James M. Wilson is a biomedical researcher with expertise in gene therapy. Wilson graduated from Albion College (B.A., Chemistry) and the University of Michigan (MD, PhD).[1] He completed residency training in Internal Medicine at the Massachusetts General Hospital followed by a postdoctoral fellowship at the Whitehead Institute.[2]
Wilson serves as the Director of the Gene Therapy Program, Rose H. Weiss Professor and Director of the Orphan Disease Center, and Professor of Medicine and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.[3] Previously, he held the John Herr Musser endowed professorship at the Perelman School of Medicine.[4]
Wilson led a clinical trial that resulted in the death of Jesse Gelsinger. As a result, the government banned him from working on FDA-regulated human clinical trials for five years, which led to a shift in his research focus towards a study of adeno-associated viruses (AAV).[5]
Scientific contributionsEdit
Wilson’s research involves the development of viral-based gene therapies for genetic diseases. A major research focus is the generation of novel vectors for improved transduction efficiencies and regulated expression, as well as the elucidation of host immune responses to viral vectors.[6] His work emphasizes the creation of vectors for in vivo gene therapy concentrating on adeno-associated viruses. This work began with the discovery in his laboratory of a new family of primate AAVs; over 120 new AAV capsids were rescued as latent genomes from primate tissues and studied for their biology and potential as vectors.[7][8] This has led to an enhanced understanding of vector host interactions and a new generation of vectors with substantially improved performance profiles beyond that provided from the original 6 AAV isolates. More recently, Wilson’s laboratory has used AAV to accomplish successful in vivo genome editing.[9][10]
As of 2018, his laboratory’s translational research portfolio included more than 30 orphan disease programs.[11]
ReferencesEdit
^"James M. Wilson | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania". www.med.upenn.edu. Retrieved 2018-09-28.
^"James M. Wilson - Faculty Biosketch". www.med.upenn.edu. Retrieved 2018-09-28.
^"University of Pennsylvania Gene Therapy Program | Our Team". gtp.med.upenn.edu. Retrieved 2018-09-28.
^"John Herr Musser Professorship of Research Medicine | Endowed Professorships | Perelman School of Medicine at the University of Pennsylvania". www.med.upenn.edu.
^Zimmer, Carl (August 13, 2013). "Gene Therapy Emerges From Disgrace to Be the Next Big Thing, Again". Wired – via www.wired.com.
^"University of Pennsylvania Gene Therapy Program | Home". gtp.med.upenn.edu. Retrieved 2018-09-28.
^Gao, Guang-Ping; Alvira, Mauricio R.; Wang, Lili; Calcedo, Roberto; Johnston, Julie; Wilson, James M. (2002-09-03). "Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy". Proceedings of the National Academy of Sciences of the United States of America. 99 (18): 11854–11859. Bibcode:2002PNAS...9911854G. doi:10.1073/pnas.182412299. ISSN 0027-8424. PMC129358. PMID 12192090.
^Gao, Guangping; Vandenberghe, Luk H.; Alvira, Mauricio R.; Lu, You; Calcedo, Roberto; Zhou, Xiangyang; Wilson, James M. (June 2004). "Clades of Adeno-associated viruses are widely disseminated in human tissues". Journal of Virology. 78 (12): 6381–6388. doi:10.1128/JVI.78.12.6381-6388.2004. ISSN 0022-538X. PMC416542. PMID 15163731.
^Yang, Yang; Wang, Lili; Bell, Peter; McMenamin, Deirdre; He, Zhenning; White, John; Yu, Hongwei; Xu, Chenyu; Morizono, Hiroki (March 2016). "A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice". Nature Biotechnology. 34 (3): 334–338. doi:10.1038/nbt.3469. ISSN 1546-1696. PMC4786489. PMID 26829317.
^Wang, Lili; Smith, Jeff; Breton, Camilo; Clark, Peter; Zhang, Jia; Ying, Lei; Che, Yan; Lape, Janel; Bell, Peter (September 2018). "Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol". Nature Biotechnology. 36 (8): 717–725. doi:10.1038/nbt.4182. ISSN 1546-1696. PMID 29985478. S2CID 51600299.
^"University of Pennsylvania Gene Therapy Program | Translational Research Lab". gtp.med.upenn.edu. Retrieved 2018-09-28.
