Iberogast, also known as STW5, is a liquid formulation of nine herbs used for functional dyspepsia and irritable bowel syndrome. A proprietary blend, it was developed in Germany in 1961 and is available (without prescription) in other countries. Named after the genus (Iberis) of one of its ingredients, it is also claimed to possess anti-inflammatory, antioxidative and free radical-inhibiting properties as well as the ability to reduce gastric acid secretion.[1]
A 2004 meta-analysis comprising three randomized placebo-controlled studies with a total of 173 patients suggested that iberogast was more effective than placebo in relieving "the most bothersome gastrointestinal symptom" of functional dyspepsia as identified by each patient. Additionally, a single reference-controlled study was discussed, comparing iberogast to the prokinetic cisapride in the treatment of "'functional dyspepsia of the dysmotility type'" and finding no significant differences in efficacy or tolerability. This paper noted that, while iberogast seems to consistently provide symptomatic relief to patients, its efficacy is more evident "with associated symptoms of gastro-oesophageal reflux or predominance of epigastric pain." It suggests a synergy of therapeutic mechanisms provided by the complex interactions between the GI tract and each individual component of iberogast. It also supports a promising safety profile for the formulation, but notes that its results must be confirmed in larger studies in order to provide any recommendations regarding the efficacy or safety of iberogast in the treatment of functional dyspepsia.[3]
SafetyEdit
In Germany, Iberogast has come under investigation after one patient died of liver failure. In 2018, the company producing Iberogast (Bayer) has been forced by authorities to print warnings about rare cases of liver toxicity. A former employee of Bayer was under criminal investigation related to Bayer's long resistance to declare the dangers of Iberogast.[4]
ReferencesEdit
^Wegener T, Wagner H (2006). "The active components and the pharmacological multi-target principle of STW 5 (Iberogast)". Phytomedicine. 13 (Suppl 5): 20–35. doi:10.1016/j.phymed.2006.07.001. PMID 16926095.
^Saller R, Pfister-Hotz G, Iten F, Melzer J, Reichling J (2002). "[Iberogast: a modern phytotherapeutic combined herbal drug for the treatment of functional disorders of the gastrointestinal tract (dyspepsia, irritable bowel syndrome)--from phytomedicine to "evidence based phytotherapy". A systematic review]". Forschende Komplementärmedizin und Klassische Naturheilkunde (in German). 9 (Suppl 1): 1–20. doi:10.1159/000068645. PMID 12618546. S2CID 59214884.
^Melzer J, Rösch W, Reichling J, Brignoli R, Saller R (2004). "Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast)". Alimentary Pharmacology and Therapeutics. 20 (11–12): 1279–87. doi:10.1111/j.1365-2036.2004.02275.x. PMID 15606389.
iberogast, also, known, stw5, liquid, formulation, nine, herbs, used, functional, dyspepsia, irritable, bowel, syndrome, proprietary, blend, developed, germany, 1961, available, without, prescription, other, countries, named, after, genus, iberis, ingredients,. Iberogast also known as STW5 is a liquid formulation of nine herbs used for functional dyspepsia and irritable bowel syndrome A proprietary blend it was developed in Germany in 1961 and is available without prescription in other countries Named after the genus Iberis of one of its ingredients it is also claimed to possess anti inflammatory antioxidative and free radical inhibiting properties as well as the ability to reduce gastric acid secretion 1 Iberogast is a mixture of extracts from bitter candytuft Iberis amara angelica root Angelicae radix milk thistle fruit Silybi mariani fructus celandine herb Chelidonium majus caraway fruit Carvi fructus liquorice root Liquiritiae radix peppermint herb Menthae piperitae folium balm leaf Melissae folium and chamomile flower Matricariae flos 2 Contents 1 Medical uses 2 Safety 3 References 4 External linksMedical uses EditA 2004 meta analysis comprising three randomized placebo controlled studies with a total of 173 patients suggested that iberogast was more effective than placebo in relieving the most bothersome gastrointestinal symptom of functional dyspepsia as identified by each patient Additionally a single reference controlled study was discussed comparing iberogast to the prokinetic cisapride in the treatment of functional dyspepsia of the dysmotility type and finding no significant differences in efficacy or tolerability This paper noted that while iberogast seems to consistently provide symptomatic relief to patients its efficacy is more evident with associated symptoms of gastro oesophageal reflux or predominance of epigastric pain It suggests a synergy of therapeutic mechanisms provided by the complex interactions between the GI tract and each individual component of iberogast It also supports a promising safety profile for the formulation but notes that its results must be confirmed in larger studies in order to provide any recommendations regarding the efficacy or safety of iberogast in the treatment of functional dyspepsia 3 Safety EditIn Germany Iberogast has come under investigation after one patient died of liver failure In 2018 the company producing Iberogast Bayer has been forced by authorities to print warnings about rare cases of liver toxicity A former employee of Bayer was under criminal investigation related to Bayer s long resistance to declare the dangers of Iberogast 4 References Edit Wegener T Wagner H 2006 The active components and the pharmacological multi target principle of STW 5 Iberogast Phytomedicine 13 Suppl 5 20 35 doi 10 1016 j phymed 2006 07 001 PMID 16926095 Saller R Pfister Hotz G Iten F Melzer J Reichling J 2002 Iberogast a modern phytotherapeutic combined herbal drug for the treatment of functional disorders of the gastrointestinal tract dyspepsia irritable bowel syndrome from phytomedicine to evidence based phytotherapy A systematic review Forschende Komplementarmedizin und Klassische Naturheilkunde in German 9 Suppl 1 1 20 doi 10 1159 000068645 PMID 12618546 S2CID 59214884 Melzer J Rosch W Reichling J Brignoli R Saller R 2004 Meta analysis phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 Iberogast Alimentary Pharmacology and Therapeutics 20 11 12 1279 87 doi 10 1111 j 1365 2036 2004 02275 x PMID 15606389 Nebenwirkungen von Iberogast Archive External links EditIberogast at the U S National Library of Medicine Medical Subject Headings MeSH Retrieved from https en wikipedia org w index php title Iberogast amp oldid 1171071927, wikipedia, wiki, book, books, library,
