LMO3

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.^[3][4][5] LMO3 interacts with the tumor suppressor p53 and regulates its function.^[6] LMO3 is considered to be an oncogene in Neuroblastoma.^[7]

LMO3
Identifiers
Aliases	LMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDs	OMIM: 180386 HomoloGene: 136507 GeneCards: LMO3
Gene location (Human) Chr. Chromosome 12 (human)^[1] Band 12p12.3 Start 16,548,372 bp^[1] End 16,610,594 bp^[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 46 Brodmann area 23 orbitofrontal cortex superior frontal gyrus entorhinal cortex endothelial cell postcentral gyrus optic nerve nucleus accumbens n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component cytoplasm Biological process negative regulation of ERK1 and ERK2 cascade regulation of transcription, DNA-templated positive regulation of fat cell differentiation positive regulation of glucocorticoid receptor signaling pathway transcription, DNA-templated positive regulation of peroxisome proliferator activated receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55885 n/a Ensembl ENSG00000048540 n/a UniProt Q8TAP4 n/a RefSeq (mRNA) NM_001001395 NM_001243609 NM_001243610 NM_001243611 NM_001243612 NM_001243613 NM_018640 n/a RefSeq (protein) NP_001001395 NP_001230538 NP_001230539 NP_001230540 NP_001230541 NP_001230542 NP_061110 n/a Location (UCSC) Chr 12: 16.55 – 16.61 Mb n/a PubMed search ^[2] n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000048540 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
4. Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.
5. EntrezGene 55885
6. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
7. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading

• Friedel S, Saar K, Sauer S, Dempfle A, Walitza S, Renner T, Romanos M, Freitag C, et al. (October 2007). "Association and linkage of allelic variants of the dopamine transporter gene in ADHD". Molecular Psychiatry. 12 (10): 923–33. doi:10.1038/sj.mp.4001986. PMID 17579611.
• Davis C, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Kennedy JL (October 2007). "Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorder". Neuropsychopharmacology. 32 (10): 2199–206. doi:10.1038/sj.npp.1301348. PMID 17314918.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, et al. (June 2005). "LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma". Cancer Research. 65 (11): 4587–97. doi:10.1158/0008-5472.CAN-04-4630. PMID 15930276.
• Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, et al. (August 1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development". Journal of Molecular Biology. 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID 1507224.