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John Q. Trojanowski

John Quinn Trojanowski (December 17, 1946 – February 8, 2022) was an American academic research neuroscientist specializing in neurodegeneration. He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration.[1]

Biography edit

John Quinn Trojanowski was born on December 17, 1946, in Bridgeport, Connecticut, as the second of the seven children of Maurice Trojanowski and Margaret (Quinn) Trojanowski.[2] Trojanowski obtained his M.D./Ph.D. in 1976 from Tufts University in Boston. After a medicine internship at Mt. Auburn Hospital and Harvard Medical School, he began pathology/neuropathology training at Massachusetts General Hospital and Harvard Medical School (1977–1979), and completed training at the University of Pennsylvania School of Medicine in 1980 where he was appointed assistant professor of Pathology and Laboratory Medicine on January 1, 1981, and rose to the rank of tenured full professor in 1990.[3]

Trojanowski held major leadership positions at the University of Pennsylvania including: Director of a National Institute of Aging (NIA) Alzheimer's Disease Center (1991–2022), Principal Investigator of a NIA Program Project Grant on Alzheimer's (AD) and Parkinson's (PD) disease (1990–2005), Director of Medical Pathology (1988–2002), Interim Director (2001–2002) and Director (2002–2022) of the Institute on Aging, Co-Director (1992–2022) of the Center for Neurodegenerative Disease Research, Director, National Institute of Neurological Disorders and Stroke (NINDS) Morris K. Udall Parkinson's Disease Research Center of Excellence (2007–2022), the first William Maul Measey–Truman G. Schnabel, Jr., M.D., Professor of Geriatric Medicine and Gerontology (2003–2022) and Co-director of the Marian S. Ware Alzheimer Drug Discovery Program (2004–2022).[3]

For more than fifteen years, Trojanowski conducted research on AD, PD, motor neuron disease, dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD) and other aging related nervous system disorders. Most of his >500 publications focus on the pathobiology of neurodegenerative disorders, especially the role of abnormal protein aggregates (misfolded proteins) in these diseases. The major goal of his research was to translate advances into understanding mechanisms of aging related neurodegenerative diseases into meaningful interventions to treat or prevent these disorders.[3]

Trojanowski died in Philadelphia from complications of chronic spinal cord injuries on February 8, 2022, at the age of 75.[2][4]

Awards edit

Trojanowski received several awards for his research, including:

  • MERIT Award (1986–1994) from the National Institutes of Health (NIH)
  • Metropolitan Life Foundation Promising Investigator Award For Alzheimer's
    Disease Research (1991)
  • Membership in the American Society for Clinical Investigation (1991)
  • Established Investigator Award from the National Alliance for Research on
    Schizophrenia and Depression (now known as the Brain & Behavior Research Foundation) (1994)
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease (1996)
  • Potamkin Prize For Research In Pick's, Alzheimer's And Related Diseases (1998)
  • First Pioneer Award from the Alzheimer's Association (1998–2003)
  • ISI Highly Cited Researcher 2000 (most highly cited neuroscientists for 1981–1999)
  • Stanley Cohen Biomedical Research Award of the University of Pennsylvania (2000)
  • Membership in the Association of American Physicians (2000)
  • 2004 Irving Wright Award of Distinction of the American Federation for
    Aging Research, and the 2005 Rous-Whipple Award of the American Society for
    Investigative Pathology.
  • 2012 John Scott Award[5]
  • Charter Fellow, National Academy of Inventors, Elected 2012
  • J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014
  • Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June 2015
  • The Mayo Clinic Irving S. Cooper Professorship, “New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies”, Mayo Clinic, Rochester, MN, 21 August 2017
  • Alzheimer's Association Lifetime Achievement Award in Alzheimer's Disease Research, AAIC Meeting, Chicago, IL, 24 July 2018[6]

Service edit

  • Elected President of the American Association of Neuropathologists (1997–1998),
    and has been on the editorial board of several neuroscience
    and pathology journals.
  • Dr. Trojanowski was elected to the Institute of Medicine (2002) and he has
    served and continued to serve on local and national aging research committees
    including the NIA Neuroscience, Behavior and Sociology of
    Aging Study Section (1987–1991)
  • National Advisory Council on Aging (NACA) of the NIA (1994–1998)
  • NACA Working Group Chair (1996–1998)
  • Medical and Scientific Advisory Board of the National Alzheimer's Association
    (1994–1997) as well as of the Southeastern Pennsylvania Chapter of the
    Alzheimer's Association (1992–2022)
  • NIA Board of Scientific Counselors (1998–2002)
  • Scientific Advisory Boards of the Paul Beeson Physician Faculty Scholars
    In Aging Award (1998–2002)
  • Alliance for Aging Research (2002–2022) and the Association of
    Frontotemporal Dementia (2003–2022)
  • Program Committee of the World Alzheimer Congress 2000 (1998–2000)
  • Chair of the "Biology of Synuclein and Cortical Lewy Bodies Associated
    with Dementia in AD, LBD, and PD" (July, 2001) and “Genetics of Alzheimer’s Disease
    (March, 2002) workshops organized by NIA and the National Institute on Neurological
    Diseases and Stroke in Bethesda, Maryland, and the Organizing Committee of the 6th
    (Seville, Spain, 2003), 7th (Sorrento, Italy, 2005) and 8th (Salzburg, Austria, 2007)
    International Conferences On Progress In Alzheimer’s And Parkinson’s Disease
    (2001-2009).

