fbpx
Wikipedia

Lorenzo's oil

March 05, 2023

For the film, see Lorenzo's Oil.

Lorenzo’s oil is liquid solution, made of 4 parts glycerol trioleate and 1 part glycerol trierucate, which are the triacylglycerol forms of oleic acid and erucic acid.[1] It is prepared from olive oil and rapeseed oil.[2] It is used in the investigational treatment of asymptomatic patients with adrenoleukodystrophy (ALD), a nervous system disorder.

Bottle of Lorenzo's oil
Erucic acid
Oleic acid
The two component oils

The development of the oil was led by Augusto and Michaela Odone after their son Lorenzo was diagnosed with the disease in 1984, at the age of five. Lorenzo was predicted to die within a few years. His parents sought experimental treatment options, and the initial formulation of the oil was developed by retired British scientist Don Suddaby (formerly of Croda International).[3] Suddaby and his colleague, Keith Coupland, received U.S. Patent No. 5,331,009[4] for the oil. The royalties received by Augusto were paid to The Myelin Project which he and Michaela founded to further research treatments for ALD and similar disorders.[citation needed] The Odones and their invention obtained widespread publicity in 1992 because of the film Lorenzo's Oil.

Research on the effectiveness of Lorenzo's Oil has seen mixed results, with possible benefit for asymptomatic ALD patients but of unpredictable or no benefit to those with symptoms, suggesting its possible role as a preventative measure in families identified as ALD dominant. Lorenzo Odone died on May 30, 2008, at the age of 30; he was bedridden with paralysis and died from aspiration pneumonia, likely caused by having inhaled food.[5][6]

Treatment costs

Lorenzo's oil costs approximately $400 USD for a month's treatment.[7]

Proposed mechanism of action

The mixture of fatty acids purportedly reduces the levels of very long chain fatty acids (VLCFAs), which are elevated in ALD. It does so by competitively inhibiting the enzyme that forms VLCFAs.[8]

Effectiveness

Main article: Adrenoleukodystrophy § Treatment

Lorenzo's oil, in combination with a diet low in VLCFA, has been investigated for its possible effects on the progression of ALD. Clinical results have been mixed and the use of Lorenzo's oil has been controversial due to uncertainties regarding its clinical efficacy and the clinical indications for its use.[9]

Hugo Moser played a prominent role in both the treatment of Lorenzo Odone and the scientific evaluation of Lorenzo's oil. In 2005, Moser published a controlled study concluding that Lorenzo's oil does not alter the course of the illness in symptomatic patients, but asymptomatic patients had a reduced risk of developing ALD while on the dietary therapy.[10] Moser appraised Lorenzo's oil again in a 2007 report.[11]

Moser's findings, that Lorenzo's oil did not help symptomatic ALD patients, are consistent with prior studies published in 2003[12] and 1999.[9][13]

A study by Poulos published in 1994 found that Lorenzo's oil is of limited value in correcting the accumulation of saturated VLCFAs in the brain of patients with ALD.[14] Comparative autopsies showed that treatment enriched erucic acid in plasma and tissues, but not in the brain.[15]

Side effects

The oil has been shown to cause a lowered platelet count,[16] which can lead to thrombocytopenia and lymphopenia.[17]: 646–657 

There are no reports of toxicity from dietary consumption of erucic acid.[17][18][19]

Current state

Dietary manipulation using Lorenzo's oil has been shown to lower blood levels of very long chain fatty acids, but it is ineffective in symptomatic ALD. Moser's 2005 study has found "strongly suggestive, albeit not fully definitive, evidence of a preventive effect" of Lorenzo's oil on the onset of symptoms when used by asymptomatic patients.[10]

