This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000099869 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yang JM, Chen WS, Liu ZP, Luo YH, Liu WW (March 2003). "Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells". J. Gastroenterol. Hepatol. 18 (3): 296–301. doi:10.1046/j.1440-1746.2003.02961.x. PMID 12603530. S2CID 24390333.
Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM (May 2007). "IGF-II gene region polymorphisms related to exertional muscle damage". J. Appl. Physiol. 102 (5): 1815–23. CiteSeerX10.1.1.329.715. doi:10.1152/japplphysiol.01165.2006. PMID 17289909. S2CID 2136915.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q (October 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC2722857. PMID 18676680.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q (May 2009). "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China". Environ. Mol. Mutagen. 50 (4): 285–90. Bibcode:2009EnvMM..50..285S. doi:10.1002/em.20452. PMC2666781. PMID 19170196.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q (December 2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respir Med. 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC2783799. PMID 19625176.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N (February 2010). "Genetic susceptibility to distinct bladder cancer subphenotypes". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC3220186. PMID 19692168.
Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, Easton DF (October 2009). "Identification of seven new prostate cancer susceptibility loci through a genome-wide association study". Nat. Genet. 41 (10): 1116–21. doi:10.1038/ng.450. PMC2846760. PMID 19767753.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC2775832. PMID 19913121.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC2810344. PMID 19948975.
igf2, igf2, antisense, protein, that, humans, encoded, gene, identifiersaliases, peg8, igf2, antisense, rnaexternal, idsomim, 610146, genecards, gene, location, human, chromosome, human, band11p15, 5start2, end2, expression, patternbgeehumanmouse, ortholog, ex. IGF2 antisense RNA is a protein that in humans is encoded by the IGF2 AS gene 3 IGF2 ASIdentifiersAliasesIGF2 AS IGF2 AS1 PEG8 IGF2 antisense RNAExternal IDsOMIM 610146 GeneCards IGF2 ASGene location Human Chr Chromosome 11 human 1 Band11p15 5Start2 140 501 bp 1 End2 148 666 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentaright lobe of liverstromal cell of endometriumislet of Langerhansfacetibial nerveganglionic eminenceleft uterine tubemouthmyometriumn aMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez51214n aEnsemblENSG00000099869n aUniProtnan aRefSeq mRNA NM 016412n aRefSeq protein n an aLocation UCSC Chr 11 2 14 2 15 Mbn aPubMed search 2 n aWikidataView Edit HumanFunction editThis gene is expressed in antisense to the insulin like growth factor 2 IGF2 gene and is imprinted and paternally expressed It is thought to be non coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay NMD Transcripts from this gene are produced in tumors and may function to suppress cell growth Alternative splicing results in multiple transcript variants provided by RefSeq Nov 2015 References edit a b c GRCh38 Ensembl release 89 ENSG00000099869 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene IGF2 antisense RNA Retrieved 2018 03 07 Further reading editYang JM Chen WS Liu ZP Luo YH Liu WW March 2003 Effects of insulin like growth factors IR and IIR antisense gene transfection on the biological behaviors of SMMC 7721 human hepatoma cells J Gastroenterol Hepatol 18 3 296 301 doi 10 1046 j 1440 1746 2003 02961 x PMID 