Magaldrat was first synthesized by the German chemist Gunther Hallmann and patented on February 2, 1960, by Byk Gulden Lomberg Chemische Fabrik (Germany).[1] In 1983, the active substance was registered as the original drug Riopan.[2]
Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly by gastric acid into Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[3]
^US patent 2923660, Hallmann G, "Process for the preparation of magnesium aluminate hydrate, and therapeutic agents so produced", issued 1960-02-02, assigned to Byk Gulden Lomberg Chem. Fab.
^Fachinfo Riopan Magen Tabletten, Stand Dezember 2014.
^Laurence BL. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed.
magaldrate, common, antacid, drug, that, used, treatment, duodenal, gastric, ulcers, esophagitis, from, gastroesophageal, reflux, displaystyle, clinical, dataahfs, drugs, commicromedex, detailed, consumer, informationmedlineplusa682683pregnancycategorycroutes,. Magaldrate INN is a common antacid drug that is used for the treatment of duodenal and gastric ulcers esophagitis from gastroesophageal reflux Magaldrate Al3 Mg2 2 HO 7 H2O displaystyle ce Al 3 Mg 2 2 HO 7 H2O Clinical dataAHFS Drugs comMicromedex Detailed Consumer InformationMedlinePlusa682683PregnancycategoryCRoutes ofadministrationOralATC codeA02AD02 WHO A02AF01 WHO combination with antiflatulents Legal statusLegal statusIn general Over the counter OTC Pharmacokinetic dataBioavailabilityNegligibleMetabolismNilExcretionFecal and renalIdentifiersIUPAC name Magnesium aluminate monohydrateCAS Number74978 16 8 YPubChem CID6336542ChemSpider4891688 YUNII6V88E24N5TCompTox Dashboard EPA DTXSID00157184ECHA InfoCard100 115 465Chemical and physical dataFormulaAlMg2 OH 7 H2OMolar mass212 66 g molInChI InChI 1S Al Mg 2H2O h 2 1H2 p 1 YKey SXSTVPXRZQQBKQ UHFFFAOYSA M Y verify Contents 1 Development 2 Available forms 3 Pharmacology 4 Interactions and adverse reactions 5 ReferencesDevelopment editMagaldrat was first synthesized by the German chemist Gunther Hallmann and patented on February 2 1960 by Byk Gulden Lomberg Chemische Fabrik Germany 1 In 1983 the active substance was registered as the original drug Riopan 2 Available forms editMagaldrate is available in the form of oral suspension or tablets Pharmacology editMagaldrate is a hydroxymagnesium aluminate complex that is converted rapidly by gastric acid into Mg OH 2 and Al OH 3 which are absorbed poorly and thus provide a sustained antacid effect 3 Interactions and adverse reactions editMagaldrate may negatively influence drugs like tetracyclines benzodiazepines and indomethacin High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence In some cases it can alter the functionality of the gastrointestinal tract occasionally provoking constipation or diarrhea References editThis article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Magaldrate news newspapers books scholar JSTOR September 2014 Learn how and when to remove this template message US patent 2923660 Hallmann G Process for the preparation of magnesium aluminate hydrate and therapeutic agents so produced issued 1960 02 02 assigned to Byk Gulden Lomberg Chem Fab Fachinfo Riopan Magen Tabletten Stand Dezember 2014 Laurence BL Goodman amp Gilman s The Pharmacological Basis of Therapeutics 12th ed nbsp This drug article relating to the gastrointestinal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Magaldrate amp oldid 1192769337, wikipedia, wiki, book, books, library,
