Immunoglobulin kappa locus, also known as IGK@, is a region on the p arm of human chromosome 2, region 11.2 (2p11.2), that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).[2]
In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.[3] These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.
Genesedit
The immunoglobulin kappa locus contains the following genes:
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Criscitiello MF, Flajnik MF (2007). "Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates". Eur. J. Immunol. 37 (10): 2683–94. doi:10.1002/eji.200737263. PMC7094790. PMID 17899545.
^Male, D., Brostoff, J., Roth, D.B., & Roitt, I. 2006. Immunology. 7th ed., Canada: Elsevier Limited
Further readingedit
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immunoglobulin, kappa, locus, also, known, region, human, chromosome, region, 2p11, that, contains, genes, kappa, light, chains, antibodies, immunoglobulins, igkidentifiersaliasesigk, immunoglobulin, kappa, locusexternal, idsgenecards, igkorthologsspecieshuman. Immunoglobulin kappa locus also known as IGK is a region on the p arm of human chromosome 2 region 11 2 2p11 2 that contains genes for the kappa k light chains of antibodies or immunoglobulins 2 IGKIdentifiersAliasesIGK IGK immunoglobulin kappa locusExternal IDsGeneCards IGKOrthologsSpeciesHumanMouseEntrez50802n aEnsembln an aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC n an aPubMed search 1 n aWikidataView Edit Human In humans the k chain is coded for by V variable J joining and C constant genes in this region 3 These genes undergo V D J recombination to generate a diverse repertoire of immunoglobulins Genes editThe immunoglobulin kappa locus contains the following genes IGKC immunoglobulin kappa constant IGKJ immunoglobulin kappa joining group IGKJ1 IGKJ2 IGKJ3 IGKJ4 IGKJ5 IGKV immunoglobulin kappa variable group IGKV1 5 IGKV1 6 IGKV1 8 IGKV1 9 IGKV1 12 IGKV1 16 IGKV1 17 IGKV1 27 IGKV1 33 IGKV1D 8 IGKV1D 12 IGKV1D 13 IGKV1D 16 IGKV1D 17 IGKV1D 22 IGKV1D 27 IGKV1D 32 IGKV1D 33 IGKV1D 39 IGKV1D 43 IGKV2 24 IGKV2 28 IGKV2 30 IGKV2 40 IGKV2D 26 IGKV2D 28 IGKV2D 29 IGKV2D 30 IGKV2D 40 IGKV3 11 IGKV3 15 IGKV3 20 IGKV3D 7 IGKV3D 11 IGKV3D 20 IGKV4 1 IGKV5 2 and a number of non functional and pseudogenesReferences edit Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Criscitiello MF Flajnik MF 2007 Four primordial immunoglobulin light chain isotypes including lambda and kappa identified in the most primitive living jawed vertebrates Eur J Immunol 37 10 2683 94 doi 10 1002 eji 200737263 PMC 7094790 PMID 17899545 Male D Brostoff J Roth D B amp Roitt I 2006 Immunology 7th ed Canada Elsevier LimitedFurther reading edit nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IGK amp oldid 1114484527, wikipedia, wiki, book, books, library,
