Steinberg proposed that when cells form distinct tissues, specific cell-cell adhesion between cells from the same tissue can drive the separation. He further proposed that a difference in level of cell adhesion molecules expression between two cell types was sufficient to drive the separation.[6] He confirmed these predictions in a model system in which adhesion between cells of a cultured line of mouse cells was controlled by genetic expression levels of cadherin.[7]
Steinberg pioneered work in characterizing the physical properties of cells and tissues. He proposed that cell-cell adhesion drives tissue rounding up and, comparing tissues to liquids, he proposed that tissues have a surface tension. To measure tissue surface tension, he participated in building a compression device for rounded cell aggregates,[8][9] and in sessile droplet experiments in which aggregates of cells were centrifuged at 37 degrees until their shapes reached equilibrium.[10][11]
Later experiments led him to conclude that differential adhesion, and an adhesion gradient, guide the salamander pronephric duct to the cloaca during embryonic development.[12]
Steinberg completed his BS at Amherst College in 1952, his PhD in zoology at the University of Minnesota in 1956, was a professor of biology at Johns Hopkins University from 1958 to 1966, and transferred to Princeton University in 1966, becoming professor emeritus in 2005.
^Steinberg, Malcolm S. (1962). "On the mechanism of tissue reconstruction by dissociated cells, I. Population kinetics, differential adhesiveness, and the absence of directed migration". Proc Natl Acad Sci USA. 48 (9): 1577–1582. Bibcode:1962PNAS...48.1577S. doi:10.1073/pnas.48.9.1577. PMC221002. PMID 13916689.
^Steinberg, Malcolm S. (1962). "Mechanism of tissue reconstruction by dissociated cells. II. Time-course of events". Science. 137 (3532): 762–3. Bibcode:1962Sci...137..762S. doi:10.1126/science.137.3532.762. PMID 13916688. S2CID 29591598. Retrieved May 19, 2021.
^Steinberg, Malcolm S. (1963). "Reconstruction of tissues by dissociated cells. Some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation". Science. 141 (3579): 401–8. doi:10.1126/science.141.3579.401. PMID 13983728. Retrieved May 19, 2021.
^Steinberg, Malcolm S. (1970). "Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells". J Exp Zool. 173 (4): 395–433. Bibcode:1970JEZ...173..395S. doi:10.1002/jez.1401730406. PMID 5429514. Retrieved May 19, 2021.
^Steinberg, Malcolm S. (1975). "Adhesion-guided multicellular assembly: a commentary upon the postulates, real and imagined, of the differential adhesion hypothesis, with special attention to computer simulations of cell sorting". J Theor Biol. 55 (2): 431–43. Bibcode:1975JThBi..55..431S. doi:10.1016/s0022-5193(75)80091-9. PMID 1207170. Retrieved May 19, 2021.
^Steinberg, Malcolm S.; Takeichi, Masatoshi (1994). "Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression". Proc Natl Acad Sci USA. 91 (1): 206–9. Bibcode:1994PNAS...91..206S. doi:10.1073/pnas.91.1.206. PMC42915. PMID 8278366.
^Foty, Ramsey A.; Pfleger, Cathie M.; Forgacs, Gabor; Steinberg, Malcolm S. (1996). "Surface tensions of embryonic tissues predict their mutual envelopment behavior". Development. 122 (5): 1611–20. doi:10.1242/dev.122.5.1611. PMID 8625847. Retrieved May 19, 2021.
^Davis, Grayson S.; Phillips, Herbert M.; Steinberg, Malcolm S. (1997). "Germ-layer surface tensions and "tissue affinities" in Rana pipiens gastrulae: quantitative measurements". Dev Biol. 192 (2): 630–44. doi:10.1006/dbio.1997.8741. PMID 9441694.
^Phillips, Herbert M.; Steinberg, Malcolm S. (1969). "Equilibrium measurements of embryonic chick cell adhesiveness. I. Shape equilibrium in centrifugal fields". Proc Natl Acad Sci USA. 64 (1): 1212–7. Bibcode:1969PNAS...64..121P. doi:10.1073/pnas.64.1.121. PMC286135. PMID 5262993.
^Phillips, Herbert M.; Steinberg, Malcolm S. (1978). "Embryonic tissues as elasticoviscous liquids. I. Rapid and slow shape changes in centrifuged cell aggregates". J Cell Sci. 30: 1–20. doi:10.1242/jcs.30.1.1. PMID 649680. Retrieved May 19, 2021.
^Steinberg, Malcolm S.; Poole, Thomas J. (1981). "Strategies for specifying form and pattern: adhesion-guided multicellular assembly". Philos Trans R Soc Lond B Biol Sci. 295 (1078): 451–60. Bibcode:1981RSPTB.295..451S. doi:10.1098/rstb.1981.0153. PMID 6117905. Retrieved May 19, 2021.
