This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing). Other names in common use include dihydroxyisovalerate dehydrogenase (isomerizing), acetohydroxy acid isomeroreductase, ketol acid reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, 2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid reductoisomerase, acetolactate reductoisomerase, dihydroxyisovalerate (isomerizing) dehydrogenase, isomeroreductase, and reductoisomerase. This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coa biosynthesis.
Structural studiesedit
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1NP3, 1QMG, 1YRL, and 1YVE.
Referencesedit
Arfin SM, Umbarger HE (1969). "Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium". J. Biol. Chem. 244 (5): 1118–27. PMID 4388025.
Hill RK, Sawada S, Arfin SM (1979). "Stereochemistry of valine and isoleucine biosynthesis. IV Synthesis, configuration, and enzymatic specificity of alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate". Bioorg. Chem. 8 (2): 175–189. doi:10.1016/0045-2068(79)90003-8.
Kiritani K, Narise S, Wagner RP (1966). "The reductoisomerase of Neurospora crassa". J. Biol. Chem. 241: 2047–2051.
Satyanarayana T, Radhakrishnan AN (1965). "Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of Phaseolus radiatus". Biochim. Biophys. Acta. 110 (2): 380–8. doi:10.1016/s0926-6593(65)80045-5. PMID 5866387.
ketol, acid, reductoisomerase, enzymology, ketol, acid, reductoisomerase, enzyme, that, catalyzes, chemical, reactionketol, acid, reductoisomerase, tetramer, alicyclobacillus, acidocaldariusidentifiersec, 86cas, 9075, 9databasesintenzintenz, viewbrendabrenda, . In enzymology a ketol acid reductoisomerase EC 1 1 1 86 is an enzyme that catalyzes the chemical reactionketol acid reductoisomeraseKetol acid reductoisomerase tetramer Alicyclobacillus acidocaldariusIdentifiersEC no 1 1 1 86CAS no 9075 02 9DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins R 2 3 dihydroxy 3 methylbutanoate NADP displaystyle rightleftharpoons S 2 hydroxy 2 methyl 3 oxobutanoate NADPH H Thus the two substrates of this enzyme are R 2 3 dihydroxy 3 methylbutanoate and NADP whereas its 3 products are S 2 hydroxy 2 methyl 3 oxobutanoate NADPH and H This enzyme belongs to the family of oxidoreductases specifically those acting on the CH OH group of donor with NAD or NADP as acceptor The systematic name of this enzyme class is R 2 3 dihydroxy 3 methylbutanoate NADP oxidoreductase isomerizing Other names in common use include dihydroxyisovalerate dehydrogenase isomerizing acetohydroxy acid isomeroreductase ketol acid reductoisomerase alpha keto beta hydroxylacyl reductoisomerase 2 hydroxy 3 keto acid reductoisomerase acetohydroxy acid reductoisomerase acetolactate reductoisomerase dihydroxyisovalerate isomerizing dehydrogenase isomeroreductase and reductoisomerase This enzyme participates in valine leucine and isoleucine biosynthesis and pantothenate and coa biosynthesis Structural studies editAs of late 2007 4 structures have been solved for this class of enzymes with PDB accession codes 1NP3 1QMG 1YRL and 1YVE References editArfin SM Umbarger HE 1969 Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium J Biol Chem 244 5 1118 27 PMID 4388025 Hill RK Sawada S Arfin SM 1979 Stereochemistry of valine and isoleucine biosynthesis IV Synthesis configuration and enzymatic specificity of alpha acetolactate and alpha aceto alpha hydroxybutyrate Bioorg Chem 8 2 175 189 doi 10 1016 0045 2068 79 90003 8 Kiritani K Narise S Wagner RP 1966 The reductoisomerase of Neurospora crassa J Biol Chem 241 2047 2051 Satyanarayana T Radhakrishnan AN 1965 Biosynthesis of valine and isoleucine in plants 3 Reductoisomerase of Phaseolus radiatus Biochim Biophys Acta 110 2 380 8 doi 10 1016 s0926 6593 65 80045 5 PMID 5866387 Portal nbsp Biology This EC 1 1 1 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Ketol acid reductoisomerase amp oldid 1172351100, wikipedia, wiki, book, books, library,
