Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of malignanttumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue (or in cells that display epithelial characteristics) that bear microscopic resemblance to lymphoepithelioma (nasopharyngeal carcinoma).
Lymphoepithelioma-like carcinoma
Low magnification micrograph of a lymphoepithelioma-like carcinoma showing the characteristic squamoid nests in association with clusters of lymphocytes. H&E stain.
There is considerable variation in the classification of LELC—while it is perhaps most commonly considered a subtype of squamous cell carcinoma, it can also be classified as a form of large cell carcinoma (i.e. when occurring in the lung),[1] and can be considered as a separate, unique entity.[2]
In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator.[4]
^Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. (2004). (PDF). World Health Organization Classification of Tumours. Lyon: IARC Press. ISBN92-832-2418-3. Archived from the original (PDF) on 23 August 2009. Retrieved 27 March 2010.
^Skinner, NE.; Horowitz, RI.; Majmudar, B. (Oct 2000). "Lymphoepithelioma-like carcinoma of the uterine cervix". South Med J. 93 (10): 1024–7. doi:10.1097/00007611-200010000-00017. PMID 11147469. S2CID 30613068.
^Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder—diagnostic and clinical implications". Nat Clin Pract Urol. 4 (3): 167–71. doi:10.1038/ncpuro0725. PMID 17347662. S2CID 1506647.
^Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein–Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction". American Journal of Clinical Pathology. 103 (4): 449–52. doi:10.1093/ajcp/103.4.449. PMID 7726142.
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lymphoepithelioma, like, carcinoma, lelc, medical, term, referring, histological, variant, malignant, tumor, arising, from, uncontrolled, mitosis, transformed, cells, originating, epithelial, tissue, cells, that, display, epithelial, characteristics, that, bea. Lymphoepithelioma like carcinoma LELC is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue or in cells that display epithelial characteristics that bear microscopic resemblance to lymphoepithelioma nasopharyngeal carcinoma Lymphoepithelioma like carcinomaLow magnification micrograph of a lymphoepithelioma like carcinoma showing the characteristic squamoid nests in association with clusters of lymphocytes H amp E stain SpecialtyOncology There is considerable variation in the classification of LELC while it is perhaps most commonly considered a subtype of squamous cell carcinoma it can also be classified as a form of large cell carcinoma i e when occurring in the lung 1 and can be considered as a separate unique entity 2 In most anatomical sites many cases are associated with the Epstein Barr virus 3 In the breast the macroscopic microscopic epidemiologic and prognostic features of LELC are very similar to medullary carcinoma EBV status is one differentiator 4 See also editNasopharyngeal carcinoma LymphoepitheliomaReferences edit Travis William D Brambilla Elisabeth Muller Hermelink H Konrad et al eds 2004 Pathology and Genetics of Tumours of the Lung Pleura Thymus and Heart PDF World Health Organization Classification of Tumours Lyon IARC Press ISBN 92 832 2418 3 Archived from the original PDF on 23 August 2009 Retrieved 27 March 2010 Skinner NE Horowitz RI Majmudar B Oct 2000 Lymphoepithelioma like carcinoma of the uterine cervix South Med J 93 10 1024 7 doi 10 1097 00007611 200010000 00017 PMID 11147469 S2CID 30613068 Mayer EK Beckley I Winkler MH Mar 2007 Lymphoepithelioma like carcinoma of the urinary bladder diagnostic and clinical implications Nat Clin Pract Urol 4 3 167 71 doi 10 1038 ncpuro0725 PMID 17347662 S2CID 1506647 Lespagnard L Cochaux P Larsimont D Degeyter M Velu T Heimann R Apr 1995 Absence of Epstein Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping in situ hybridization and polymerase chain reaction American Journal of Clinical Pathology 103 4 449 52 doi 10 1093 ajcp 103 4 449 PMID 7726142 External links edit nbsp This oncology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Lymphoepithelioma like carcinoma amp oldid 1183288996, wikipedia, wiki, book, books, library,