Films edit

To help the public understand what is needed to cure and/or prevent disorders like AD, Trojanowski led an effort to prepare two education films, “Shining a Light on Alzheimer’s Disease . . . through Research” and “Taking the Steps to Healthy Brain Aging”, on Alzheimer's disease and healthy brain aging funded by a grant from the Metropolitan Life Foundation Grant that air on PBS.

References edit

  1. ^ "Virginia Lee and John Trojanowski Interview - Special Topic of Alzheimer's Disease - ScienceWatch.com - Clarivate Analytics". archive.sciencewatch.com. Retrieved 2019-02-27.
  2. ^ a b Kolata, Gina (2022-03-01). "John Q. Trojanowski Dies at 75; Changed Understanding of Brain Diseases". The New York Times. ISSN 0362-4331. Retrieved 2022-03-02.
  3. ^ a b c "John Q. Trojanowski, MD, PhD | Institute on Aging | Perelman School of Medicine at the University of Pennsylvania". www.med.upenn.edu. Retrieved 2019-02-27.
  4. ^ "John Q. Trojanowski, 1946–2022". AFTD. 18 February 2022. Retrieved 27 February 2022.
  5. ^ "The John Scott Award Recipients". Eugene Garfield at University of Pennsylvania. Retrieved 28 September 2018.
  6. ^ "Penn Medicine's John Q. Trojanowski Receives Lifetime Achievement Award from Alzheimer's Association – PR News". www.pennmedicine.org. Retrieved 2019-02-27.

