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Infantile hemangiopericytoma

January 01, 1970

Infantile hemangiopericytoma is a cutaneous condition characterized by single or multiple dermal and subcutaneous nodules that may be alarmingly large at birth or grow rapidly.[1][2]

Infantile hemangiopericytoma
Other namesCongenital hemangiopericytoma
Haemangiopericytoma
SpecialtyDermatology

Signs and symptoms edit

Like juvenile hemangiomas, infantile hemangiopericytomas only appear in the subcutis and affect newborns throughout their first year of life. They are characterized by being multilobulated and frequently having separate perivascular and intravascular satellite nodules outside of the main tumor mass.[2] Although there have been reports of numerous lesions,[3][4] the majority of lesions are solitary.[5] The lower extremities, particularly the thigh, pelvic fossa, and retroperitoneum, are where tumors are most frequently found. Less frequently, it affects the upper extremities and trunk. Most are located in muscular tissue and are deep entrenched.[2] There are reports of lesions in the tongue and sublingual area that are present from birth.[6]

Diagnosis edit

Histology must be used to make the diagnosis because the tumor may be hard to differentiate from other neoplasms with similar characteristics.[7] Histologically, hemangiopericytoma is characterized by staghorn-shaped blood vessels and sponge-like sinusoidal vasculature that are randomly linked and encircled by ovoid, short spindle-shaped cells.[8] CD34 positive has a high immunohistochemical correlation with hemangiopericytoma.[9]

Other pediatric tumors such tufted angioma, pyogenic granuloma, infantile hemangioma, kaposiform hemangioendothelioma, and angiosarcoma should be taken into consideration in the differential diagnosis.[8][10]

Treatment edit

Conservative surgery is the best course of action. The preferred method is wide local excision. Chemotherapy is thought to be the next line of treatment for lesions that cannot be removed. When chemotherapy and surgery fail, radiotherapy should be the last resort.[11]

See also edit

References edit

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ a b c SINGH, VP; MUKHOPADHYAY, HG; KANNAN, N; LAKHTAKIA, R; CHOUDHURY, JC; BHOPTE, AG (1995). "Infantile Hemangiopericytoma". Medical Journal Armed Forces India. 51 (2). Elsevier BV: 136–137. doi:10.1016/s0377-1237(17)30948-6. ISSN 0377-1237. PMC 5529909.
  3. ^ Sl, Kauffman (1960). "Hemangiopericytoma in children". Cancer. 13 (4): 695–710. doi:10.1002/1097-0142(196007/08)13:4<695::aid-cncr2820130409>3.0.co;2-9. ISSN 0008-543X. PMID 14404845. Retrieved 2024-05-19.
  4. ^ Seibert, Joanna J.; Seibert, Robert W.; Weisenburger, Dennis S.; Allsbrook, William (1978). "Multiple congenital hemangiopericytomas of the head and neck". The Laryngoscope. 88 (6). Wiley: 1006–1012. doi:10.1288/00005537-197806000-00012. ISSN 0023-852X. PMID 651500.
  5. ^ Enzinger, Franz M.; Smith, Bruce H. (1976). "Hemangiopericytoma". Human Pathology. 7 (1). Elsevier BV: 61–82. doi:10.1016/s0046-8177(76)80006-8. ISSN 0046-8177. PMID 1244311.
  6. ^ Alpers, Charles E.; Rosenau, Werner; Finkbeiner, Walter E.; De Lorimier, Alfred A.; Kronish, Daniel (1984-03-01). "Congenital (Infantile) Hemangiopericytoma of the Tongue and Sublingual Region". American Journal of Clinical Pathology. 81 (3). Oxford University Press (OUP): 377–382. doi:10.1093/ajcp/81.3.377. ISSN 1943-7722. PMID 6702731.
  7. ^ Michael, Kim; Eikmeier, April; Mueller, Virginia (2010). "Infantile Hemangiopericytoma". Journal of Diagnostic Medical Sonography. 26 (4): 198–201. doi:10.1177/8756479310374359. ISSN 8756-4793.
  8. ^ a b Boynuyogun, Etkin; Calis, Mert; Kavuncuoglu, Altan; Kosemehmetoglu, Kemal; Tuncbilek, Gokhan (2021-09-03). "Presentation of Infantile Hemangiopericytoma/Solitary Fibrous Tumor as a Giant Extracranial Temporal Mass". Fetal and Pediatric Pathology. 40 (5): 523–527. doi:10.1080/15513815.2020.1716904. ISSN 1551-3815.
  9. ^ Espat, N. Joseph; Lewis, Jonathan J.; Leung, Denis; Woodruff, James M.; Antonescu, Christina R.; Shia, Jingu; Brennan, Murray F. (2002-10-03). "Conventional hemangiopericytoma". Cancer. 95 (8). Wiley: 1746–1751. doi:10.1002/cncr.10867. ISSN 0008-543X. PMID 12365023.
  10. ^ Sulit, Daryl J.; Tom, Wynnis L.; Willert, Jennifer R.; Nespeca, Mark P.; Friedlander, Sheila Fallon (2011). "Multicentric Infantile Hemangiopericytoma". Journal of Pediatric Hematology/Oncology. 33 (4). Ovid Technologies (Wolters Kluwer Health): e166–e170. doi:10.1097/mph.0b013e3182145627. ISSN 1077-4114. PMID 21516017.
  11. ^ Virden, Charles P.; Lynch, Frank P. (1993). "Infantile hemangiopericytoma: A rare cause of a soft tissue mass". Journal of Pediatric Surgery. 28 (5). Elsevier BV: 741–743. doi:10.1016/0022-3468(93)90047-o. ISSN 0022-3468. PMID 8340873.

