He was awarded the Nobel Prize in Medicine in 1943 for joint work with Edward Doisy in discovering vitamin K and its role in humanphysiology. Dam's key experiment involved feeding a cholesterol-free diet to chickens.[1] He initially replicated experiments reported by scientists at the Ontario Agricultural College (OAC).[2] McFarlane, Graham and Richardson, working on the chick feed program at OAC, had used chloroform to remove all fat from chick chow. They noticed that chicks fed only fat-depleted chow developed hemorrhages and started bleeding from tag sites.[3] Dam found that these defects could not be restored by adding purified cholesterol to the diet. It appeared that—together with the cholesterol—a second compound had been extracted from the food, and this compound was called the coagulation vitamin. The new vitamin received the letter K because the initial discoveries were reported in a German journal, in which it was designated as Koagulationsvitamin.
He received an undergraduate degree in chemistry from the Copenhagen Polytechnic Institute (now the Technical University of Denmark) in 1920, and was appointed as assistant instructor in chemistry at the School of Agriculture and Veterinary Medicine. By 1923 he had attained the post of instructor in biochemistry at Copenhagen University's Physiological Laboratory. He studied microchemistry at the University of Graz under Fritz Pregl in 1925, but returned to Copenhagen University, where he was appointed as an assistant professor at the Institute of Biochemistry in 1928, and assistant professor in 1929. During his time as professor at Copenhagen University he spent some time working abroad, and in 1934 submitted a thesis entitled Nogle Undersøgelser over Sterinernes Biologiske Betydning (Some investigations on the biological significance of the sterines) to Copenhagen University, and received the degree of Ph.D. in biochemistry.
Between 1942 and 1945 Dam was a senior research associate at the University of Rochester; it was during this period that he was awarded the 1943 Nobel Prize for Physiology or Medicine. In 1951, he was one of seven Nobel Laureates who attended the first Lindau Nobel Laureate Meeting.[4]
^Dam H (1935). "The Antihæmorrhagic Vitamin of the Chick.: Occurrence And Chemical Nature". Nature. 135 (3417): 652–653. Bibcode:1935Natur.135..652D. doi:10.1038/135652b0. S2CID 4104430.
^Dam H (1943). "The discovery of vitamin K, its biological functions and therapeutical application" (PDF). Nobel Prize Laureate Lecture.
^McAlister V (2006). (PDF). Clin Invest Med. 29 (6): 373–377. PMID 17330453. Archived from the original (PDF) on 6 March 2010.
^"1st Lindau Nobel Laureate Meeting - Laureates". www.mediatheque.lindau-nobel.org. Retrieved 9 January 2018.
External links
Wikimedia Commons has media related to Henrik Carl Peter Dam.
Henrik Dam on Nobelprize.org including the Nobel Lecture on December 12, 1946 The Discovery of Vitamin K, Its Biological Functions and Therapeutical Application
January 20, 2023
henrik, danish, transport, minister, kristensen, carl, peter, danish, carl, peter, february, 1895, april, 1976, danish, biochemist, physiologist, born, 1895, february, 1895copenhagen, denmarkdied17, april, 1976, 1976, aged, copenhagen, denmarkeducationcopenhag. For the Danish transport minister see Henrik Dam Kristensen Carl Peter Henrik Dam Danish Carl Peter Henrik Dam 21 February 1895 17 April 1976 was a Danish biochemist and physiologist Henrik DamBorn 1895 02 21 21 February 1895Copenhagen DenmarkDied17 April 1976 1976 04 17 aged 81 Copenhagen DenmarkEducationCopenhagen Polytechnic Institute now the Technical University of Denmark University of GrazKnown forDiscovery of vitamin KScientific careerFieldsBiochemistry and physiologyInstitutionsUniversity of Copenhagen University of RochesterThesisNogle Undersogelser over Sterinernes Biologiske Betydning Some investigations on the biological significance of the sterines 1934 InfluencesFritz PreglDam with his wife in Stockholm in 1946 He was awarded the Nobel Prize in Medicine in 1943 for joint work with Edward Doisy in discovering vitamin K and its role in human physiology Dam s key experiment involved feeding a cholesterol free diet to chickens 1 He initially replicated experiments reported by scientists at the Ontario Agricultural College OAC 2 McFarlane Graham and Richardson working on the chick feed program at OAC had used chloroform to remove all fat from chick chow They noticed that chicks fed only fat depleted chow developed hemorrhages and started bleeding from tag sites 3 Dam found that these defects could not be restored by adding purified cholesterol to the diet It appeared that together with the cholesterol a second compound had been extracted from the food and this compound was called the coagulation vitamin The new vitamin received the letter K because the initial discoveries were reported in a German journal in which it was designated as Koagulationsvitamin He received an undergraduate degree in chemistry from the Copenhagen Polytechnic Institute now the Technical University of Denmark in 1920 and was appointed as assistant instructor in chemistry at the School of Agriculture and Veterinary Medicine By 1923 he had attained the post of instructor in biochemistry at Copenhagen University s Physiological Laboratory He studied microchemistry at the University of Graz under Fritz Pregl in 1925 but returned to Copenhagen University where he was appointed as an assistant professor at the Institute of Biochemistry in 1928 and assistant professor in 1929 During his time as professor at Copenhagen University he spent some time working abroad and in 1934 submitted a thesis entitled Nogle Undersogelser over Sterinernes Biologiske Betydning Some investigations on the biological significance of the sterines to Copenhagen University and received the degree of Ph D in biochemistry Between 1942 and 1945 Dam was a senior research associate at the University of Rochester it was during this period that he was awarded the 1943 Nobel Prize for Physiology or Medicine In 1951 he was one of seven Nobel Laureates who attended the first Lindau Nobel Laureate Meeting 4 See also EditUniversity of Rochester List of Nobel Laureates affiliated with the University of RochesterReferences Edit Dam H 1935 The Antihaemorrhagic Vitamin of the Chick Occurrence And Chemical Nature Nature 135 3417 652 653 Bibcode 1935Natur 135 652D doi 10 1038 135652b0 S2CID 4104430 Dam H 1943 The discovery of vitamin K its biological functions and therapeutical application PDF Nobel Prize Laureate Lecture McAlister V 2006 Control of coagulation a gift of Canadian agriculture PDF Clin Invest Med 29 6 373 377 PMID 17330453 Archived from the original PDF on 6 March 2010 1st Lindau Nobel Laureate Meeting Laureates www mediatheque lindau nobel org Retrieved 9 January 2018 External links Edit Wikimedia Commons has media related to Henrik Carl Peter Dam Henrik Dam on Nobelprize org including the Nobel Lecture on December 12 1946 The Discovery of Vitamin K Its Biological Functions and Therapeutical Application Retrieved from https en wikipedia org w index php title Henrik Dam amp oldid 1095286573, wikipedia, wiki, book, books, library,
