Kelly A Frazer is a Professor of Pediatrics in the Medical School at the University of California, San Diego, Chief of the Division of Genome Information Sciences[1] and Director of the Institute for Genomic Medicine.[2]
Over the past thirty-three years Frazer has researched and discovered insights into the molecular underpinnings of a wide variety of human diseases and complex traits.[3][4] As a postdoctoral fellow she and Edward Rubin pioneered cross-species DNA sequence comparisons between humans and mice resulting in the discovery of evolutionarily conserved non-codingregulatory sequences in the human genome.[5][6] As Vice President of Genome Biology at Perlegen Sciences Frazer worked with David Cox and others to generate the content for the HapMap Phase II project[7] and determined that common structural variants are largely in linkage disequilibrium with common SNPs.[8] She joined UC San Diego as a faculty member in August 2009[9] and has developed novel methods for identifying and functionally characterizing regulatory variants underlying GWAS signals[10][11][12][13] and has contributed to a greater understanding of mutational signatures in cancer.[14][15]
References
^"Home - Division of Genome Information Sciences - UC San Diego Department of Pediatrics".
^Frazer, KA; Murray, SS; Schork, NJ; Topol, EJ (2009-04-10). "Human Genetic Variation and Its Contribution to Complex Traits". Nature Reviews Genetics. 10 (4): 241–251. doi:10.1038/nrg2554. PMID 1929382. S2CID 19987352.
^Frazer, KA (September 2012). "Decoding the human genome". Genome Research. 22 (9): 1599–1601. doi:10.1101/gr.146175.112. PMC3431476. PMID 22955971.
^Loots, G. G.; Locksley, R. M.; Blankespoor, C. M.; Wang, Z. E.; Miller, W.; Rubin, E. M.; Frazer, K. A. (2000-04-07). "Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons". Science. 288 (5463): 136–140. Bibcode:2000Sci...288..136L. doi:10.1126/science.288.5463.136. ISSN 0036-8075. PMID 10753117.
^Frazer, KA; Pachter, L; Poliakov, A; Rubin, EM; Dubchak, I (2004-07-01). "VISTA: computational tools for comparative genomics". Nucleic Acids Research. 32 (Web Server issue): W273–W279. doi:10.1093/nar/gkh458. PMC441596. PMID 15215394.
^Frazer, KA; Ballinger, DG; Cox, DR; Hinds, DA (2007-10-18). "A Second Generation Human Haplotype Map of Over 3.1 Million SNPs". Nature. 449 (7164): 851–861. Bibcode:2007Natur.449..851F. doi:10.1038/nature06258. hdl:2027.42/62863. PMC2689609. PMID 17943122.
^Hinds, DA; Kloek, AP; Jen, M; Chen, X; Frazer, KA (2005-12-04). "Common deletions and SNPs are in linkage disequilibrium in the human genome". Nature Genetics. 38 (1): 82–85. doi:10.1038/ng1695. PMID 16327809. S2CID 24205661.
^"UCSD Announces Chief of Division of Genome Information Sciences in Pediatrics".
^DeBoever, C; Li, H; Jakubosky, D; Benaglio, P; Reyna, J; Olson, KM (2017-04-06). "Large-scale profiling reveals the influence of genetic variation on gene expression in human induced pluripotent stem cells". Cell Stem Cell. 20 (4): 533–546.e7. doi:10.1016/j.stem.2017.03.009. PMC5444918. PMID 28388430.
^Panapoulos, M; D'Antonio, M; Benaglio, P; Williams, R; Hashem, SI (2017-04-11). "iPSCORE: a resource of 222 iPSC lines enabling functional characterization of genetic variation across a variety of cell types". Stem Cell Reports. 8 (4): 1086–1100. doi:10.1016/j.stemcr.2017.03.012. PMC5390244. PMID 28410642.
^Greenwald, WW; Li, H; Benaglio, P; Jakubosky, D; Matsui, H; Schmitt, A (2019-03-05). "Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression". Nature Communications. 10 (1): 1054. Bibcode:2019NatCo..10.1054G. doi:10.1038/s41467-019-08940-5. PMC6401380. PMID 30837461.
^DeBoever, C; Ghia, EM; Shepard, PJ; Rassenti, L; Barrett, CL; Jepsen, K (2015-03-13). "Transcriptome sequencing reveals potential mechanism of cryptic 3'splice site selection in SF3B1-mutated cancers". PLOS Computational Biology. 11 (3): e1004105. Bibcode:2015PLSCB..11E4105D. doi:10.1371/journal.pcbi.1004105. PMC4358997. PMID 25768983.
^D'Antonio, M; Tamayo, P; Mesirov, JP; Frazer, KA (2016-07-19). "Kataegis Expression Signature in Breast Cancer Is Associated With Late Onset, Better Prognosis, and Higher HER2 Levels". Cell Reports. 16 (3): 672–683. doi:10.1016/j.celrep.2016.06.026. PMC4972030. PMID 27373164.
