This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, NAD+-malic enzyme, and NAD+-linked malic enzyme. This enzyme participates in pyruvate metabolism.
Structural studiesEdit
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DO8, 1EFK, 1EFL, 1GZ3, 1LLQ, 1O0S, 1PJ2, 1PJ3, 1PJ4, 1PJL, 1QR6, 1WW8, and 2DVM.
Kaufman S, Korkes S, Del Campillo A (1951). "Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V Further studies of the "malic" enzyme of Lactobacillus arabinosus". J. Biol. Chem. 192: 301–312. PMID 14917678.
malate, dehydrogenase, oxaloacetate, decarboxylating, enzymology, malate, dehydrogenase, oxaloacetate, decarboxylating, enzyme, that, catalyzes, chemical, reaction, belowmalate, dehydrogenase, oxaloacetate, decarboxylating, malic, enzyme, tetramer, humanidenti. In enzymology a malate dehydrogenase oxaloacetate decarboxylating EC 1 1 1 38 is an enzyme that catalyzes the chemical reaction belowmalate dehydrogenase oxaloacetate decarboxylating malic enzyme tetramer HumanIdentifiersEC no 1 1 1 38CAS no 9080 52 8DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins S malate NAD displaystyle rightleftharpoons pyruvate CO2 NADHThus the two substrates of this enzyme are S malate and NAD whereas its 3 products are pyruvate CO2 and NADH This enzyme belongs to the family of oxidoreductases specifically those acting on the CH OH group of donor with NAD or NADP as acceptor The systematic name of this enzyme class is S malate NAD oxidoreductase oxaloacetate decarboxylating Other names in common use include malic enzyme pyruvic malic carboxylase NAD specific malic enzyme NAD malic enzyme and NAD linked malic enzyme This enzyme participates in pyruvate metabolism Structural studies EditAs of late 2007 6 structures have been solved for this class of enzymes with PDB accession codes 1DO8 1EFK 1EFL 1GZ3 1LLQ 1O0S 1PJ2 1PJ3 1PJ4 1PJL 1QR6 1WW8 and 2DVM See also EditME2 gene References EditKaufman S Korkes S Del Campillo A 1951 Biosynthesis of dicarboxylic acids by carbon dioxide fixation V Further studies of the malic enzyme of Lactobacillus arabinosus J Biol Chem 192 301 312 PMID 14917678 Portal Biology Retrieved from https en wikipedia org w index php title Malate dehydrogenase oxaloacetate decarboxylating amp oldid 1172352637, wikipedia, wiki, book, books, library,
