a monoamine oxidase inhibitor MAOI of the hydrazine chemical class that was previously used as an antidepressant in the 1960s but has since been withdrawn due to hepatotoxicity 1 2 3 MebanazineClinical dataRoutes ofadministrationOralATC codenoneLegal statusLegal statusIn general Prescription only IdentifiersIUPAC name 1 phenylethylhydrazineCAS Number65 64 5PubChem CID6179ChemSpider5944UNIIZ5R55CJ4CGChEMBLChEMBL1909283CompTox Dashboard EPA DTXSID50859848ECHA InfoCard100 000 559Chemical and physical dataFormulaC 8H 12N 2Molar mass136 198 g mol 1Mebanazine in animals is claimed to be a more potent MAOI than pheniprazine with a greater therapeutic index 4 See also EditHydrazine antidepressant References Edit Gilmour SJ September 1965 Clinical trial of mebanazine a new monoamine oxidase inhibitor The British Journal of Psychiatry 111 478 899 902 doi 10 1192 bjp 111 478 899 PMID 5889715 S2CID 46651861 Barker JC Jan IA Enoch MD November 1965 A controlled trial of mebanazine Actomol in depression The British Journal of Psychiatry 111 480 1095 100 doi 10 1192 bjp 111 480 1095 PMID 5320546 S2CID 6803488 Knott F 1965 A preliminary trial of mebanazine in depressive states The Journal of New Drugs 5 6 345 7 doi 10 1002 j 1552 4604 1965 tb00259 x PMID 5327282 permanent dead link Biel J H 1967 Annual Reports in Medicinal Chemistry Chapter 2 Antidepressants Stimulants Hallucinogens Annual Reports in Medicinal Chemistry Vol 2 Elsevier pp 11 23 doi 10 1016 S0065 7743 08 61499 2 ISBN 9780120405022 This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mebanazine amp oldid 1148467170, wikipedia, wiki, book, books, library,

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