External links
Faculty web page
Frazer Lab
January 29, 2023
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This article relies excessively on references to primary sources Please improve this article by adding secondary or tertiary sources Find sources Kelly A Frazer news newspapers books scholar JSTOR August 2022 Learn how and when to remove this template message Kelly A Frazer is a Professor of Pediatrics in the Medical School at the University of California San Diego Chief of the Division of Genome Information Sciences 1 and Director of the Institute for Genomic Medicine 2 Kelly A FrazerAlma materUniversity of California San FranciscoKnown forHuman Genomics International HapMap Project Functional characterization of non coding regulatory variantsScientific careerInstitutionsUniversity of California San DiegoDoctoral advisorDavid R CoxOther academic advisorsEdward RubinContents 1 Education 2 Research 3 References 4 External linksEducation EditFrazer did her undergraduate studies at the University of California Santa Cruz She then attended the UCSF Medical Center at the University of California San Francisco and received her PhD in 1993 citation needed Research EditOver the past thirty three years Frazer has researched and discovered insights into the molecular underpinnings of a wide variety of human diseases and complex traits 3 4 As a postdoctoral fellow she and Edward Rubin pioneered cross species DNA sequence comparisons between humans and mice resulting in the discovery of evolutionarily conserved non coding regulatory sequences in the human genome 5 6 As Vice President of Genome Biology at Perlegen Sciences Frazer worked with David Cox and others to generate the content for the HapMap Phase II project 7 and determined that common structural variants are largely in linkage disequilibrium with common SNPs 8 She joined UC San Diego as a faculty member in August 2009 9 and has developed novel methods for identifying and functionally characterizing regulatory variants underlying GWAS signals 10 11 12 13 and has contributed to a greater understanding of mutational signatures in cancer 14 15 References Edit Home Division of Genome Information Sciences UC San Diego Department of Pediatrics Home igm ucsd edu Frazer KA Murray SS Schork NJ Topol EJ 2009 04 10 Human Genetic Variation and Its Contribution to Complex Traits Nature Reviews Genetics 10 4 241 251 doi 10 1038 nrg2554 PMID 1929382 S2CID 19987352 Frazer KA September 2012 Decoding the human genome Genome Research 22 9 1599 1601 doi 10 1101 gr 146175 112 PMC 3431476 PMID 22955971 Loots G G Locksley R M Blankespoor C M Wang Z E Miller W Rubin E M Frazer K A 2000 04 07 Identification of a coordinate regulator of interleukins 4 13 and 5 by cross species sequence comparisons Science 288 5463 136 140 Bibcode 2000Sci 288 136L doi 10 1126 science 288 5463 136 ISSN 0036 8075 PMID 10753117 Frazer KA Pachter L Poliakov A Rubin EM Dubchak I 2004 07 01 VISTA computational tools for comparative genomics Nucleic Acids Research 32 Web Server issue W273 W279 doi 10 1093 nar gkh458 PMC 441596 PMID 15215394 Frazer KA Ballinger DG Cox DR Hinds DA 2007 10 18 A Second Generation Human Haplotype Map of Over 3 1 Million SNPs Nature 449 7164 851 861 Bibcode 2007Natur 449 851F doi 10 1038 nature06258 hdl 2027 42 62863 PMC 2689609 PMID 17943122 Hinds DA Kloek AP Jen M Chen X Frazer KA 2005 12 04 Common deletions and SNPs are in linkage disequilibrium in the human genome Nature Genetics 38 1 82 85 doi 10 1038 ng1695 PMID 16327809 S2CID 24205661 UCSD Announces Chief of Division of Genome Information Sciences in Pediatrics Harismendy O Notani D Song X Rahim NG Tanasa B Heintzman N 2011 02 10 9p21 DNA Variants Associated With Coronary Artery Disease Impair Interferon g Signalling Response Nature 470 7333 264 268 Bibcode 2011Natur 470 264H doi 10 1038 nature09753 PMC 3079517 PMID 21307941 DeBoever C Li H Jakubosky D Benaglio P Reyna J Olson KM 2017 04 06 Large scale profiling reveals the influence of genetic variation on gene expression in human induced pluripotent stem cells Cell Stem Cell 20 4 533 546 e7 doi 10 1016 j stem 2017 03 009 PMC 5444918 PMID 28388430 Panapoulos M D Antonio M Benaglio P Williams R Hashem SI 2017 04 11 iPSCORE a resource of 222 iPSC lines enabling functional characterization of genetic variation across a variety of cell types Stem Cell Reports 8 4 1086 1100 doi 10 1016 j stemcr 2017 03 012 PMC 5390244 PMID 28410642 Greenwald WW Li H Benaglio P Jakubosky D Matsui H Schmitt A 2019 03 05 Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression Nature Communications 10 1 1054 Bibcode 2019NatCo 10 1054G doi 10 1038 s41467 019 08940 5 PMC 6401380 PMID 30837461 DeBoever C Ghia EM Shepard PJ Rassenti L Barrett CL Jepsen K 2015 03 13 Transcriptome sequencing reveals potential mechanism of cryptic 3 splice site selection in SF3B1 mutated cancers PLOS Computational Biology 11 3 e1004105 Bibcode 2015PLSCB 11E4105D doi 10 1371 journal pcbi 1004105 PMC 4358997 PMID 25768983 D Antonio M Tamayo P Mesirov JP Frazer KA 2016 07 19 Kataegis Expression Signature in Breast Cancer Is Associated With Late Onset Better Prognosis and Higher HER2 Levels Cell Reports 16 3 672 683 doi 10 1016 j celrep 2016 06 026 PMC 4972030 PMID 27373164 External links EditFaculty web page Frazer Lab Retrieved from https en wikipedia org w index php title Kelly A Frazer amp oldid 1104895873, wikipedia, wiki, book, books, library,
