MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA. It is believed to be involved in skeletal muscle and glucose metabolism. It is upregulated in response to exercise, and is considered an exercise mimetic.[1][2]
MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.[5]
Referencesedit
^Lee, Changhan; Kim, Kyung Hwa; Cohen, Pinchas (1 November 2016). "MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism". Free Radical Biology and Medicine. 100: 182–187. doi:10.1016/j.freeradbiomed.2016.05.015. ISSN 0891-5849. PMC5116416. PMID 27216708.
^Dieli-Conwright, Christina M.; Sami, Nathalie; Norris, Mary K.; Wan, Junxiang; Kumagai, Hiroshi; Kim, Su-Jeong; Cohen, Pinchas (19 August 2021). "Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors". Scientific Reports. 11 (1): 16916. Bibcode:2021NatSR..1116916D. doi:10.1038/s41598-021-96419-z. ISSN 2045-2322. PMC8376922. PMID 34413391.
^Kumagai, Hiroshi; Kim, Su-Jeong; Miller, Brendan; Natsume, Toshiharu; Lee, Shin Hyung; Sato, Ayaka; Ramirez, Ricardo; Wan, Junxiang; Mehta, Hemal H; Yen, Kelvin; Cohen, Pinchas (May 2023). "Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein MOTS-c". Physiology. 38 (S1). doi:10.1152/physiol.2023.38.S1.5725846. ISSN 1548-9213. S2CID 258979715.
^Wan, Wei; Zhang, Lieliang; Lin, Yue; Rao, Xiuqing; Wang, Xifeng; Hua, Fuzhou; Ying, Jun (2023). "Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging". Journal of Translational Medicine. 21 (1): 36. doi:10.1186/s12967-023-03885-2. PMC9854231. PMID 36670507.
^"Explanation of Key Changes on the 2024 WADA Prohibited List". 13 October 2023. Retrieved 6 December 2023.
January 01, 1970
mots, mitochondrial, open, reading, frame, rrna, peptide, encoded, mitochondrial, believed, involved, skeletal, muscle, glucose, metabolism, upregulated, response, exercise, considered, exercise, mimetic, binds, casein, kinase, society, culture, editresearcher. MOTS c mitochondrial open reading frame of the 12S rRNA c is a peptide encoded in mitochondrial DNA It is believed to be involved in skeletal muscle and glucose metabolism It is upregulated in response to exercise and is considered an exercise mimetic 1 2 MOTS c binds to casein kinase 2 3 Society and culture editResearchers discovered MOTS c in 2015 4 MOTS c is not approved to treat any medical condition and is banned by the World Anti Doping Agency explicitly beginning in 2024 5 References edit Lee Changhan Kim Kyung Hwa Cohen Pinchas 1 November 2016 MOTS c A novel mitochondrial derived peptide regulating muscle and fat metabolism Free Radical Biology and Medicine 100 182 187 doi 10 1016 j freeradbiomed 2016 05 015 ISSN 0891 5849 PMC 5116416 PMID 27216708 Dieli Conwright Christina M Sami Nathalie Norris Mary K Wan Junxiang Kumagai Hiroshi Kim Su Jeong Cohen Pinchas 19 August 2021 Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS c in Hispanic and Non Hispanic White breast cancer survivors Scientific Reports 11 1 16916 Bibcode 2021NatSR 1116916D doi 10 1038 s41598 021 96419 z ISSN 2045 2322 PMC 8376922 PMID 34413391 Kumagai Hiroshi Kim Su Jeong Miller Brendan Natsume Toshiharu Lee Shin Hyung Sato Ayaka Ramirez Ricardo Wan Junxiang Mehta Hemal H Yen Kelvin Cohen Pinchas May 2023 Casein kinase 2 is a direct binding partner and a functional target of the exercise mimetic microprotein MOTS c Physiology 38 S1 doi 10 1152 physiol 2023 38 S1 5725846 ISSN 1548 9213 S2CID 258979715 Wan Wei Zhang Lieliang Lin Yue Rao Xiuqing Wang Xifeng Hua Fuzhou Ying Jun 2023 Mitochondria derived peptide MOTS c effects and mechanisms related to stress metabolism and aging Journal of Translational Medicine 21 1 36 doi 10 1186 s12967 023 03885 2 PMC 9854231 PMID 36670507 Explanation of Key Changes on the 2024 WADA Prohibited List 13 October 2023 Retrieved 6 December 2023 Retrieved from https en wikipedia org w index php title MOTS c amp oldid 1221498333, wikipedia, wiki, book, books, library,
