This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating). Other names in common use include lithocholate 6beta-monooxygenase, CYP3A10, 6beta-hydroxylase, and cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase.
Referencesedit
Teixeira J, Gil G (1991). "Cloning, expression, and regulation of lithocholic acid 6 beta-hydroxylase". J. Biol. Chem. 266 (31): 21030–6. PMID 1840595.
Chang TK, Teixeira J, Gil G, Waxman DJ. "The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation". Biochem. J. 291: 429–33. PMC1132543. PMID 8484723.
Subramanian A, Wang J, Gil G (1998). "STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase". Nucleic Acids Res. 26 (9): 2173–8. doi:10.1093/nar/26.9.2173. PMC147524. PMID 9547277.
Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72 (1): 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
lithocholate, 6beta, hydroxylase, enzymology, lithocholate, 6beta, hydroxylase, enzyme, that, catalyzes, chemical, reactionidentifiersec, 94databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepd. In enzymology a lithocholate 6beta hydroxylase EC 1 14 13 94 is an enzyme that catalyzes the chemical reactionLithocholate 6beta hydroxylaseIdentifiersEC no 1 14 13 94DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins lithocholate NADPH H O2 displaystyle rightleftharpoons 6beta hydroxylithocholate NADP H2OThe 4 substrates of this enzyme are lithocholate NADPH H and O2 whereas its 3 products are 6beta hydroxylithocholate NADP and H2O This enzyme belongs to the family of oxidoreductases specifically those acting on paired donors with O2 as oxidant and incorporation or reduction of oxygen The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor and incorporation of one atom o oxygen into the other donor The systematic name of this enzyme class is lithocholate NADPH oxygen oxidoreductase 6beta hydroxylating Other names in common use include lithocholate 6beta monooxygenase CYP3A10 6beta hydroxylase and cytochrome P450 3A10 lithocholic acid 6beta hydroxylase References editTeixeira J Gil G 1991 Cloning expression and regulation of lithocholic acid 6 beta hydroxylase J Biol Chem 266 31 21030 6 PMID 1840595 Chang TK Teixeira J Gil G Waxman DJ The lithocholic acid 6 beta hydroxylase cytochrome P 450 CYP 3A10 is an active catalyst of steroid hormone 6 beta hydroxylation Biochem J 291 429 33 PMC 1132543 PMID 8484723 Subramanian A Wang J Gil G 1998 STAT 5 and NF Y are involved in expression and growth hormone mediated sexually dimorphic regulation of cytochrome P450 3A10 lithocholic acid 6beta hydroxylase Nucleic Acids Res 26 9 2173 8 doi 10 1093 nar 26 9 2173 PMC 147524 PMID 9547277 Russell DW 2003 The enzymes regulation and genetics of bile acid synthesis Annu Rev Biochem 72 1 137 74 doi 10 1146 annurev biochem 72 121801 161712 PMID 12543708 Portal nbsp Biology This EC 1 14 13 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Lithocholate 6beta hydroxylase amp oldid 1172392611, wikipedia, wiki, book, books, library,
