This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism.
Structural studiesedit
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2PNO, 2UUH, and 2UUI.
Referencesedit
Bach MK, Brashler JR, Morton DR Jr (1984). "Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase". Arch. Biochem. Biophys. 230 (2): 455–65. doi:10.1016/0003-9861(84)90426-0. PMID 6324687.
Shimizu T (1988). "Enzymes functional in the syntheses of leukotrienes and related compounds". Int. J. Biochem. 20 (7): 661–6. doi:10.1016/0020-711X(88)90160-7. PMID 2846379.
Lam BK, Austen KF (2002). "Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes". Prostaglandins. Other. Lipid. Mediat. 68–69: 511–20. doi:10.1016/S0090-6980(02)00052-7. PMID 12432940.
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ (2002). "Membrane localization and topology of leukotriene C4 synthase". J. Biol. Chem. 277 (32): 28902–8. doi:10.1074/jbc.M203074200. PMID 12023288.
leukotriene, synthase, enzyme, leukotriene, synthase, catalyzes, reactionleukotriene, synthaseleukotriene, synthase, dodecamer, humanidentifiersec, 20cas, 90698, 1databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic. The enzyme leukotriene C4 synthase EC 4 4 1 20 catalyzes the reactionleukotriene C4 synthaseLeukotriene C4 synthase dodecamer HumanIdentifiersEC no 4 4 1 20CAS no 90698 32 1DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins leukotriene C4 displaystyle rightleftharpoons leukotriene A4 glutathioneThis enzyme belongs to the family of lyases specifically the class of carbon sulfur lyases The systematic name of this enzyme class is leukotriene C4 glutathione lyase leukotriene A4 forming Other names in common use include leukotriene C4 synthetase LTC4 synthase LTC4 synthetase leukotriene A4 glutathione S leukotrienyltransferase 7E 9E 11Z 14Z 5S 6R 5 6 epoxyicosa 7 9 11 14 tetraenoate glutathione leukotriene transferase epoxide ring opening 7E 9E 11Z 14Z 5S 6R 6 glutathion S yl 5 hydroxyicosa 7 9 11 14 tetraenoate glutathione lyase epoxide forming This enzyme participates in arachidonic acid metabolism Structural studies editAs of late 2007 3 structures have been solved for this class of enzymes with PDB accession codes 2PNO 2UUH and 2UUI References editBach MK Brashler JR Morton DR Jr 1984 Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells a novel particulate glutathione S transferase Arch Biochem Biophys 230 2 455 65 doi 10 1016 0003 9861 84 90426 0 PMID 6324687 Shimizu T 1988 Enzymes functional in the syntheses of leukotrienes and related compounds Int J Biochem 20 7 661 6 doi 10 1016 0020 711X 88 90160 7 PMID 2846379 Lam BK Austen KF 2002 Leukotriene C4 synthase a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes Prostaglandins Other Lipid Mediat 68 69 511 20 doi 10 1016 S0090 6980 02 00052 7 PMID 12432940 Christmas P Weber BM McKee M Brown D Soberman RJ 2002 Membrane localization and topology of leukotriene C4 synthase J Biol Chem 277 32 28902 8 doi 10 1074 jbc M203074200 PMID 12023288 Portal nbsp Biology nbsp This enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Leukotriene C4 synthase amp oldid 1215905477, wikipedia, wiki, book, books, library,