References

  1. ^ . www.lowproteinconnect.com. 20 October 2020. Archived from the original on 27 June 2020. Retrieved 13 July 2022. {{cite web}}: Cite uses generic title (help)
  2. ^ Shankar Vedantam. "A Real-Life Sequel to 'Lorenzo's Oil' - washingtonpost.com". Washington Post 2007-01-28. pp. A01. Retrieved 2007-12-10.
  3. ^ "Lorenzo Odone". 1 June 2008 – via www.telegraph.co.uk.
  4. ^ U.S. Patent 5,331,009: Pharmaceutical compositions for treating adrenoleukodystrophy. Issued July 19, 1994.
  5. ^ "Lorenzo's Oil boy is dead at 30". BBC News. 31 May 2008. Retrieved 2008-06-02.
  6. ^ . CNN. Associated Press. 2008-05-30. Archived from the original on July 17, 2008. Retrieved 2008-07-12.
  7. ^ "Lorenzo's Oil - The Oil". The Myelin Project. Retrieved 3 November 2012.
  8. ^ . www.myelin.org. Archived from the original on 4 November 2013. Retrieved 17 January 2022.{{cite web}}: CS1 maint: archived copy as title (link)
  9. ^ a b Berger J, Pujol A, Aubourg P, Forss-Petter S (July 2010). "Current and Future Pharmacological Treatment Strategies in X-Linked Adrenoleukodystrophy". Brain Pathol. 20 (4): 845–56. doi:10.1111/j.1750-3639.2010.00393.x. PMC 2967711. PMID 20626746.
  10. ^ a b Moser HW, Raymond GV, Lu SE, Muenz LR, Moser AB, Xu J, Jones RO, Loes DJ, Melhem ER, Dubey P, Bezman L, Brereton NH, Odone A (July 2005). "Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's Oil". Archives of Neurology. 62 (7): 1073–80. doi:10.1001/archneur.62.7.1073. PMID 16009761.
  11. ^ Moser HW, Moser AB, Hollandsworth K, Brereton NH, Raymond GV (September 2007). ""Lorenzo's oil" therapy for X-linked adrenoleukodystrophy: rationale and current assessment of efficacy". J. Mol. Neurosci. 33 (1): 105–13. doi:10.1007/s12031-007-0041-4. PMID 17901554. S2CID 21333247.
  12. ^ Aubourg P, Adamsbaum C, Lavallard-Rousseau MC, Rocchiccioli F, Cartier N, Jambaqué I, Jakobezak C, Lemaitre A, Boureau F, Wolf C (September 1993). "A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy". N. Engl. J. Med. 329 (11): 745–52. doi:10.1056/NEJM199309093291101. PMID 8350883.
  13. ^ van Geel BM, Assies J, Haverkort EB, Koelman JH, Verbeeten B, Wanders RJ, Barth PG (September 1999). "Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil"". J. Neurol. Neurosurg. Psychiatry. 67 (3): 290–9. doi:10.1136/jnnp.67.3.290. PMC 1736534. PMID 10449548.
  14. ^ Poulos A, Gibson R, Sharp P, Beckman K, Grattan-Smith P (1994). "Very long chain fatty acids in X-linked adrenoleukodystrophy brain after treatment with Lorenzo's oil". Ann. Neurol. 36 (5): 741–6. doi:10.1002/ana.410360509. PMID 7979219. S2CID 41340913.
  15. ^ Magnhild Rasmussen; Ann B. Moser; Janet Borel; Surinder Khangoora; Hugo W. Moser (Aug 1994). "Brain, liver, and adipose tissue erucic and very long chain fatty acid levels in adrenoleukodystrophy patients treated with glyceryl trierucate and trioleate oils (Lorenzo's Oil)". Neurochemical Research. Springer Netherlands. 19 (8): 1073–1082. doi:10.1007/BF00968719. PMID 7800117. S2CID 11658824.
  16. ^ Crowther MA, Barr RD, Kelton J, Whelan D, Greenwald M (February 1995). "Profound thrombocytopenia complicating dietary erucic acid therapy for adrenoleukodystrophy". American Journal of Hematology. 48 (2): 132–3. doi:10.1002/ajh.2830480217. PMID 7847331. S2CID 29556389.
  17. ^ a b Luger CL et al. Food Safety and Foodborne Toxicants. Chapter 14 in Hayes' Principles and Methods of Toxicology, Sixth Edition. Eds A. Wallace Hayes, Claire L. Kruger. CRC Press, 2014 ISBN 9781842145371. Quote: "In humans. however. although the long-term use of Lorenzo's oil (oleic acid and erucic acid) in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy leads to thrombocytopenia and lymphopenia (Unkrig et al. 1994), adverse effects from dietary consumption of erucic acid have not been reported."
  18. ^ Food Standards Australia New Zealand (June 2003) Erucic acid in food 2008-12-03 at the Wayback Machine : A Toxicological Review and Risk Assessment . Technical report series No. 21; Page 4 paragraph 1; ISBN 0-642-34526-0, ISSN 1448-3017
  19. ^ "Food Standards Agency - Agency issues warning on erucic acid". 2 September 2004. Retrieved 2007-11-02.

