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Hemorphin

March 20, 2024

Hemorphins are a class of naturally occurring, endogenous opioid peptides which are found in the bloodstream, and are derived from the β-chain of hemoglobin.[1][2] They have antinociceptive effects via activation of the opioid receptors,[2][3] and some may also play a role in blood pressure through inhibition of the angiotensin-converting enzyme (ACE),[4] as well as cause an elevation of endogenous enkephalin levels.[5] Some examples of hemorphins include hemorphin-4, spinorphin, and valorphin.

See also edit

References edit

  1. ^ Brantl V, Gramsch C, Lottspeich F, Mertz R, Jaeger KH, Herz A (June 1986). "Novel opioid peptides derived from hemoglobin: hemorphins". European Journal of Pharmacology. 125 (2): 309–10. doi:10.1016/0014-2999(86)90044-0. PMID 3743640.
  2. ^ a b Davis TP, Gillespie TJ, Porreca F (1989). "Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo". Peptides. 10 (4): 747–51. doi:10.1016/0196-9781(89)90107-1. PMID 2587417. S2CID 11168006.
  3. ^ Liebmann C, Schrader U, Brantl V (August 1989). "Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin". European Journal of Pharmacology. 166 (3): 523–6. doi:10.1016/0014-2999(89)90368-3. PMID 2553436.
  4. ^ Lantz I, Glämsta EL, Talbäck L, Nyberg F (August 1991). "Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity". FEBS Letters. 287 (1–2): 39–41. doi:10.1016/0014-5793(91)80011-Q. PMID 1652464.
  5. ^ Benuck M, Berg MJ, Marks N (1982). "Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes". Neurochemistry International. 4 (5): 389–96. doi:10.1016/0197-0186(82)90081-X. PMID 20487892. S2CID 23138078.

March 20, 2024
hemorphin, class, naturally, occurring, endogenous, opioid, peptides, which, found, bloodstream, derived, from, chain, hemoglobin, they, have, antinociceptive, effects, activation, opioid, receptors, some, also, play, role, blood, pressure, through, inhibition. Hemorphins are a class of naturally occurring endogenous opioid peptides which are found in the bloodstream and are derived from the b chain of hemoglobin 1 2 They have antinociceptive effects via activation of the opioid receptors 2 3 and some may also play a role in blood pressure through inhibition of the angiotensin converting enzyme ACE 4 as well as cause an elevation of endogenous enkephalin levels 5 Some examples of hemorphins include hemorphin 4 spinorphin and valorphin See also editCasomorphinReferences edit Brantl V Gramsch C Lottspeich F Mertz R Jaeger KH Herz A June 1986 Novel opioid peptides derived from hemoglobin hemorphins European Journal of Pharmacology 125 2 309 10 doi 10 1016 0014 2999 86 90044 0 PMID 3743640 a b Davis TP Gillespie TJ Porreca F 1989 Peptide fragments derived from the beta chain of hemoglobin hemorphins are centrally active in vivo Peptides 10 4 747 51 doi 10 1016 0196 9781 89 90107 1 PMID 2587417 S2CID 11168006 Liebmann C Schrader U Brantl V August 1989 Opioid receptor affinities of the blood derived tetrapeptides hemorphin and cytochrophin European Journal of Pharmacology 166 3 523 6 doi 10 1016 0014 2999 89 90368 3 PMID 2553436 Lantz I Glamsta EL Talback L Nyberg F August 1991 Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity FEBS Letters 287 1 2 39 41 doi 10 1016 0014 5793 91 80011 Q PMID 1652464 Benuck M Berg MJ Marks N 1982 Separate metabolic pathways for Leu enkephalin and Met enkephalin Arg 6 Phe 7 degradation by rat striatal synaptosomal membranes Neurochemistry International 4 5 389 96 doi 10 1016 0197 0186 82 90081 X PMID 20487892 S2CID 23138078 Retrieved from https en wikipedia org w index php title Hemorphin amp oldid 1194311456, wikipedia, wiki, book, books, library,

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