12603530 S2CID 24390333 Devaney JM Hoffman EP Gordish Dressman H Kearns A Zambraski E Clarkson PM May 2007 IGF II gene region polymorphisms related to exertional muscle damage J Appl Physiol 102 5 1815 23 CiteSeerX 10 1 1 329 715 doi 10 1152 japplphysiol 01165 2006 PMID 17289909 S2CID 2136915 Hosgood HD Menashe I Shen M Yeager M Yuenger J Rajaraman P He X Chatterjee N Caporaso NE Zhu Y Chanock SJ Zheng T Lan Q October 2008 Pathway based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway Carcinogenesis 29 10 1938 43 doi 10 1093 carcin bgn178 PMC 2722857 PMID 18676680 Shen M Vermeulen R Rajaraman P Menashe I He X Chapman RS Yeager M Thomas G Burdett L Hutchinson A Yuenger J Chanock S Lan Q May 2009 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei China Environ Mol Mutagen 50 4 285 90 Bibcode 2009EnvMM 50 285S doi 10 1002 em 20452 PMC 2666781 PMID 19170196 Hosgood HD Menashe I He X Chanock S Lan Q December 2009 PTEN identified as important risk factor of chronic obstructive pulmonary disease Respir Med 103 12 1866 70 doi 10 1016 j rmed 2009 06 016 PMC 2783799 PMID 19625176 Guey LT Garcia Closas M Murta Nascimento C Lloreta J Palencia L Kogevinas M Rothman N Vellalta G Calle ML Marenne G Tardon A Carrato A Garcia Closas R Serra C Silverman DT Chanock S Real FX Malats N February 2010 Genetic susceptibility to distinct bladder cancer subphenotypes Eur Urol 57 2 283 92 doi 10 1016 j eururo 2009 08 001 PMC 3220186 PMID 19692168 Eeles RA Kote Jarai Z Al Olama AA Giles GG Guy M Severi G Muir K Hopper JL Henderson BE Haiman CA Schleutker J Hamdy FC Neal DE Donovan JL Stanford JL Ostrander EA Ingles SA John EM Thibodeau SN Schaid D Park JY Spurdle A Clements J Dickinson JL Maier C Vogel W Dork T Rebbeck TR Cooney KA Cannon Albright L Chappuis PO Hutter P Zeegers M Kaneva R Zhang HW Lu YJ Foulkes WD English DR Leongamornlert DA Tymrakiewicz M Morrison J Ardern Jones AT Hall AL O Brien LT Wilkinson RA Saunders EJ Page EC Sawyer EJ Edwards SM Dearnaley DP Horwich A Huddart RA Khoo VS Parker CC Van As N Woodhouse CJ Thompson A Christmas T Ogden C Cooper CS Southey MC Lophatananon A Liu JF Kolonel LN Le Marchand L Wahlfors T Tammela TL Auvinen A Lewis SJ Cox A FitzGerald LM Koopmeiners JS Karyadi DM Kwon EM Stern MC Corral R Joshi AD Shahabi A McDonnell SK Sellers TA Pow Sang J Chambers S Aitken J Gardiner RA Batra J Kedda MA Lose F Polanowski A Patterson B Serth J Meyer A Luedeke M Stefflova K Ray AM Lange EM Farnham J Khan H Slavov C Mitkova A Cao G Easton DF October 2009 Identification of seven new prostate cancer susceptibility loci through a genome wide association study Nat Genet 41 10 1116 21 doi 10 1038 ng 450 PMC 2846760 PMID 19767753 Talmud PJ Drenos F Shah S Shah T Palmen J Verzilli C Gaunt TR Pallas J Lovering R Li K Casas JP Sofat R Kumari M Rodriguez S Johnson T Newhouse SJ Dominiczak A Samani NJ Caulfield M Sever P Stanton A Shields DC Padmanabhan S Melander O Hastie C Delles C Ebrahim S Marmot MG Smith GD Lawlor DA Munroe PB Day IN Kivimaki M Whittaker J Humphries SE Hingorani AD November 2009 Gene centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Am J Hum Genet 85 5 628 42 doi 10 1016 j ajhg 2009 10 014 PMC 2775832 PMID 19913121 McGeachie M Ramoni RL Mychaleckyj JC Furie KL Dreyfuss JM Liu Y Herrington D Guo X Lima JA Post W Rotter JI Rich S Sale M Ramoni MF December 2009 Integrative predictive model of coronary artery calcification in atherosclerosis Circulation 120 24 2448 54 doi 10 1161 CIRCULATIONAHA 109 865501 PMC 2810344 PMID 19948975 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IGF2 AS amp oldid 1216913123, wikipedia, wiki, book, books, library,