External links

  • The Myelin Project (international site)
  • Lorenzo and His Parents (official site of book)

March 05, 2023
lorenzo, film, lorenzo, lorenzo, liquid, solution, made, parts, glycerol, trioleate, part, glycerol, trierucate, which, triacylglycerol, forms, oleic, acid, erucic, acid, prepared, from, olive, rapeseed, used, investigational, treatment, asymptomatic, patients. For the film see Lorenzo s Oil Lorenzo s oil is liquid solution made of 4 parts glycerol trioleate and 1 part glycerol trierucate which are the triacylglycerol forms of oleic acid and erucic acid 1 It is prepared from olive oil and rapeseed oil 2 It is used in the investigational treatment of asymptomatic patients with adrenoleukodystrophy ALD a nervous system disorder Bottle of Lorenzo s oil Erucic acidOleic acidThe two component oils The development of the oil was led by Augusto and Michaela Odone after their son Lorenzo was diagnosed with the disease in 1984 at the age of five Lorenzo was predicted to die within a few years His parents sought experimental treatment options and the initial formulation of the oil was developed by retired British scientist Don Suddaby formerly of Croda International 3 Suddaby and his colleague Keith Coupland received U S Patent No 5 331 009 4 for the oil The royalties received by Augusto were paid to The Myelin Project which he and Michaela founded to further research treatments for ALD and similar disorders citation needed The Odones and their invention obtained widespread publicity in 1992 because of the film Lorenzo s Oil Research on the effectiveness of Lorenzo s Oil has seen mixed results with possible benefit for asymptomatic ALD patients but of unpredictable or no benefit to those with symptoms suggesting its possible role as a preventative measure in families identified as ALD dominant Lorenzo Odone died on May 30 2008 at the age of 30 he was bedridden with paralysis and died from aspiration pneumonia likely caused by having inhaled food 5 6 Contents 1 Treatment costs 2 Proposed mechanism of action 3 Effectiveness 4 Side effects 5 Current state 6 References 7 External linksTreatment costs EditLorenzo s oil costs approximately 400 USD for a month s treatment 7 Proposed mechanism of action EditThe mixture of fatty acids purportedly reduces the levels of very long chain fatty acids VLCFAs which are elevated in ALD It does so by competitively inhibiting the enzyme that forms VLCFAs 8 Effectiveness EditMain article Adrenoleukodystrophy Treatment Lorenzo s oil in combination with a diet low in VLCFA has been investigated for its possible effects on the progression of ALD Clinical results have been mixed and the use of Lorenzo s oil has been controversial due to uncertainties regarding its clinical efficacy and the clinical indications for its use 9 Hugo Moser played a prominent role in both the treatment of Lorenzo Odone and the scientific evaluation of Lorenzo s oil In 2005 Moser published a controlled study concluding that Lorenzo s oil does not alter the course of the illness in symptomatic patients but asymptomatic patients had a reduced risk of developing ALD while on the dietary therapy 10 Moser appraised Lorenzo s oil again in a 2007 report 11 Moser s findings that Lorenzo s oil did not help symptomatic ALD patients are consistent with prior studies published in 2003 12 and 1999 9 13 A study by Poulos published in 1994 found that Lorenzo s oil is of limited value in correcting the accumulation of saturated VLCFAs in the brain of patients with ALD 14 Comparative autopsies showed that treatment enriched erucic acid in plasma and tissues but not in the brain 15 Side effects EditThe oil has been shown to cause a lowered platelet count 16 which can lead to thrombocytopenia and lymphopenia 17 646 657 There are no reports of toxicity from dietary consumption of erucic acid 17 18 19 Current state EditDietary manipulation using Lorenzo s oil has been shown to lower blood levels of very long chain fatty acids but it is ineffective in symptomatic ALD Moser s 2005 study has found strongly suggestive albeit not fully definitive evidence of a preventive effect of Lorenzo s oil on the onset of symptoms when used by asymptomatic patients 10 References Edit Page Not Found