External linksEdit
Gene Therapy Program at the University of Pennsylvania: University of Pennsylvania Gene Therapy Program | Home
Orphan Disease Center at the University of Pennsylvania: Orphan Disease Center | Home
October 21, 2023
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A major contributor to this article appears to have a close connection with its subject It may require cleanup to comply with Wikipedia s content policies particularly neutral point of view Please discuss further on the talk page February 2019 Learn how and when to remove this template message James M Wilson is a biomedical researcher with expertise in gene therapy Wilson graduated from Albion College B A Chemistry and the University of Michigan MD PhD 1 He completed residency training in Internal Medicine at the Massachusetts General Hospital followed by a postdoctoral fellowship at the Whitehead Institute 2 Wilson serves as the Director of the Gene Therapy Program Rose H Weiss Professor and Director of the Orphan Disease Center and Professor of Medicine and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania 3 Previously he held the John Herr Musser endowed professorship at the Perelman School of Medicine 4 Wilson led a clinical trial that resulted in the death of Jesse Gelsinger As a result the government banned him from working on FDA regulated human clinical trials for five years which led to a shift in his research focus towards a study of adeno associated viruses AAV 5 Scientific contributions EditWilson s research involves the development of viral based gene therapies for genetic diseases A major research focus is the generation of novel vectors for improved transduction efficiencies and regulated expression as well as the elucidation of host immune responses to viral vectors 6 His work emphasizes the creation of vectors for in vivo gene therapy concentrating on adeno associated viruses This work began with the discovery in his laboratory of a new family of primate AAVs over 120 new AAV capsids were rescued as latent genomes from primate tissues and studied for their biology and potential as vectors 7 8 This has led to an enhanced understanding of vector host interactions and a new generation of vectors with substantially improved performance profiles beyond that provided from the original 6 AAV isolates More recently Wilson s laboratory has used AAV to accomplish successful in vivo genome editing 9 10 As of 2018 his laboratory s translational research portfolio included more than 30 orphan disease programs 11 References Edit James M Wilson Faculty About Us Perelman School of Medicine Perelman School of Medicine at the University of Pennsylvania www med upenn edu Retrieved 2018 09 28 James M Wilson Faculty Biosketch www med upenn edu Retrieved 2018 09 28 University of Pennsylvania Gene Therapy Program Our Team gtp med upenn edu Retrieved 2018 09 28 John Herr Musser Professorship of Research Medicine Endowed Professorships Perelman School of Medicine at the University of Pennsylvania www med upenn edu Zimmer Carl August 13 2013 Gene Therapy Emerges From Disgrace to Be the Next Big Thing Again Wired via www wired com University of Pennsylvania Gene Therapy Program Home gtp med upenn edu Retrieved 2018 09 28 Gao Guang Ping Alvira Mauricio R Wang Lili Calcedo Roberto Johnston Julie Wilson James M 2002 09 03 Novel adeno associated viruses from rhesus monkeys as vectors for human gene therapy Proceedings of the National Academy of Sciences of the United States of America 99 18 11854 11859 Bibcode 2002PNAS 9911854G doi 10 1073 pnas 182412299 ISSN 0027 8424 PMC 129358 PMID 12192090 Gao Guangping Vandenberghe Luk H Alvira Mauricio R Lu You Calcedo Roberto Zhou Xiangyang Wilson James M June 2004 Clades of Adeno associated viruses are widely disseminated in human tissues Journal of Virology 78 12 6381 6388 doi 10 1128 JVI 78 12 6381 6388 2004 ISSN 0022 538X PMC 416542 PMID 15163731 Yang Yang Wang Lili Bell Peter McMenamin Deirdre He Zhenning White John Yu Hongwei Xu Chenyu Morizono Hiroki March 2016 A dual AAV system enables the Cas9 mediated correction of a metabolic liver disease in newborn mice Nature Biotechnology 34 3 334 338 doi 10 1038 nbt 3469 ISSN 1546 1696 PMC 4786489 PMID 26829317 Wang Lili Smith Jeff Breton Camilo Clark Peter Zhang Jia Ying Lei Che Yan Lape Janel Bell Peter September 2018 Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol Nature Biotechnology 36 8 717 725 doi 10 1038 nbt 4182 ISSN 1546 1696 PMID 29985478 S2CID 51600299 University of Pennsylvania Gene Therapy Program Translational Research Lab gtp med upenn edu Retrieved 2018 09 28 External links EditGene Therapy Program at the University of Pennsylvania University of Pennsylvania Gene Therapy Program HomeOrphan Disease Center at the University of Pennsylvania Orphan Disease Center Home Retrieved from https en wikipedia org w index php title James Wilson scientist amp oldid 1079379620, wikipedia, wiki, book, books, library,
