Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.[1]
^Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R (January 2002). "Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR". Cell. 108 (2): 221–232. doi:10.1016/S0092-8674(02)00616-5. PMID 11832212.
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interferon, gamma, regulatory, element, family, regulatory, rnas, this, family, represents, pseudoknot, containing, stem, loop, structure, found, interferon, gamma, mrna, this, structure, thought, involved, translational, regulation, pseudoknot, been, found, a. Interferon gamma 5 UTR regulatory elements are a family of regulatory RNAs This family represents a pseudoknot containing stem loop structure found in the 5 UTR of interferon gamma mRNA This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R PKR which is known to be a translational inhibitor Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon gamma 1 Interferon gamma 5 UTR regulatory elementPredicted secondary structure and sequence conservation of IFN gammaIdentifiersSymbolIFN gammaRfamRF00259Other dataRNA typeCis regDomain s EukaryotaSOSO 0000204PDB structuresPDBeReferences edit Ben Asouli Y Banai Y Pel Or Y Shir A Kaempfer R January 2002 Human interferon gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon inducible protein kinase PKR Cell 108 2 221 232 doi 10 1016 S0092 8674 02 00616 5 PMID 11832212 External links editPage for Interferon gamma 5 UTR regulatory element at Rfam nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interferon gamma 5 27 UTR regulatory element amp oldid 1032092351, wikipedia, wiki, book, books, library,
