HLA-B15 (B15) is an HLA-Bserotype. The serotype identifies the B*15 gene-allele protein products of HLA-B.[1]
B15 is a broad antigen and can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B*15 is the largest allele grouping for any known human autosomal locus, identified as of August 2008 there are more than 150 alleles and ~140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. Other alleles, such as B*46 evolved from B*15. One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia. As people traveled east the frequency of many alleles dropped or disappeared from migrants. However B*15 persisted, expanded and diversified.[2] The wide range and complex environment selected for new alleles and promoted their expansion. B*46 for example is not found in Africa, and appears to have evolved and spread in East Asia, to several 100 million bearers worldwide.
^Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; et al. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC2848993. PMID 20356336.
^Hildebrand WH, Domena JD, Shen SY, et al. (April 1994). "HLA-B15: a widespread and diverse family of HLA-B alleles". Tissue Antigens. 43 (4): 209–18. doi:10.1111/j.1399-0039.1994.tb02327.x. PMID 7521976.
^ Augusto, D.G.; Murdolo, L.G.; Chatzileontiadou, D.S.M.; et al. (July 2023). "A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection". Nature. doi:10.1038/s41586-023-06331-x. PMC10396966.
also, history, naming, human, leukocyte, antigens, alpha, β2mg, with, bound, peptidemajor, histocompatibility, complex, human, class, b15alleles, structure, shared, datalocus, 6p21, serotype, serotype, identifies, gene, allele, protein, products, broad, antige. See also History and naming of human leukocyte antigens HLA B 15 01 alpha b2MG with bound peptidemajor histocompatibility complex human class I B15Alleles B 15 01 15 02 Structure See HLA B Shared dataLocus chr 6 6p21 31HLA B15 B15 is an HLA B serotype The serotype identifies the B 15 gene allele protein products of HLA B 1 B15 is a broad antigen and can be subdivided into several split antigens that are often used in characterization These are B62 B63 B70 B71 B72 B75 B76 B77 B 15 is the largest allele grouping for any known human autosomal locus identified as of August 2008 there are more than 150 alleles and 140 amino acid sequence variants from those gene products Some of these alleles are discussed below Other alleles such as B 46 evolved from B 15 One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia As people traveled east the frequency of many alleles dropped or disappeared from migrants However B 15 persisted expanded and diversified 2 The wide range and complex environment selected for new alleles and promoted their expansion B 46 for example is not found in Africa and appears to have evolved and spread in East Asia to several 100 million bearers worldwide HLA B15 allele 15 02 is associated with the severe skin conditions Stevens Johnson syndrome SJS and toxic epidermal necrolysis TEN caused by carbamazepine drug sensitivity in East Asians Carriers of the HLA B15 allele 15 01 B62 are much more likely to be asymptomatic when infected with SARS CoV 2 the virus that causes COVID 19 3 Serotype editSerotypes B15 B62 B63 B70 B71 B72 B75 B76 B77 recognition of the HLA B 15 gene products 4 B 15 B15 B62 B63 B70 B71 B72 B75 B76 B77 Sample Desig allele size N nation 15 01 2 96 1906 B62 15 02 7 22 62 1035 B75 15 03 1 61 10 2569 B70 15 04 10 69 29 B62 15 05 18 64 22 B62 15 06 40 20 11 10 B62 15 07 79 101 B62 15 08 20 18 45 B62 15 09 53 65 B70 15 10 1 49 2 2 1 1204 B70 15 11 15 27 21 68 B62 15 12 17 18 8 12 B62 15 13 15 8 19 12 21 116 B77 15 15 13 49 28 138 B62 15 16 3 80 816 B63 15 17 2 88 797 B63 15 18 51 3 552 B70 15 20 100 5 B62 15 21 7 12 55 132 B75 15 24 44 54 B62 15 25 7 74 8 116 B62 15 27 7 76 76 B62 15 28 14 57 14 7 B62 15 29 19 21 B70 15 30 17 64 98 B62 15 31 50 12 B62 15 35 79 34 B62 15 37 30 34 B70Allele B15 B62 B63 B70 B71 B72 B75 B76 B77 NAlleles link out to IPD IMGT HLA Database at EBIReferences edit Marsh S G Albert E D Bodmer W F et al 2010 Nomenclature for factors of the HLA system 2010 Tissue Antigens 75 4 291 455 doi 10 1111 j 1399 0039 2010 01466 x PMC 2848993 PMID 20356336 Hildebrand WH Domena JD Shen SY et al April 1994 HLA B15 a widespread and diverse family of HLA B alleles Tissue Antigens 43 4 209 18 doi 10 1111 j 1399 0039 1994 tb02327 x PMID 7521976 Augusto D G Murdolo L G Chatzileontiadou D S M et al July 2023 A common allele of HLA is associated with asymptomatic SARS CoV 2 infection Nature doi 10 1038 s41586 023 06331 x PMC 10396966 derived from IMGT HLA Retrieved from https en wikipedia org w index php title HLA B15 amp oldid 1193821031 Serotype, wikipedia, wiki, book, books, library,
