Hydrophilization is a process used for hydrophobic drugs to increase their release rate from capsules, which is dependent on the rate of dissolution, by covering the surface of the drug particles with minute droplets of a hydrophilic polymer solution.[1]
Methodedit
The process is accomplished by vigorous mixing of the hydrophobic drug with the aqueous solution of the hydrophilic polymer solution, leading to production of small particles of the drug covered with small droplets of the hydrophilic polymer solution.[1]
Usesedit
This process in tablet or capsule formulations enhance the disintegration of the drug/excipient bulk and so enhance the rate of dissolution of the hydrophobic drug.[1]
^ abcLerk CF, Lagas M, Fell JT, Nauta P (July 1978). "Effect of hydrophilization of hydrophobic drugs on release rate from capsules". Journal of Pharmaceutical Sciences. 67 (7): 935–9. doi:10.1002/jps.2600670716. PMID 660511.
^Panraksa, Pattaraporn; Udomsom, Suruk; Rachtanapun, Pornchai; Chittasupho, Chuda; Ruksiriwanich, Warintorn; Jantrawut, Pensak (November 2020). "Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer". Polymers. 12 (11): 2666. doi:10.3390/polym12112666. ISSN 2073-4360. PMC7696250. PMID 33198094.
January 01, 1970
hydrophilization, this, article, multiple, issues, please, help, improve, discuss, these, issues, talk, page, learn, when, remove, these, template, messages, topic, this, article, meet, wikipedia, general, notability, guideline, please, help, demonstrate, nota. This article has multiple issues Please help improve it or discuss these issues on the talk page Learn how and when to remove these template messages The topic of this article may not meet Wikipedia s general notability guideline Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention If notability cannot be shown the article is likely to be merged redirected or deleted Find sources Hydrophilization news newspapers books scholar JSTOR August 2022 Learn how and when to remove this message This article relies excessively on references to primary sources Please improve this article by adding secondary or tertiary sources Find sources Hydrophilization news newspapers books scholar JSTOR August 2022 Learn how and when to remove this message Learn how and when to remove this message Hydrophilization is a process used for hydrophobic drugs to increase their release rate from capsules which is dependent on the rate of dissolution by covering the surface of the drug particles with minute droplets of a hydrophilic polymer solution 1 Method editThe process is accomplished by vigorous mixing of the hydrophobic drug with the aqueous solution of the hydrophilic polymer solution leading to production of small particles of the drug covered with small droplets of the hydrophilic polymer solution 1 Uses editThis process in tablet or capsule formulations enhance the disintegration of the drug excipient bulk and so enhance the rate of dissolution of the hydrophobic drug 1 Examples of the hydrophilic polymers are methyl cellulose and hydroxyethyl cellulose 2 References edit a b c Lerk CF Lagas M Fell JT Nauta P July 1978 Effect of hydrophilization of hydrophobic drugs on release rate from capsules Journal of Pharmaceutical Sciences 67 7 935 9 doi 10 1002 jps 2600670716 PMID 660511 Panraksa Pattaraporn Udomsom Suruk Rachtanapun Pornchai Chittasupho Chuda Ruksiriwanich Warintorn Jantrawut Pensak November 2020 Hydroxypropyl Methylcellulose E15 A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer Polymers 12 11 2666 doi 10 3390 polym12112666 ISSN 2073 4360 PMC 7696250 PMID 33198094 Retrieved from https en wikipedia org w index php title Hydrophilization amp oldid 1205942574, wikipedia, wiki, book, books, library,
