In molecular biology, the lipopolysaccharide kinase (Kdo/WaaP) family is a family of lipopolysaccharidekinases that includes lipopolysaccharide core heptose(I) kinase rfaP (encoded by the waaP (rfaP) gene). Lipopolysaccharide core heptose(I) kinase rfaP is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that it is necessary for resistance to hydrophobic and polycationicantimicrobials in E. coli and that it is required for virulence in invasive strains of Salmonella enterica.[1] The family also includes 3-deoxy-D-manno-octulosonic acid kinase (KDO kinase) from Haemophilus influenzae, which phosphorylates Kdo-lipid IV(A), a lipopolysaccharide precursor, and is involved in virulence.[2]
^Yethon JA, Whitfield C (February 2001). "Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability". J. Biol. Chem. 276 (8): 5498–504. doi:10.1074/jbc.M008255200. PMID 11069912.
^White KA, Lin S, Cotter RJ, Raetz CR (1999). "A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence". J Biol Chem. 274 (44): 31391–400. doi:10.1074/jbc.274.44.31391. PMID 10531340.
Further readingedit
Krupa A, Srinivasan N (2002). "Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinases". Protein Sci. 11 (6): 1580–4. doi:10.1110/ps.3560102. PMC2373617. PMID 12021457.
This article incorporates text from the public domain Pfam and InterPro: IPR010440
January 01, 1970
lipopolysaccharide, kinase, waap, family, molecular, biology, lipopolysaccharide, kinase, waap, family, family, lipopolysaccharide, kinases, that, includes, lipopolysaccharide, core, heptose, kinase, rfap, encoded, waap, rfap, gene, lipopolysaccharide, core, h. In molecular biology the lipopolysaccharide kinase Kdo WaaP family is a family of lipopolysaccharide kinases that includes lipopolysaccharide core heptose I kinase rfaP encoded by the waaP rfaP gene Lipopolysaccharide core heptose I kinase rfaP is required for the addition of phosphate to O 4 of the first heptose residue of the lipopolysaccharide LPS inner core region It has previously been shown that it is necessary for resistance to hydrophobic and polycationic antimicrobials in E coli and that it is required for virulence in invasive strains of Salmonella enterica 1 The family also includes 3 deoxy D manno octulosonic acid kinase KDO kinase from Haemophilus influenzae which phosphorylates Kdo lipid IV A a lipopolysaccharide precursor and is involved in virulence 2 KdoIdentifiersSymbolKdoPfamPF06293Pfam clanCL0016InterProIPR010440Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryReferences edit Yethon JA Whitfield C February 2001 Purification and characterization of WaaP from Escherichia coli a lipopolysaccharide kinase essential for outer membrane stability J Biol Chem 276 8 5498 504 doi 10 1074 jbc M008255200 PMID 11069912 White KA Lin S Cotter RJ Raetz CR 1999 A Haemophilus influenzae gene that encodes a membrane bound 3 deoxy D manno octulosonic acid Kdo kinase Possible involvement of kdo phosphorylation in bacterial virulence J Biol Chem 274 44 31391 400 doi 10 1074 jbc 274 44 31391 PMID 10531340 Further reading editKrupa A Srinivasan N 2002 Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram negative bacteria are related to the eukaryotic protein kinases Protein Sci 11 6 1580 4 doi 10 1110 ps 3560102 PMC 2373617 PMID 12021457 This article incorporates text from the public domain Pfam and InterPro IPR010440 Retrieved from https en wikipedia org w index php title Lipopolysaccharide kinase Kdo WaaP family amp oldid 1167249052, wikipedia, wiki, book, books, library,