This article about a biologist from the United States is a stub. You can help Wikipedia by expanding it.
malcolm, steinberg, this, article, needs, additional, citations, verification, please, help, improve, this, article, adding, citations, reliable, sources, unsourced, material, challenged, removed, find, sources, news, newspapers, books, scholar, jstor, septemb. This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Malcolm Steinberg news newspapers books scholar JSTOR September 2012 Learn how and when to remove this message Malcolm Saul Steinberg June 1 1930 February 7 2012 was an American biologist 1 who proposed the differential adhesion hypothesis as a mechanism explaining cell sorting during embryogenesis and cancer 2 3 4 5 Steinberg proposed that when cells form distinct tissues specific cell cell adhesion between cells from the same tissue can drive the separation He further proposed that a difference in level of cell adhesion molecules expression between two cell types was sufficient to drive the separation 6 He confirmed these predictions in a model system in which adhesion between cells of a cultured line of mouse cells was controlled by genetic expression levels of cadherin 7 Steinberg pioneered work in characterizing the physical properties of cells and tissues He proposed that cell cell adhesion drives tissue rounding up and comparing tissues to liquids he proposed that tissues have a surface tension To measure tissue surface tension he participated in building a compression device for rounded cell aggregates 8 9 and in sessile droplet experiments in which aggregates of cells were centrifuged at 37 degrees until their shapes reached equilibrium 10 11 Later experiments led him to conclude that differential adhesion and an adhesion gradient guide the salamander pronephric duct to the cloaca during embryonic development 12 Steinberg completed his BS at Amherst College in 1952 his PhD in zoology at the University of Minnesota in 1956 was a professor of biology at Johns Hopkins University from 1958 to 1966 and transferred to Princeton University in 1966 becoming professor emeritus in 2005 References edit Obituary Steinberg Malcolm S 1962 On the mechanism of tissue reconstruction by dissociated cells I Population kinetics differential adhesiveness and the absence of directed migration Proc Natl Acad Sci USA 48 9 1577 1582 Bibcode 1962PNAS 48 1577S doi 10 1073 pnas 48 9 1577 PMC 221002 PMID 13916689 Steinberg Malcolm S 1962 Mechanism of tissue reconstruction by dissociated cells II Time course of events Science 137 3532 762 3 Bibcode 1962Sci 137 762S doi 10 1126 science 137 3532 762 PMID 13916688 S2CID 29591598 Retrieved May 19 2021 Steinberg Malcolm S 1963 Reconstruction of tissues by dissociated cells Some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation Science 141 3579 401 8 doi 10 1126 science 141 3579 401 PMID 13983728 Retrieved May 19 2021 Steinberg Malcolm S 1970 Does differential adhesion govern self assembly processes in histogenesis Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells J Exp Zool 173 4 395 433 Bibcode 1970JEZ 173 395S doi 10 1002 jez 1401730406 PMID 5429514 Retrieved May 19 2021 Steinberg Malcolm S 1975 Adhesion guided multicellular assembly a commentary upon the postulates real and imagined of the differential adhesion hypothesis with special attention to computer simulations of cell sorting J Theor Biol 55 2 431 43 Bibcode 1975JThBi 55 431S doi 10 1016 s0022 5193 75 80091 9 PMID 1207170 Retrieved May 19 2021 Steinberg Malcolm S Takeichi Masatoshi 1994 Experimental specification of cell sorting tissue spreading and specific spatial patterning by quantitative differences in cadherin expression Proc Natl Acad Sci USA 91 1 206 9 Bibcode 1994PNAS 91 206S doi 10 1073 pnas 91 1 206 PMC 42915 PMID 8278366 Foty Ramsey A Pfleger Cathie M Forgacs Gabor Steinberg Malcolm S 1996 Surface tensions of embryonic tissues predict their mutual envelopment behavior Development 122 5 1611 20 doi 10 1242 dev 122 5 1611 PMID 8625847 Retrieved May 19 2021 Davis Grayson S Phillips Herbert M Steinberg Malcolm S 1997 Germ layer surface tensions and tissue affinities in Rana pipiens gastrulae quantitative measurements Dev Biol 192 2 630 44 doi 10 1006 dbio 1997 8741 PMID 9441694 Phillips Herbert M Steinberg Malcolm S 1969 Equilibrium measurements of embryonic chick cell adhesiveness I Shape equilibrium in centrifugal fields Proc Natl Acad Sci USA 64 1 1212 7 Bibcode 1969PNAS 64 121P doi 10 1073 pnas 64 1 121 PMC 286135 PMID 5262993 Phillips Herbert M Steinberg Malcolm S 1978 Embryonic tissues as elasticoviscous liquids I Rapid and slow shape changes in centrifuged cell aggregates J Cell Sci 30 1 20 doi 10 1242 jcs 30 1 1 PMID 649680 Retrieved May 19 2021 Steinberg Malcolm S Poole Thomas J 1981 Strategies for specifying form and pattern adhesion guided multicellular assembly Philos Trans R Soc Lond B Biol Sci 295 1078 451 60 Bibcode 1981RSPTB 295 451S doi 10 1098 rstb 1981 0153 PMID 6117905 Retrieved May 19 2021 nbsp nbsp This article about a biologist from the United States is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Malcolm Steinberg amp oldid 1193458104, wikipedia, wiki, book, books, library,