www lowproteinconnect com 20 October 2020 Archived from the original on 27 June 2020 Retrieved 13 July 2022 a href Template Cite web html title Template Cite web cite web a Cite uses generic title help Shankar Vedantam A Real Life Sequel to Lorenzo s Oil washingtonpost com Washington Post 2007 01 28 pp A01 Retrieved 2007 12 10 Lorenzo Odone 1 June 2008 via www telegraph co uk U S Patent 5 331 009 Pharmaceutical compositions for treating adrenoleukodystrophy Issued July 19 1994 Lorenzo s Oil boy is dead at 30 BBC News 31 May 2008 Retrieved 2008 06 02 Subject of Lorenzo s Oil dies at 30 CNN Associated Press 2008 05 30 Archived from the original on July 17 2008 Retrieved 2008 07 12 Lorenzo s Oil The Oil The Myelin Project Retrieved 3 November 2012 Archived copy www myelin org Archived from the original on 4 November 2013 Retrieved 17 January 2022 a href Template Cite web html title Template Cite web cite web a CS1 maint archived copy as title link a b Berger J Pujol A Aubourg P Forss Petter S July 2010 Current and Future Pharmacological Treatment Strategies in X Linked Adrenoleukodystrophy Brain Pathol 20 4 845 56 doi 10 1111 j 1750 3639 2010 00393 x PMC 2967711 PMID 20626746 a b Moser HW Raymond GV Lu SE Muenz LR Moser AB Xu J Jones RO Loes DJ Melhem ER Dubey P Bezman L Brereton NH Odone A July 2005 Follow up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo s Oil Archives of Neurology 62 7 1073 80 doi 10 1001 archneur 62 7 1073 PMID 16009761 Moser HW Moser AB Hollandsworth K Brereton NH Raymond GV September 2007 Lorenzo s oil therapy for X linked adrenoleukodystrophy rationale and current assessment of efficacy J Mol Neurosci 33 1 105 13 doi 10 1007 s12031 007 0041 4 PMID 17901554 S2CID 21333247 Aubourg P Adamsbaum C Lavallard Rousseau MC Rocchiccioli F Cartier N Jambaque I Jakobezak C Lemaitre A Boureau F Wolf C September 1993 A two year trial of oleic and erucic acids Lorenzo s oil as treatment for adrenomyeloneuropathy N Engl J Med 329 11 745 52 doi 10 1056 NEJM199309093291101 PMID 8350883 van Geel BM Assies J Haverkort EB Koelman JH Verbeeten B Wanders RJ Barth PG September 1999 Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X linked adrenoleukodystrophy despite treatment with Lorenzo s oil J Neurol Neurosurg Psychiatry 67 3 290 9 doi 10 1136 jnnp 67 3 290 PMC 1736534 PMID 10449548 Poulos A Gibson R Sharp P Beckman K Grattan Smith P 1994 Very long chain fatty acids in X linked adrenoleukodystrophy brain after treatment with Lorenzo s oil Ann Neurol 36 5 741 6 doi 10 1002 ana 410360509 PMID 7979219 S2CID 41340913 Magnhild Rasmussen Ann B Moser Janet Borel Surinder Khangoora Hugo W Moser Aug 1994 Brain liver and adipose tissue erucic and very long chain fatty acid levels in adrenoleukodystrophy patients treated with glyceryl trierucate and trioleate oils Lorenzo s Oil Neurochemical Research Springer Netherlands 19 8 1073 1082 doi 10 1007 BF00968719 PMID 7800117 S2CID 11658824 Crowther MA Barr RD Kelton J Whelan D Greenwald M February 1995 Profound thrombocytopenia complicating dietary erucic acid therapy for adrenoleukodystrophy American Journal of Hematology 48 2 132 3 doi 10 1002 ajh 2830480217 PMID 7847331 S2CID 29556389 a b Luger CL et al Food Safety and Foodborne Toxicants Chapter 14 in Hayes Principles and Methods of Toxicology Sixth Edition Eds A Wallace Hayes Claire L Kruger CRC Press 2014 ISBN 9781842145371 Quote In humans however although the long term use of Lorenzo s oil oleic acid and erucic acid in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy leads to thrombocytopenia and lymphopenia Unkrig et al 1994 adverse effects from dietary consumption of erucic acid have not been reported Food Standards Australia New Zealand June 2003 Erucic acid in food Archived 2008 12 03 at the Wayback Machine A Toxicological Review and Risk Assessment Technical report series No 21 Page 4 paragraph 1 ISBN 0 642 34526 0 ISSN 1448 3017 Food Standards Agency Agency issues warning on erucic acid 2 September 2004 Retrieved 2007 11 02 External links EditThe Myelin Project international site Lorenzo and His Parents official site of book Retrieved from https en wikipedia org w index php title Lorenzo 27s oil amp oldid 1136420826, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.