External links edit

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this template message John Quinn Trojanowski December 17 1946 February 8 2022 was an American academic research neuroscientist specializing in neurodegeneration He and his partner Virginia Man Yee Lee MBA Ph D are noted for identifying the roles of three proteins in neurodegenerative diseases tau in Alzheimer s disease alpha synuclein in Parkinson s disease and TDP 43 in Amyotrophic Lateral Sclerosis ALS and frontotemporal degeneration 1 Contents 1 Biography 2 Awards 3 Service 4 Films 5 References 6 External linksBiography editJohn Quinn Trojanowski was born on December 17 1946 in Bridgeport Connecticut as the second of the seven children of Maurice Trojanowski and Margaret Quinn Trojanowski 2 Trojanowski obtained his M D Ph D in 1976 from Tufts University in Boston After a medicine internship at Mt Auburn Hospital and Harvard Medical School he began pathology neuropathology training at Massachusetts General Hospital and Harvard Medical School 1977 1979 and completed training at the University of Pennsylvania School of Medicine in 1980 where he was appointed assistant professor of Pathology and Laboratory Medicine on January 1 1981 and rose to the rank of tenured full professor in 1990 3 Trojanowski held major leadership positions at the University of Pennsylvania including Director of a National Institute of Aging NIA Alzheimer s Disease Center 1991 2022 Principal Investigator of a NIA Program Project Grant on Alzheimer s AD and Parkinson s PD disease 1990 2005 Director of Medical Pathology 1988 2002 Interim Director 2001 2002 and Director 2002 2022 of the Institute on Aging Co Director 1992 2022 of the Center for Neurodegenerative Disease Research Director National Institute of Neurological Disorders and Stroke NINDS Morris K Udall Parkinson s Disease Research Center of Excellence 2007 2022 the first William Maul Measey Truman G Schnabel Jr M D Professor of Geriatric Medicine and Gerontology 2003 2022 and Co director of the Marian S Ware Alzheimer Drug Discovery Program 2004 2022 3 For more than fifteen years Trojanowski conducted research on AD PD motor neuron disease dementia with Lewy bodies DLB frontotemporal lobar degeneration FTLD and other aging related nervous system disorders Most of his gt 500 publications focus on the pathobiology of neurodegenerative disorders especially the role of abnormal protein aggregates misfolded proteins in these diseases The major goal of his research was to translate advances into understanding mechanisms of aging related neurodegenerative diseases into meaningful interventions to treat or prevent these disorders 3 Trojanowski died in Philadelphia from complications of chronic spinal cord injuries on February 8 2022 at the age of 75 2 4 Awards editThis article is in list format but may read better as prose You can help by converting this article if appropriate Editing help is available August 2018 Trojanowski received several awards for his research including MERIT Award 1986 1994 from the National Institutes of Health NIH Metropolitan Life Foundation Promising Investigator Award For Alzheimer s Disease Research 1991 Membership in the American Society for Clinical Investigation 1991 Established Investigator Award from the National Alliance for Research on Schizophrenia and Depression now known as the Brain amp Behavior Research Foundation 1994 Metlife Foundation Award for Medical Research in Alzheimer s Disease 1996 Potamkin Prize For Research In Pick s Alzheimer s And Related Diseases 1998 First Pioneer Award from the Alzheimer s Association 1998 2003 ISI Highly Cited Researcher 2000 most highly cited neuroscientists for 1981 1999 Stanley Cohen Biomedical Research Award of the University of Pennsylvania 2000 Membership in the Association of American Physicians 2000 2004 Irving Wright Award of Distinction of the American Federation for Aging Research and the 2005 Rous Whipple Award of the American Society for Investigative Pathology 2012 John Scott Award 5 Charter Fellow National Academy of Inventors Elected 2012 J Allyn Taylor International Prize in Medicine Molecular Basis of Neurological Disorders the Robarts Institute London Ontario Canada 2014 Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists 13 June 2015 The Mayo Clinic Irving S Cooper Professorship New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies Mayo Clinic Rochester MN 21 August 2017 Alzheimer s Association Lifetime Achievement Award in Alzheimer s Disease Research AAIC Meeting Chicago IL 24 July 2018 6 Service editElected President of the American Association of Neuropathologists 1997 1998 and has been on the editorial board of several neuroscience and pathology journals Dr Trojanowski was elected to the Institute of Medicine 2002 and he has served and continued to serve on local and national aging research committees including the NIA Neuroscience Behavior and Sociology of Aging Study Section 1987 1991 National Advisory Council on Aging NACA of the NIA 1994 1998 NACA Working Group Chair 1996 1998 Medical and Scientific Advisory Board of the National Alzheimer s Association 1994 1997 as well as of the Southeastern Pennsylvania Chapter of the Alzheimer s Association 1992 2022 NIA Board of Scientific Counselors 1998 2002 Scientific Advisory Boards of the Paul Beeson Physician Faculty Scholars In Aging Award 1998 2002 Alliance for Aging Research 2002 2022 and the Association of Frontotemporal Dementia 2003 2022 Program Committee of the World Alzheimer Congress 2000 1998 2000 Chair of the Biology of Synuclein and Cortical Lewy Bodies Associated with Dementia in AD LBD and PD July 2001 and Genetics of Alzheimer s Disease March 2002 workshops organized by NIA and the National Institute on Neurological Diseases and Stroke in Bethesda Maryland and the Organizing Committee of the 6th Seville Spain 2003 7th Sorrento Italy 2005 and 8th Salzburg Austria 2007 International Conferences On Progress In Alzheimer s And Parkinson s Disease 2001 2009 Films editTo help the public understand what is needed to cure and or prevent disorders like AD Trojanowski led an effort to prepare two education films Shining a Light on Alzheimer s Disease through Research and Taking the Steps to Healthy Brain Aging on Alzheimer s disease and healthy brain aging funded by a grant from the Metropolitan Life Foundation Grant that air on PBS References edit Virginia Lee and John Trojanowski Interview Special Topic of Alzheimer s Disease ScienceWatch com Clarivate Analytics archive sciencewatch com Retrieved 2019 02 27 a b Kolata Gina 2022 03 01 John Q Trojanowski Dies at 75 Changed Understanding of Brain Diseases The New York Times ISSN 0362 4331 Retrieved 2022 03 02 a b c John Q Trojanowski MD PhD Institute on Aging Perelman School of Medicine at the University of Pennsylvania www med upenn edu Retrieved 2019 02 27 John Q Trojanowski 1946 2022 AFTD 18 February 2022 Retrieved 27 February 2022 The John Scott Award Recipients Eugene Garfield at University of Pennsylvania Retrieved 28 September 2018 Penn Medicine s John Q Trojanowski Receives Lifetime Achievement Award from Alzheimer s Association PR News www pennmedicine org Retrieved 2019 02 27 External links edithttp www med upenn edu aging http www pennadc org http www med upenn edu cndr https web archive org web 20080614133220 http www med upenn edu ins faculty trojanow htm http www pennhealth com Wagform MainPage aspx config provider amp P PP amp ID 2313 http www uphs upenn edu news News Releases july02 PIA html http chronicle com blogs ticker journal hits u of pennsylvania scientists with retraction 2 year ban 94941 John Q Trojanowski publications indexed by Google Scholar Retrieved from https en wikipedia org w index php title John Q Trojanowski amp oldid 1097355047, wikipedia, wiki, book, books, library,

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