Further reading edit

  • Pérez, Alba; Vigil, Sara; Pescador, Isabel; Fernández, Beatriz; Jiménez, Lidia; Agra, Carolina; de Rojas, Teresa; Sánchez-Luna, Manuel (2018-01-04). "Infantile hemangiopericytoma leading to hypovolemic shock in a neonate". Pediatric Blood & Cancer. 65 (5). Wiley. doi:10.1002/pbc.26950. ISSN 1545-5009. PMID 29314578.
  • Futagami, A.; Aoki, M.; Iwakiri, I.; Hyakusoku, H.; Kawamoto, M.; Kawana, S. (2006). "Infantile Hemangiopericytoma – Case Report and Literature Review". Pediatric Dermatology. 23 (4): 335–337. doi:10.1111/j.1525-1470.2006.00263.x. ISSN 0736-8046. PMID 16918627.

External links edit

  • National Cancer Institute

January 01, 1970
infantile, hemangiopericytoma, cutaneous, condition, characterized, single, multiple, dermal, subcutaneous, nodules, that, alarmingly, large, birth, grow, rapidly, other, namescongenital, hemangiopericytomahaemangiopericytomaspecialtydermatology, contents, sig. Infantile hemangiopericytoma is a cutaneous condition characterized by single or multiple dermal and subcutaneous nodules that may be alarmingly large at birth or grow rapidly 1 2 Infantile hemangiopericytomaOther namesCongenital hemangiopericytomaHaemangiopericytomaSpecialtyDermatology Contents 1 Signs and symptoms 2 Diagnosis 3 Treatment 4 See also 5 References 6 Further reading 7 External linksSigns and symptoms editLike juvenile hemangiomas infantile hemangiopericytomas only appear in the subcutis and affect newborns throughout their first year of life They are characterized by being multilobulated and frequently having separate perivascular and intravascular satellite nodules outside of the main tumor mass 2 Although there have been reports of numerous lesions 3 4 the majority of lesions are solitary 5 The lower extremities particularly the thigh pelvic fossa and retroperitoneum are where tumors are most frequently found Less frequently it affects the upper extremities and trunk Most are located in muscular tissue and are deep entrenched 2 There are reports of lesions in the tongue and sublingual area that are present from birth 6 Diagnosis editHistology must be used to make the diagnosis because the tumor may be hard to differentiate from other neoplasms with similar characteristics 7 Histologically hemangiopericytoma is characterized by staghorn shaped blood vessels and sponge like sinusoidal vasculature that are randomly linked and encircled by ovoid short spindle shaped cells 8 CD34 positive has a high immunohistochemical correlation with hemangiopericytoma 9 Other pediatric tumors such tufted angioma pyogenic granuloma infantile hemangioma kaposiform hemangioendothelioma and angiosarcoma should be taken into consideration in the differential diagnosis 8 10 Treatment editConservative surgery is the best course of action The preferred method is wide local excision Chemotherapy is thought to be the next line of treatment for lesions that cannot be removed When chemotherapy and surgery fail radiotherapy should be the last resort 11 See also editHemangiopericytoma List of cutaneous conditionsReferences edit Rapini Ronald P Bolognia Jean L Jorizzo Joseph L 2007 Dermatology 2 Volume Set