microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000221792 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
mir1282, microrna, 1282, protein, that, humans, encoded, gene, identifiersaliases, mirn1282, 1282, microrna, 1282external, idsgenecards, gene, location, human, chromosome, human, band15q15, 3start43, end43, expression, patternbgeehumanmouse, ortholog, expresse. MicroRNA 1282 is a protein that in humans is encoded by the MIR1282 gene 3 MIR1282IdentifiersAliasesMIR1282 MIRN1282 hsa mir 1282 microRNA 1282External IDsGeneCards MIR1282Gene location Human Chr Chromosome 15 human 1 Band15q15 3Start43 793 659 bp 1 End43 793 759 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervegastrocnemius muscleblooddorsolateral prefrontal cortexAchilles tendonheartupper lobe of left lungleft ventricleleft lobe of thyroid glandputamenn aMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez100302254n aEnsemblENSG00000221792n aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC Chr 15 43 79 43 79 Mbn aPubMed search 2 n aWikidataView Edit HumanFunction editmicroRNAs miRNAs are short 20 24 nt non coding RNAs that are involved in post transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts pri miRNAs that can be either protein coding or non coding The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nt stem loop precursor miRNA pre miRNA which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star miRNA products The mature miRNA is incorporated into a RNA induced silencing complex RISC which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA The RefSeq represents the predicted microRNA stem loop provided by RefSeq Sep 2009 References edit a b c GRCh38 Ensembl release 89 ENSG00000221792 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene MicroRNA 1282 Retrieved 2018 04 20 Further reading editThis article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 15 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MIR1282 amp oldid 1177907079, wikipedia, wiki, book, books, library,
