An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in pre-mRNA splicing factors. Interchromatin granules are located in the interchromatin regions of the mammalian Cell nuclei. They usually appear as irregularly shaped structures that vary in size and number. They can be observed by immunofluorescence microscopy.
Interchromatin granules are structures undergoing constant change, and their components exchange continuously with the nucleoplasm, active transcription sites and other nuclear locations.
Research on dynamics of interchromatin granules has provided new insight into the functional organisation of the nucleus and gene expression.
Interchromatin granule clusters vary in size anywhere between one and several micrometers in diameter. They are composed of 20–25 nm granules[1] that are connected in a beaded chain fashion appearance by thin fibrils.
Interchromatin granule clusters (IGCs) have been proposed to be stockpiles of fully mature snRNPs and other RNA processing components that are ready to be used in the production of mRNA.[2]
^Berezney, Ronald; Jeon, Kwang W. (1995). Nuclear Matrix: Structural and Functional Organization. Elsevier. pp. 111–. ISBN9780123846204. Retrieved 1 November 2014.
^Alberts, Bruce. Molecular Biology of the Cell (Fifth ed.). Garland Science. p. 364.
May 18, 2024
interchromatin, granule, interchromatin, granule, cluster, nucleus, mammal, cell, which, enriched, mrna, splicing, factors, located, interchromatin, regions, mammalian, cell, nuclei, they, usually, appear, irregularly, shaped, structures, that, vary, size, num. An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in pre mRNA splicing factors Interchromatin granules are located in the interchromatin regions of the mammalian Cell nuclei They usually appear as irregularly shaped structures that vary in size and number They can be observed by immunofluorescence microscopy Cell biologyComponents of a typical animal cell Nucleolus Nucleus Ribosome dots as part of 5 Vesicle Rough endoplasmic reticulum Golgi apparatus or Golgi body Cytoskeleton Smooth endoplasmic reticulum Mitochondrion Vacuole Cytosol fluid that contains organelles with which comprises cytoplasm Lysosome Centrosome Cell membraneComponents of a typical nucleus 1 Nuclear envelope 1 a Outer membrane 1 b Inner membrane 2 Nucleolus 3 Nucleoplasm 4 Chromatin 4 a Heterochromatin 4 b Euchromatin 5 Ribosome 6 Nuclear pore Interchromatin granules are structures undergoing constant change and their components exchange continuously with the nucleoplasm active transcription sites and other nuclear locations Research on dynamics of interchromatin granules has provided new insight into the functional organisation of the nucleus and gene expression Interchromatin granule clusters vary in size anywhere between one and several micrometers in diameter They are composed of 20 25 nm granules 1 that are connected in a beaded chain fashion appearance by thin fibrils Interchromatin granule clusters IGCs have been proposed to be stockpiles of fully mature snRNPs and other RNA processing components that are ready to be used in the production of mRNA 2 See also editCell nucleus Splicing speckles are subnuclear structures that are enriched in pre messenger RNA splicing factorsReferences edit Berezney Ronald Jeon Kwang W 1995 Nuclear Matrix Structural and Functional Organization Elsevier pp 111 ISBN 9780123846204 Retrieved 1 November 2014 Alberts Bruce Molecular Biology of the Cell Fifth ed Garland Science p 364 Retrieved from https en wikipedia org w index php title Interchromatin granule amp oldid 1176513780, wikipedia, wiki, book, books, library,