St Louis Mosby ISBN 978 1 4160 2999 1 a b c SINGH VP MUKHOPADHYAY HG KANNAN N LAKHTAKIA R CHOUDHURY JC BHOPTE AG 1995 Infantile Hemangiopericytoma Medical Journal Armed Forces India 51 2 Elsevier BV 136 137 doi 10 1016 s0377 1237 17 30948 6 ISSN 0377 1237 PMC 5529909 Sl Kauffman 1960 Hemangiopericytoma in children Cancer 13 4 695 710 doi 10 1002 1097 0142 196007 08 13 4 lt 695 aid cncr2820130409 gt 3 0 co 2 9 ISSN 0008 543X PMID 14404845 Retrieved 2024 05 19 Seibert Joanna J Seibert Robert W Weisenburger Dennis S Allsbrook William 1978 Multiple congenital hemangiopericytomas of the head and neck The Laryngoscope 88 6 Wiley 1006 1012 doi 10 1288 00005537 197806000 00012 ISSN 0023 852X PMID 651500 Enzinger Franz M Smith Bruce H 1976 Hemangiopericytoma Human Pathology 7 1 Elsevier BV 61 82 doi 10 1016 s0046 8177 76 80006 8 ISSN 0046 8177 PMID 1244311 Alpers Charles E Rosenau Werner Finkbeiner Walter E De Lorimier Alfred A Kronish Daniel 1984 03 01 Congenital Infantile Hemangiopericytoma of the Tongue and Sublingual Region American Journal of Clinical Pathology 81 3 Oxford University Press OUP 377 382 doi 10 1093 ajcp 81 3 377 ISSN 1943 7722 PMID 6702731 Michael Kim Eikmeier April Mueller Virginia 2010 Infantile Hemangiopericytoma Journal of Diagnostic Medical Sonography 26 4 198 201 doi 10 1177 8756479310374359 ISSN 8756 4793 a b Boynuyogun Etkin Calis Mert Kavuncuoglu Altan Kosemehmetoglu Kemal Tuncbilek Gokhan 2021 09 03 Presentation of Infantile Hemangiopericytoma Solitary Fibrous Tumor as a Giant Extracranial Temporal Mass Fetal and Pediatric Pathology 40 5 523 527 doi 10 1080 15513815 2020 1716904 ISSN 1551 3815 Espat N Joseph Lewis Jonathan J Leung Denis Woodruff James M Antonescu Christina R Shia Jingu Brennan Murray F 2002 10 03 Conventional hemangiopericytoma Cancer 95 8 Wiley 1746 1751 doi 10 1002 cncr 10867 ISSN 0008 543X PMID 12365023 Sulit Daryl J Tom Wynnis L Willert Jennifer R Nespeca Mark P Friedlander Sheila Fallon 2011 Multicentric Infantile Hemangiopericytoma Journal of Pediatric Hematology Oncology 33 4 Ovid Technologies Wolters Kluwer Health e166 e170 doi 10 1097 mph 0b013e3182145627 ISSN 1077 4114 PMID 21516017 Virden Charles P Lynch Frank P 1993 Infantile hemangiopericytoma A rare cause of a soft tissue mass Journal of Pediatric Surgery 28 5 Elsevier BV 741 743 doi 10 1016 0022 3468 93 90047 o ISSN 0022 3468 PMID 8340873 Further reading editPerez Alba Vigil Sara Pescador Isabel Fernandez Beatriz Jimenez Lidia Agra Carolina de Rojas Teresa Sanchez Luna Manuel 2018 01 04 Infantile hemangiopericytoma leading to hypovolemic shock in a neonate Pediatric Blood amp Cancer 65 5 Wiley doi 10 1002 pbc 26950 ISSN 1545 5009 PMID 29314578 Futagami A Aoki M Iwakiri I Hyakusoku H Kawamoto M Kawana S 2006 Infantile Hemangiopericytoma Case Report and Literature Review Pediatric Dermatology 23 4 335 337 doi 10 1111 j 1525 1470 2006 00263 x ISSN 0736 8046 PMID 16918627 External links editNational Cancer Institute Retrieved from https en wikipedia org w index php title Infantile hemangiopericytoma amp oldid 1224567172, wikipedia, wiki, book, books, library,

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