HLA-DR2 (DR2) of the HLA-DRserotype system, is a broad antigenserotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
^Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
^van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.
^Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 (Suppl 1): 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
^Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.
^Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.
^Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.
April 08, 2024
serotype, system, broad, antigen, serotype, that, preferentially, covered, dr15, dr16, serotype, group, this, serotype, primarily, recognizes, gene, products, drb1, drb1, allele, groups, illustration, contents, serology, disease, associations, genetic, linkage. HLA DR2 DR2 of the HLA DR serotype system is a broad antigen serotype that is now preferentially covered by HLA DR15 and HLA DR16 serotype group This serotype primarily recognizes gene products of the HLA DRB1 15 and HLA DRB1 16 allele groups Illustration of HLA DR Contents 1 Serology 2 Disease associations 3 Genetic linkage 4 ReferencesSerology editDR15 DR2 and other serotype recognition of some DRB1 15 alleles 1 DRB1 DR15 DR2 DR16 Sampleallele size N 15 01 76 23 642815 02 77 16 67615 03 81 13 28615 04 gt 50 115 05 gt 25 215 07 gt 50 1 DR16 DR2 DR15 N16 01 41 29 19 70316 02 47 30 16 23916 04 gt 50 1Disease associations editDR2 serotypes are associated with Goodpasture syndrome systemic lupus erythematosus multiple sclerosis 2 narcolepsy tuberculoid leprosy 3 multi drug resistant tuberculosis or leprosy 4 ulcerative colitis Japanese 5 primary biliary cirrhosis and autoimmune hepatitis 6 DR2 is also found in all patients that test positive for anti Asn RNA synthetase and chronic interstitial lung disease 7 Genetic linkage editDR2 is linked to the HLA DR51 References edit derived from IMGT HLA Stewart G McLeod J Basten A Bashir H 1981 HLA family studies and multiple sclerosis A common gene dominantly expressed Hum Immunol 3 1 13 29 doi 10 1016 0198 8859 81 90040 9 PMID 7275697 van Eden W de Vries R Mehra N Vaidya M D Amaro J van Rood J 1980 HLA segregation of tuberculoid leprosy confirmation of the DR2 marker J Infect Dis 141 6 693 701 doi 10 1093 infdis 141 6 693 PMID 6156220 Singh M Balamurugan A Katoch K Sharma SK Mehra NK 2007 Immunogenetics of mycobacterial infections in the North Indian population Tissue Antigens 69 Suppl 1 228 30 doi 10 1111 j 1399 0039 2006 77311 x PMID 17445206 Asakura H Tsuchiya M Aiso S Watanabe M Kobayashi K Hibi T Ando K Takata H Sekiguchi S 1982 Association of the human lymphocyte DR2 antigen with Japanese ulcerative colitis Gastroenterology 82 3 413 8 doi 10 1016 S0016 5085 82 80387 9 PMID 6947923 Miyamori H Kato Y Kobayashi K Hattori N 1983 HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis Digestion 26 4 213 7 doi 10 1159 000198892 PMID 6409699 Hirakata M Suwa A Takada T et al 2007 Clinical and immunogenetic features of patients with autoantibodies to asparaginyl transfer RNA synthetase Arthritis Rheum 56 4 1295 303 doi 10 1002 art 22506 PMID 17393393 Retrieved from https en wikipedia org w index php title HLA DR2 amp oldid 1217016000, wikipedia, wiki, book, books, library,
